The effects of combined micron-/submicron-scale surface roughness and nanoscale features on cell proliferation and differentiation
Rolando A. Gittens,Taylor McLachlan,Rene Olivares-Navarrete,Ye Cai,Simon Berner,Rina Tannenbaum,Zvi Schwartz,Kenneth H. Sandhage,Barbara D. Boyan +8 more
Reads0
Chats0
TLDR
The results suggested that the introduction of such nanoscale structures in combination with micro-/submicro-scale roughness improves osteoblast differentiation and local factor production, which indicates the potential for improved implant osseointegration in vivo.About:
This article is published in Biomaterials.The article was published on 2011-05-01 and is currently open access. It has received 703 citations till now. The article focuses on the topics: Surface roughness & Nanotopography.read more
Citations
More filters
Journal ArticleDOI
Indirect selective laser sintering-printed microporous biphasic calcium phosphate scaffold promotes endogenous bone regeneration via activation of ERK1/2 signaling.
Hao Zeng,Janak L. Pathak,Yusheng Shi,Jiabing Ran,Liang Liang,Qi Yan,Tao Wu,Qihang Fan,Mengxun Li,Yi Bai +9 more
TL;DR: An indirect selective laser sintering (SLS) printing strategy to fabricate 3D microporous BCP scaffolds maintains the physicochemical properties of BCP and possess the capacity to recruit host precursor cells to the defect site and promote the endogenous bone regeneration possibly via activation of ERK1/2 signaling.
Journal ArticleDOI
The response of osteoblastic MC3T3-E1 cells to micro- and nano-textured, hydrophilic and bioactive titanium surfaces.
Simone Lumetti,Edoardo Manfredi,Sara Ferraris,Silvia Maria Spriano,Giovanni Passeri,G. Ghiacci,Guido Maria Macaluso,Carlo Galli +7 more
TL;DR: Investigating the morphology and activity of the murine osteoblastic cell line MC3T3 on control smooth, commercially available rough (ZT) titanium discs, and on titanium samples obtained by modifying the ZT treatment protocol showed that ZTF and ZTM treatment protocols appeared to improve the basal sand-blasting/acid-etching ZT procedure with ZTM surfaces promoting the most mature stage of differentiation.
Journal ArticleDOI
Quantitative characterization of mineralized silk film remodeling during long-term osteoblast-osteoclast co-culture.
TL;DR: Film remodeled in co-culture demonstrated increased roughness parameters, fractal organization, and volume compared to films remodeled by osteoblasts alone, and shows promise for quantifying processes related to mineralized surfaces.
Journal ArticleDOI
TiO2 coating promotes human mesenchymal stem cell proliferation without the loss of their capacity for chondrogenic differentiation.
Salla Kaitainen,Anssi J. Mähönen,Reijo Lappalainen,Heikki Kröger,Mikko J. Lammi,Chengjuan Qu +5 more
TL;DR: TiO2 coating caused no significant differences in the proteoglycan and type II collagen staining of the pellets, or the expression of chondrocyte-specific genes in the chondrogenesis assay, suggesting that the proliferation of hMSCs could be significantly increased when cultured on TiO2-coated dishes without weakening their chONDrogenic differentiation capacity.
Journal ArticleDOI
Protein adsorption and cell behaviors on polycaprolactone film: The effect of surface topography
TL;DR: In this article, the effect of surface topologies on protein adsorption was studied using bovine serum albumin (BSA) as the biomolecule, and the results showed that proteins preferentially adsorbed onto rough surfaces.
References
More filters
Journal ArticleDOI
Mechanical properties and the hierarchical structure of bone
TL;DR: Further investigations of mechanical properties at the "materials level", in addition to the studies at the 'structural level' are needed to fill the gap in present knowledge and to achieve a complete understanding of the mechanical properties of bone.
Journal ArticleDOI
Influence of surface characteristics on bone integration of titanium implants. A histomorphometric study in miniature pigs.
Daniel Buser,Robert K. Schenk,S. G. Steinemann,Joseph P. Fiorellini,Christopher H. Fox,H. Stich +5 more
TL;DR: The extent of bone-implant interface is positively correlated with an increasing roughness of the implant surface, and hydroxylapatite (HA)-coated implants with 60-70% showed signs of resorption.
Journal ArticleDOI
Genetic regulation of osteoclast development and function
TL;DR: The past five years have witnessed important insights into osteoclast formation and function and many of these discoveries have been made through genetic experiments that involved the rare hereditary disorder osteopetrosis.
Journal ArticleDOI
Enhanced functions of osteoblasts on nanophase ceramics
TL;DR: The results of the present study provided the first evidence of enhanced long-term (on the order of days to weeks) functions of osteoblasts cultured on nanophase ceramics, and clearly represent a unique and promising class of orthopaedic/dental implant formulations with improved osseointegrative properties.
Journal ArticleDOI
Effect of titanium surface roughness on proliferation, differentiation, and protein synthesis of human osteoblast-like cells (MG63)
J. Y. Martin,Zvi Schwartz,Thomas W. Hummert,D. M. Schraub,J. Simpson,J. Lankford,David D Dean,David L. Cochran,Barbara D. Boyan +8 more
TL;DR: It is demonstrated that surface roughness alters osteoblast proliferation, differentiation, and matrix production in vitro and suggests that implant surfaceroughness may play a role in determining phenotypic expression of cells in vivo.
Related Papers (5)
Surface treatments of titanium dental implants for rapid osseointegration
Effects of titanium surface topography on bone integration: a systematic review
Ann Wennerberg,Tomas Albrektsson +1 more