The effects of combined micron-/submicron-scale surface roughness and nanoscale features on cell proliferation and differentiation
Rolando A. Gittens,Taylor McLachlan,Rene Olivares-Navarrete,Ye Cai,Simon Berner,Rina Tannenbaum,Zvi Schwartz,Kenneth H. Sandhage,Barbara D. Boyan +8 more
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TLDR
The results suggested that the introduction of such nanoscale structures in combination with micro-/submicro-scale roughness improves osteoblast differentiation and local factor production, which indicates the potential for improved implant osseointegration in vivo.About:
This article is published in Biomaterials.The article was published on 2011-05-01 and is currently open access. It has received 703 citations till now. The article focuses on the topics: Surface roughness & Nanotopography.read more
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Dexamethasone-Loaded Bioactive Coatings on Medical Grade Stainless Steel Promote Osteointegration.
TL;DR: In this article, a multilayer bioactive coating based on carboxymethyl cellulose (CMC) and dexamethasone (DEX) was prepared on medical-grade stainless steel (AISI 316LVM).
Journal ArticleDOI
Bone marrow stromal cells are sensitive to discrete surface alterations in build and post-build modifications of bioinspired Ti6Al4V 3D-printed in vitro testing constructs.
TL;DR: In this article , the authors evaluated the relative contributions of build parameters and post-manufacturing modification techniques to cell responses that impact osseointegration in vivo by culturing human bone marrow stromal cells (MSCs).
OtherDOI
Laser Surface Engineering of Polymeric Materials for Enhanced Mesenchymal Stem Cell Adhesion and Growth
ElectricalPolarizationofTitanium SurfacesfortheEnhancementof OsteoblastDifferentiation
TL;DR: Results show that electricalpolarization applied directly through Ti substrates on which the cells are growing in theabsence of applied electrical currents may increase osteoblast differentiation and localfactor production in a voltage-dependent manner.
References
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Mechanical properties and the hierarchical structure of bone
TL;DR: Further investigations of mechanical properties at the "materials level", in addition to the studies at the 'structural level' are needed to fill the gap in present knowledge and to achieve a complete understanding of the mechanical properties of bone.
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Influence of surface characteristics on bone integration of titanium implants. A histomorphometric study in miniature pigs.
Daniel Buser,Robert K. Schenk,S. G. Steinemann,Joseph P. Fiorellini,Christopher H. Fox,H. Stich +5 more
TL;DR: The extent of bone-implant interface is positively correlated with an increasing roughness of the implant surface, and hydroxylapatite (HA)-coated implants with 60-70% showed signs of resorption.
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Genetic regulation of osteoclast development and function
TL;DR: The past five years have witnessed important insights into osteoclast formation and function and many of these discoveries have been made through genetic experiments that involved the rare hereditary disorder osteopetrosis.
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Enhanced functions of osteoblasts on nanophase ceramics
TL;DR: The results of the present study provided the first evidence of enhanced long-term (on the order of days to weeks) functions of osteoblasts cultured on nanophase ceramics, and clearly represent a unique and promising class of orthopaedic/dental implant formulations with improved osseointegrative properties.
Journal ArticleDOI
Effect of titanium surface roughness on proliferation, differentiation, and protein synthesis of human osteoblast-like cells (MG63)
J. Y. Martin,Zvi Schwartz,Thomas W. Hummert,D. M. Schraub,J. Simpson,J. Lankford,David D Dean,David L. Cochran,Barbara D. Boyan +8 more
TL;DR: It is demonstrated that surface roughness alters osteoblast proliferation, differentiation, and matrix production in vitro and suggests that implant surfaceroughness may play a role in determining phenotypic expression of cells in vivo.
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