The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials
Julian P T Higgins,Douglas G. Altman,Peter C Gøtzsche,Peter Jüni,David Moher,Andrew D Oxman,Jelena Savović,Kenneth F. Schulz,Laura Weeks,Jonathan A C Sterne +9 more
TLDR
The Cochrane Collaboration’s tool for assessing risk of bias aims to make the process clearer and more accurate.Abstract:
Flaws in the design, conduct, analysis, and reporting of randomised trials can cause the effect of an intervention to be underestimated or overestimated. The Cochrane Collaboration’s tool for assessing risk of bias aims to make the process clearer and more accurateread more
Citations
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Journal ArticleDOI
Efficacy of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
TL;DR: These RCTs provide scientific evidence that supports the efficacy of turmeric extract (about 1000 mg/day of curcumin) in the treatment of arthritis, but more rigorous and larger studies are needed to confirm the therapeutic efficacy of Turmeric for arthritis.
Journal ArticleDOI
Effects of weight loss interventions for adults who are obese on mortality, cardiovascular disease, and cancer: systematic review and meta-analysis.
Chenhan Ma,Alison Avenell,Mark J Bolland,Jemma Hudson,Fiona Stewart,Clare Robertson,Pawana Sharma,Cynthia Fraser,Graeme MacLennan +8 more
TL;DR: Weight reducing diets, usually low in fat and saturated fat, with or without exercise advice or programmes, for adults with obesity and follow-up ≥1 year may reduce premature all cause mortality in adults with Obesity.
Journal ArticleDOI
Efficacy of PD-1 or PD-L1 inhibitors and PD-L1 expression status in cancer: meta-analysis.
Xian Shen,Bin Zhao +1 more
TL;DR: It is suggested that PD-L1 expression status alone is insufficient in determining which patients should be offered PD-1 or PD- L1 blockade therapy, which is a preferable treatment option over conventional therapy for both patients that are PD- l1 positive and PD-l1 negative.
Journal ArticleDOI
Influence of initial severity of depression on effectiveness of low intensity interventions: meta-analysis of individual patient data
Peter Bower,Evangelos Kontopantelis,Alex J. Sutton,Tony Kendrick,David Richards,Simon Gilbody,Sarah Knowles,Pim Cuijpers,Gerhard Andersson,Helen Christensen,Björn Meyer,Marcus J.H. Huibers,Filip Smit,Annemieke van Straten,Lisanne Warmerdam,Michael Barkham,Linda L. Bilich,Karina Lovell,Emily T. Liu +18 more
TL;DR: The data suggest that patients with more severe depression at baseline show at least as much clinical benefit from low intensity interventions as less severely depressed patients and could usefully be offered these interventions as part of a stepped care model.
Journal ArticleDOI
European Stroke Organisation (ESO) – European Society for Minimally Invasive Neurological Therapy (ESMINT) Guidelines on Mechanical Thrombectomy in Acute Ischaemic StrokeEndorsed by Stroke Alliance for Europe (SAFE):
Guillaume Turc,Pervinder Bhogal,Urs Fischer,Pooja Khatri,Kyriakos Lobotesis,Mikael Mazighi,Peter D. Schellinger,Danilo Toni,Joost de Vries,Philip White,Jens Fiehler +10 more
TL;DR: High quality evidence to recommend MT plus best medical management (BMM, including intravenous thrombolysis whenever indicated) to improve functional outcome in patients with LVO-related acute ischaemic stroke within 6 hours after symptom onset is found.
References
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Book
Cochrane Handbook for Systematic Reviews of Interventions
Julian P T Higgins,Sally Green +1 more
TL;DR: The Cochrane Handbook for Systematic Reviews of Interventions is the official document that describes in detail the process of preparing and maintaining Cochrane systematic reviews on the effects of healthcare interventions.
Journal Article
Cochrane Handbook for Systematic Reviews of Interventions
Journal ArticleDOI
GRADE: an emerging consensus on rating quality of evidence and strength of recommendations
Gordon H. Guyatt,Andrew D Oxman,Gunn Elisabeth Vist,Regina Kunz,Yngve Falck-Ytter,Pablo Alonso-Coello,Holger J. Schünemann +6 more
TL;DR: The advantages of the GRADE system are explored, which is increasingly being adopted by organisations worldwide and which is often praised for its high level of consistency.
Book ChapterDOI
Assessing Risk of Bias in Included Studies
TL;DR: In this paper, the authors propose a new algorithm called 1.8.1.1-2.0-1.8-1/2.8/1/1.
Journal ArticleDOI
Systematic reviews in health care: Assessing the quality of controlled clinical trials
TL;DR: The concept of study quality and the methods used to assess quality are discussed and the methodology for both the assessment of quality and its incorporation into systematic reviews and meta-analysis is discussed.