The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials
Julian P T Higgins,Douglas G. Altman,Peter C Gøtzsche,Peter Jüni,David Moher,Andrew D Oxman,Jelena Savović,Kenneth F. Schulz,Laura Weeks,Jonathan A C Sterne +9 more
TLDR
The Cochrane Collaboration’s tool for assessing risk of bias aims to make the process clearer and more accurate.Abstract:
Flaws in the design, conduct, analysis, and reporting of randomised trials can cause the effect of an intervention to be underestimated or overestimated. The Cochrane Collaboration’s tool for assessing risk of bias aims to make the process clearer and more accurateread more
Citations
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Journal ArticleDOI
Selenium for preventing cancer
Gabriele Dennert,Marcel Zwahlen,Maree Brinkman,Marco Vinceti,Maurice P. Zeegers,Markus Horneber +5 more
TL;DR: Despite evidence for an inverse association between selenium exposure and the risk of some types of cancer, these results should be interpreted with care due to the potential limiting factors of heterogeneity and influences of unknown biases, confounding and effect modification.
Journal ArticleDOI
Viscoelastic point-of-care testing to assist with the diagnosis, management and monitoring of haemostasis: a systematic review and cost-effectiveness analysis.
Penny Whiting,Maiwenn Al,Marie Westwood,Isaac Corro Ramos,Steve Ryder,Nigel Armstrong,Kate Misso,Janine Ross,Johan L. Severens,Jos Kleijnen +9 more
TL;DR: This assessment aimed to assess the clinical effectiveness and cost-effectiveness of VE devices to assist with the diagnosis, management and monitoring of haemostasis disorders during and after cardiac surgery, trauma-induced coagulopathy and post-partum haemorrhage.
Journal ArticleDOI
The Effectiveness of Platelet-Rich Plasma in the Treatment of Tendinopathy A Meta-analysis of Randomized Controlled Clinical Trials
TL;DR: There is good evidence to support the use of a single injection of LR-PRP under ultrasound guidance in tendinopathy, and both the preparation and intratendinous injection technique of PRP appear to be of great clinical significance.
Journal ArticleDOI
Percutaneous coronary interventional strategies for treatment of in-stent restenosis: a network meta-analysis
George C.M. Siontis,George C.M. Siontis,Giulio G. Stefanini,Dimitris Mavridis,Konstantinos C. Siontis,Fernando Alfonso,María José Pérez-Vizcayno,Robert A. Byrne,Adnan Kastrati,Bernhard Meier,Georgia Salanti,Peter Jüni,Stephan Windecker +12 more
TL;DR: These findings suggest that two strategies should be considered for treatment of any type of coronary ISR: PCI with everolimus-eluting stents because of the best angiographic and clinical outcomes, and DCB because of its ability to provide favourable results without adding a new stent layer.
Journal ArticleDOI
Pharmacotherapy for the prevention of chronic pain after surgery in adults
TL;DR: Meta-analysis suggested a modest but statistically significant reduction in the incidence of chronic pain after surgery following treatment with ketamine but not gabapentin or pregabalin, and available evidence does not support the efficacy of gabAPentin, pregABalin, non-steroidal anti-inflammatories, intravenous steroids, oral NMDA blockers or inhaled nitrous oxide for the prevention of chronic postoperative pain.
References
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Book
Cochrane Handbook for Systematic Reviews of Interventions
Julian P T Higgins,Sally Green +1 more
TL;DR: The Cochrane Handbook for Systematic Reviews of Interventions is the official document that describes in detail the process of preparing and maintaining Cochrane systematic reviews on the effects of healthcare interventions.
Journal Article
Cochrane Handbook for Systematic Reviews of Interventions
Journal ArticleDOI
GRADE: an emerging consensus on rating quality of evidence and strength of recommendations
Gordon H. Guyatt,Andrew D Oxman,Gunn Elisabeth Vist,Regina Kunz,Yngve Falck-Ytter,Pablo Alonso-Coello,Holger J. Schünemann +6 more
TL;DR: The advantages of the GRADE system are explored, which is increasingly being adopted by organisations worldwide and which is often praised for its high level of consistency.
Book ChapterDOI
Assessing Risk of Bias in Included Studies
TL;DR: In this paper, the authors propose a new algorithm called 1.8.1.1-2.0-1.8-1/2.8/1/1.
Journal ArticleDOI
Systematic reviews in health care: Assessing the quality of controlled clinical trials
TL;DR: The concept of study quality and the methods used to assess quality are discussed and the methodology for both the assessment of quality and its incorporation into systematic reviews and meta-analysis is discussed.