Journal ArticleDOI
The caffeoylquinic acid-rich Pandanus tectorius fruit extract increases insulin sensitivity and regulates hepatic glucose and lipid metabolism in diabetic db/db mice
Chongming Wu,Xiaopo Zhang,Xue Zhang,Hong Luan,Guibo Sun,Xiaobo Sun,Xiaoliang Wang,Peng Guo,Xudong Xu +8 more
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TLDR
Overall, the CQA-rich PTF is beneficial for the treatment of diabetes and may alleviate hyperglycemia and dyslipidemia via activation of AMPK-AS160-GLUT4 pathway in skeletal muscles and inhibition of gluconeogenesis and lipogenesis in the liver.Abstract:
Caffeoylquinic acids (CQAs) are widely distributed in various foods. While some CQAs have been shown to possess antihyperglycemic activities, whether it is beneficial for diabetes patients to ingest CQA-rich foods has still to be known. In this work, the antihyperglycemic and antihyperlipidemic effects of CQA-rich Pandanus tectorius fruit extract (PTF) was investigated in diabetic db/db mice. Treatment with PTF (200 mg/kg) significantly decreased body weight and fasting glucose level, alleviated hyperinsulinism and hyperlipidemia and declined glucose area under the curve in oral glucose tolerance test and insulin tolerance test. The elevated levels of serum proinflammatory cytokines and islet hypertrophy in db/db mice were remarkably attenuated by PTF treatment. Biochemical analysis showed that administration of PTF significantly stimulated the phosphorylation of AMP-activated protein kinase (AMPK) and Akt substract of 160 kDa (AS160), and enhanced the expression and translocation of glucose transporter type 4 (GLUT4) in skeletal muscles. It also increased the activity of hexokinase, decreased the expression of glucose 6-phosphatase and phosphoenolpyruvate carboxykinase and switched the transcription of several key lipid metabolic genes in the liver, which, in turn, improved hepatic glucose and lipid profiles as determined by nuclear magnetic resonance-based metabolomics. Overall, the CQA-rich PTF is beneficial for the treatment of diabetes. It may alleviate hyperglycemia and dyslipidemia via activation of AMPK-AS160-GLUT4 pathway in skeletal muscles and inhibition of gluconeogenesis and lipogenesis in the liver.read more
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Phytochemical analysis, antioxidant, antibacterial and cytotoxicity properties of keys and cores part of Pandanus tectorius fruits
Yosie Andriani,Yosie Andriani,Nadiah Madihah Ramli,Desy Fitrya Syamsumir,Murni Nur Islamiah Kassim,Jasmin Jaafar,Nur Asniza Aziz,Leni Marlina,Noor Suryani Musa,Habsah Mohamad +9 more
TL;DR: In this paper, the authors determined the phytochemical content, antibacterial and antioxidant activities, total phenolic content (TPC) and cytotoxicity properties of Pandanus tectorius fruits extracts against some normal (RAW and L-6) and cancer cell lines (HeLa, HepG2 and MCF-7).
Journal ArticleDOI
Embracing nutritional qualities, biological activities and technological properties of coffee byproducts in functional food formulation
TL;DR: In this article, the authors present up-to-date information with reference to compositional data, potential of incorporating coffee byproducts as ingredients in food formulations and new product development with respect to their biological functionality and technological importance.
Journal ArticleDOI
Chrysin inhibits foam cell formation through promoting cholesterol efflux from RAW264.7 macrophages
TL;DR: Chrysin is a new inhibitor of foam cell formation that may stimulate cholesterol flow and up-regulation of the classical PPARγ–LXRα–ABCA1/ ABCG1/ABCG1 pathway and down- regulation of SR-A1 andSR-A2 may participate in its suppressive effect on intracellular cholesterol accumulation.
Journal ArticleDOI
Asperlin Inhibits LPS-Evoked Foam Cell Formation and Prevents Atherosclerosis in ApoE-/- Mice.
TL;DR: It is suggested that asperlin is adequate to prevent atherosclerosis in vivo and may exert atheroprotective function through suppressing inflammation rather than ameliorating dyslipidemia.
Journal ArticleDOI
Morus nigra leaf extract improves glycemic response and redox profile in the liver of diabetic rats
Carolina Morais Araujo,Karine de Pádua Lúcio,Marcelo Eustáquio Silva,Mauro César Isoldi,Gustavo Henrique Bianco de Souza,Geraldo Célio Brandão,Richard Schulz,Daniela Caldeira Costa +7 more
TL;DR: It is demonstrated that treatment of diabetic rats with leaf extracts decreased the superoxide dismutase (SOD)/catalase (CAT) ratio and carbonylated protein levels by reducing oxidative stress, suggesting the utility of this herbal remedy in the prevention and treatment of DM.
References
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