The BAFF/APRIL system: Emerging functions beyond B cell biology and autoimmunity
Fabien B. Vincent,Damien Saulep-Easton,William A. Figgett,Kirsten A. Fairfax,Fabienne Mackay +4 more
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TLDR
The latest views on additional roles of the BAFF system in health and diseases are provided, as well as an update on BAFF and autoimmunity, with particular focus on current clinical trials.About:
This article is published in Cytokine & Growth Factor Reviews.The article was published on 2013-06-01 and is currently open access. It has received 317 citations till now. The article focuses on the topics: BAFF receptor & B-cell activating factor.read more
Citations
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The BAFF/APRIL system in SLE pathogenesis
TL;DR: Results suggesting that neutralizing BAFF can have effects on the immune system other than depletion of B cells are reviewed, and aspects of the BAFF system for which data in relation to SLE are still missing are identified.
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B Cells, Antibodies, and More
TL;DR: The multifaceted roles of B cells as enhancers and regulators of immunity with relevance to kidney disease and transplantation are discussed.
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γ-secretase directly sheds the survival receptor BCMA from plasma cells
Sarah Laurent,Franziska Hoffmann,Peer-Hendrik Kuhn,Qingyu Cheng,Yuanyuan Chu,Marc Schmidt-Supprian,Stefanie M. Hauck,Elisabeth Schuh,Markus Krumbholz,Heike Rübsamen,Johanna Wanngren,Mohsen Khademi,Tomas Olsson,Tobias Alexander,Falk Hiepe,Hans-Walter Pfister,Frank Weber,Dieter E. Jenne,Hartmut Wekerle,Reinhard Hohlfeld,Stefan F. Lichtenthaler,Edgar Meinl +21 more
TL;DR: Together, shedding of BCMA by γ-secretase controls plasma cells in the bone marrow and yields a potential biomarker for B-cell involvement in human autoimmune diseases.
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The TNF Family of Ligands and Receptors: Communication Modules in the Immune System and Beyond
TL;DR: There remains a need to better understand the fundamental mechanisms underlying the molecular pathways they mediate to design more effective anti-inflammatory and anti-cancer therapies.
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Cytokine networking of innate immunity cells: a potential target of therapy.
TL;DR: The innate immune system down-regulates effector mechanisms and restores homoeostasis in injured tissue via cytokines from the IL-10 and TGF (transforming growth factor) families mainly released from macrophages, preferentially the M2 subset, which have a capacity to induce regulatory T-cells.
References
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Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial
Sandra V. Navarra,Renato Guzman,Alberto E. Gallacher,Stephen B. Hall,Roger A. Levy,Renato E. Jimenez,Edmund K. Li,Mathew Thomas,Ho-Youn Kim,Manuel G. León,Coman Tanasescu,Eugeny L. Nasonov,Joung-Liang Lan,Lilia Pineda,Z. John Zhong,William W. Freimuth,Michelle A. Petri +16 more
TL;DR: The efficacy and safety of the fully human monoclonal antibody belimumab (BLyS-specific inhibitor) was assessed in patients with active systemic lupus erythematosus in a multicentre phase 3 study done in Latin America, Asia-Pacific, and eastern Europe.
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Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations.
Fabienne Mackay,Stephen A. Woodcock,Pornsri Lawton,Christine Ambrose,Manfred Baetscher,Pascal Schneider,Jürg Tschopp,Jeffrey L. Browning +7 more
TL;DR: Mice transgenic for BAFF have vastly increased numbers of mature B and effector T cells, and develop autoimmune-like manifestations such as the presence of high levels of rheumatoid factors, circulating immune complexes, anti–DNA autoantibodies, and immunoglobulin deposition in the kidneys.
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BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth.
Pascal Schneider,Fabienne Mackay,Véronique Steiner,Kay Hofmann,Jean Luc Bodmer,Nils Holler,Christine Ambrose,Pornsri Lawton,Sarah A. Bixler,Hans Acha-Orbea,Danila Valmori,Pedro Romero,Christiane Werner-Favre,Rudolph H. Zubler,Jeffrey L. Browning,Jürg Tschopp +15 more
TL;DR: A novel member of the T NF family, designated BAFF (for B cell activating factor belonging to the TNF family), which is expressed by T cells and dendritic cells is described, suggesting that BAFF plays an important role as costimulator of B cell proliferation and function.
Journal ArticleDOI
TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease
Jane A. Gross,Janet V. Johnston,Sherri Mudri,Rachel Enselman,Stacey R. Dillon,Karen L. Madden,Wenfeng Xu,Julia Parrish-Novak,Don Foster,Catherine Lofton-Day,Margaret D. Moore,Alisa Littau,Angelika Grossman,Harald S. Haugen,Kevin P. Foley,Hal Blumberg,Kim Harrison,Wayne R. Kindsvogel,Christopher H. Clegg +18 more
TL;DR: These findings demonstrate the involvement of zTNF4 and its receptors in the development of SLE and identify TACI–Ig as a promising treatment of autoimmune disease in humans.
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A phase III, randomized, placebo-controlled study of belimumab, a monoclonal antibody that inhibits B lymphocyte stimulator, in patients with systemic lupus erythematosus
Richard Furie,Michelle A. Petri,Omid Zamani,Ricard Cervera,Daniel J. Wallace,D. Tegzova,Jorge Sanchez-Guerrero,Andreas Schwarting,Joan T. Merrill,W. Winn Chatham,William Stohl,Ellen M. Ginzler,Douglas R. Hough,Z. John Zhong,William W. Freimuth,Ronald F van Vollenhoven +15 more
TL;DR: Belimumab plus standard therapy significantly improved SRI response rate, reduced SLE disease activity and severe flares, and was generally well tolerated in SLE.