Targeting the MGBA with -biotics in epilepsy: New insights from preclinical and clinical studies
Antonella Riva,Elisa Pozzati,Mattia Grasso,Carmen De Caro,Emilio Russo,Alberto Verrotti,Pasquale Striano +6 more
TLDR
In this paper , a review aims to give an overview of the possible beneficial effects of the supplementation of -biotics in epilepsy treatment, including prebiotics, probiotics, symbiotic (a fair combination of both), and diet.About:
This article is published in Neurobiology of Disease.The article was published on 2022-05-16 and is currently open access. It has received 4 citations till now. The article focuses on the topics: Medicine & Epilepsy.read more
Citations
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Editorial: The gut microbiome and epilepsy
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Let Food be thy medicine. The Interaction between Ketogenic Diet Therapy and Antiseizure Medications: A systematic review.
Marisa Armeno,Eric H. Kossoff +1 more
TL;DR: In this article , the authors discuss the evidence for possible negative (or positive) pharmacodynamic interactions between ketogenic dietary therapy (KDT) and antiseizure medications (ASMs), and provide practical suggestions for the weaning or adding of ASMs in patients on KDT.
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Poo Matters! A scoping review of the impact of constipation on epilepsy
Alexandra Gabrielsson,Samuel Tromans,Lance Watkins,Lisa Burrows,Richard Laugharne,Rohit Shankar +5 more
TL;DR: A scoping review registered on PROSPERO (CRD42022320079) with suitable search terms was conducted and reported in accordance with PRISMA guidance as discussed by the authors .
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The microbiome-gut-brain axis in Epilepsy: Pharmacotherapeutic target from bench evidence for potential bedside applications.
S Kundu,Sudipta Nayak,Debarati Rakshit,Tanveer Singh,Rahul Shukla,Dharmendra Kumar Khatri,Awanish Mishra +6 more
TL;DR: In this paper , the authors investigated the connection between the Gut Microbiota and Epilepsy and found that the level of Proteobacteria, Verrucomicrobia, Fusobacteria and Firmicutes increased in the epilepsy patients.
References
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A human gut microbial gene catalogue established by metagenomic sequencing
Junjie Qin,Ruiqiang Li,Jeroen Raes,Manimozhiyan Arumugam,Kristoffer Sølvsten Burgdorf,Chaysavanh Manichanh,Trine Nielsen,Nicolas Pons,Florence Levenez,Takuji Yamada,Daniel R. Mende,Junhua Li,Junming Xu,Shaochuan Li,Dongfang Li,Jianjun Cao,Bo Wang,Huiqing Liang,Huisong Zheng,Yinlong Xie,Julien Tap,Patricia Lepage,Marcelo Bertalan,Jean-Michel Batto,Torben Hansen,Denis Le Paslier,Allan Linneberg,H. Bjørn Nielsen,Eric Pelletier,Pierre Renault,Thomas Sicheritz-Pontén,Keith Turner,Hongmei Zhu,Chang Yu,Shengting Li,Min Jian,Yan Zhou,Yingrui Li,Xiuqing Zhang,Songgang Li,Nan Qin,Huanming Yang,Jian Wang,Søren Brunak,Joël Doré,Francisco Guarner,Karsten Kristiansen,Oluf Pedersen,Julian Parkhill,Jean Weissenbach,Peer Bork,S. Dusko Ehrlich,Jun Wang +52 more
TL;DR: The Illumina-based metagenomic sequencing, assembly and characterization of 3.3 million non-redundant microbial genes, derived from 576.7 gigabases of sequence, from faecal samples of 124 European individuals are described, indicating that the entire cohort harbours between 1,000 and 1,150 prevalent bacterial species and each individual at least 160 such species.
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Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic
Colin Hill,Francisco Guarner,Gregor Reid,Glenn R. Gibson,Daniel Merenstein,Bruno Pot,Lorenzo Morelli,Roberto Berni Canani,Harry J. Flint,Seppo Salminen,Philip C. Calder,Mary Ellen Sanders +11 more
TL;DR: An expert panel was convened in October 2013 by the International Scientific Association for Probiotics and Prebiotics (ISAPP) to discuss the field of probiotics and the appropriate use and scope of the term probiotic.
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The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis
Patrick M. Smith,Michael R. Howitt,Nicolai Panikov,Monia Michaud,Carey Ann Gallini,Mohammad Bohlooly-Y,Jonathan N. Glickman,Wendy S. Garrett +7 more
TL;DR: This study determined that short-chain fatty acids, gut microbiota–derived bacterial fermentation products, regulate the size and function of the colonic Treg pool and protect against colitis in a Ffar2-dependent manner in mice, revealing that a class of abundant microbial metabolites underlies adaptive immune microbiota coadaptation and promotes colonic homeostasis and health.
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Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
Yukihiro Furusawa,Yuuki Obata,Shinji Fukuda,Takaho A. Endo,Gaku Nakato,Daisuke Takahashi,Yumiko Nakanishi,Chikako Uetake,Keiko Kato,Tamotsu Kato,Masumi Takahashi,Noriko N. Fukuda,Shinnosuke Murakami,Eiji Miyauchi,Shingo Hino,Koji Atarashi,Satoshi Onawa,Yumiko Fujimura,Trevor Lockett,Julie M. Clarke,David L. Topping,Masaru Tomita,Shohei Hori,Osamu Ohara,Tatsuya Morita,Haruhiko Koseki,Jun Kikuchi,Kenya Honda,Koji Hase,Hiroshi Ohno +29 more
TL;DR: It is shown that a large bowel microbial fermentation product, butyrate, induces the differentiation of colonic Treg cells in mice and ameliorated the development of colitis induced by adoptive transfer of CD4+ CD45RBhi T cells in Rag1−/− mice.
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Richness of human gut microbiome correlates with metabolic markers
Trine Nielsen,Junjie Qin,Edi Prifti,Falk Hildebrand,Gwen Falony,Mathieu Almeida,Manimozhiyan Arumugam,Jean-Michel Batto,Sean Kennedy,Pierre Leonard,Junhua Li,Kristoffer Sølvsten Burgdorf,Niels Grarup,Torben Jørgensen,Torben Jørgensen,Torben Jørgensen,Ivan Brandslund,Henrik Nielsen,Agnieszka S. Juncker,Marcelo Bertalan,Florence Levenez,Nicolas Pons,Simon Rasmussen,Shinichi Sunagawa,Julien Tap,Sebastian Tims,Erwin G. Zoetendal,Søren Brunak,Karine Clément,Karine Clément,Joël Doré,Michiel Kleerebezem,Karsten Kristiansen,Pierre Renault,Thomas Sicheritz-Pontén,Willem M. de Vos,Willem M. de Vos,Jean-Daniel Zucker,Jean-Daniel Zucker,Jean-Daniel Zucker,Jeroen Raes,Torben Hansen,Torben Hansen,Peer Bork,Jun Wang,S. Dusko Ehrlich,Oluf Pedersen +46 more
TL;DR: The authors' classifications based on variation in the gut microbiome identify subsets of individuals in the general white adult population who may be at increased risk of progressing to adiposity-associated co-morbidities.