The effects of combined micron-/submicron-scale surface roughness and nanoscale features on cell proliferation and differentiation
Rolando A. Gittens,Taylor McLachlan,Rene Olivares-Navarrete,Ye Cai,Simon Berner,Rina Tannenbaum,Zvi Schwartz,Kenneth H. Sandhage,Barbara D. Boyan +8 more
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TLDR
The results suggested that the introduction of such nanoscale structures in combination with micro-/submicro-scale roughness improves osteoblast differentiation and local factor production, which indicates the potential for improved implant osseointegration in vivo.About:
This article is published in Biomaterials.The article was published on 2011-05-01 and is currently open access. It has received 703 citations till now. The article focuses on the topics: Surface roughness & Nanotopography.read more
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In vitro and in vivo comparisons of the porous Ti6Al4V alloys fabricated by the selective laser melting technique and a new sintering technique.
TL;DR: Under the study conditions, this new type of porous alloy prospects a good candidate for biomaterials, especially for repairing bone defects and arthroplasty in orthopedics.
Journal ArticleDOI
Positive effect of strontium-oxide layer on the osseointegration of moderately rough titanium surface in non-osteoporotic rabbits.
TL;DR: The strontium-oxide layer on the SLA surface has the potential to improve implant osseointegration in non-osteoporotic rabbits.
Journal ArticleDOI
The effect of microsized roughness in nano/microsized hierarchical surfaces replicated from a lotus leaf on the activities of osteoblast-like cells (MG63)
TL;DR: In this article, an electric-field-aided nano/micro-casting technique (FA-NCT) was employed to mimic a typical natural hierarchical structure, the lotus leaf.
Book ChapterDOI
Scientometric overview regarding the nanobiomaterials in dentistry
TL;DR: The major research areas were dental nanobiomaterials in teeth, dentin, and enamel as well as dental nano-osteoblasts and dental nanoimplants.
Journal ArticleDOI
Polydopamine-collagen complex to enhance the biocompatibility of polydimethylsiloxane substrates for sustaining long-term culture of L929 fibroblasts and tendon stem cells.
TL;DR: It is demonstrated that COL/PDA coating can effectively enhance the surface biocompatibility of PDMS as verified by the enhanced adhesion and long-term proliferation of L929 fibroblasts and TSCs.
References
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Influence of surface characteristics on bone integration of titanium implants. A histomorphometric study in miniature pigs.
Daniel Buser,Robert K. Schenk,S. G. Steinemann,Joseph P. Fiorellini,Christopher H. Fox,H. Stich +5 more
TL;DR: The extent of bone-implant interface is positively correlated with an increasing roughness of the implant surface, and hydroxylapatite (HA)-coated implants with 60-70% showed signs of resorption.
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Genetic regulation of osteoclast development and function
TL;DR: The past five years have witnessed important insights into osteoclast formation and function and many of these discoveries have been made through genetic experiments that involved the rare hereditary disorder osteopetrosis.
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Enhanced functions of osteoblasts on nanophase ceramics
TL;DR: The results of the present study provided the first evidence of enhanced long-term (on the order of days to weeks) functions of osteoblasts cultured on nanophase ceramics, and clearly represent a unique and promising class of orthopaedic/dental implant formulations with improved osseointegrative properties.
Journal ArticleDOI
Effect of titanium surface roughness on proliferation, differentiation, and protein synthesis of human osteoblast-like cells (MG63)
J. Y. Martin,Zvi Schwartz,Thomas W. Hummert,D. M. Schraub,J. Simpson,J. Lankford,David D Dean,David L. Cochran,Barbara D. Boyan +8 more
TL;DR: It is demonstrated that surface roughness alters osteoblast proliferation, differentiation, and matrix production in vitro and suggests that implant surfaceroughness may play a role in determining phenotypic expression of cells in vivo.
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