The effects of combined micron-/submicron-scale surface roughness and nanoscale features on cell proliferation and differentiation
Rolando A. Gittens,Taylor McLachlan,Rene Olivares-Navarrete,Ye Cai,Simon Berner,Rina Tannenbaum,Zvi Schwartz,Kenneth H. Sandhage,Barbara D. Boyan +8 more
Reads0
Chats0
TLDR
The results suggested that the introduction of such nanoscale structures in combination with micro-/submicro-scale roughness improves osteoblast differentiation and local factor production, which indicates the potential for improved implant osseointegration in vivo.About:
This article is published in Biomaterials.The article was published on 2011-05-01 and is currently open access. It has received 703 citations till now. The article focuses on the topics: Surface roughness & Nanotopography.read more
Citations
More filters
Journal ArticleDOI
Interaction of Human Mesenchymal Stem Cells with Soft Nanocomposite Hydrogels Based on Polyethylene Glycol and Dendritic Polyglycerol
Rotsiniaina Randriantsilefisoa,Yong Hou,Yuanwei Pan,Jose Luis Cuellar Camacho,Michaël W. Kulka,Jianguang Zhang,Rainer Haag +6 more
TL;DR: Overall, this work addresses the need for a new alternative for hMSCs culture allowing the cells to differentiate exclusively into adipocytes by obtaining a patterned hydrogel nanocomposite with the stiffness of liver tissues without any molding process.
Journal ArticleDOI
A super-hydrophilic coating with a macro/micro/nano triple hierarchical structure on titanium by two-step micro-arc oxidation treatment for biomedical applications
TL;DR: In this article, a super-hydrophilic coating with a macro/micro/nano triple hierarchical structure was prepared on titanium surface by a two-step micro-arc oxidation (MAO) treatment consisting of macropores (100-300μm), microslots (3-10μm) and submicro/nanopores (80-200μnm).
Journal ArticleDOI
Silk–PVA Hybrid Nanofibrous Scaffolds for Enhanced Primary Human Meniscal Cell Proliferation
Mamatha M. Pillai,J. Gopinathan,B. Indumathi,Y R Manjoosha,K. Santosh Sahanand,B. K. Dinakar Rai,Rajendran Selvakumar,Amitava Bhattacharyya +7 more
TL;DR: Results clearly indicate that a blend of SF:PVA at 3:1 ratio is suitable for meniscus cell proliferation when compared to pure SF-PVA nanofibers.
Journal ArticleDOI
Surface modification induced phase transformation and structure variation on the rapidly solidified recast layer of titanium
Ming Hung Tsai,Chiung Fang Haung,Chiung Fang Haung,Shih Shiun Shyu,Yen Ru Chou,Ming Hong Lin,Pei Wen Peng,Keng Liang Ou,Chih Hua Yu +8 more
TL;DR: In this paper, the nano-structural and biological properties of laser-modified samples were investigated by means of optical microscope, electron microscope, X-ray diffraction, surface roughness instrument, contact angle and cell cytotoxicity assay.
Journal ArticleDOI
Fabrication, multi-scale characterization and in-vitro evaluation of porous hybrid bioactive glass polymer-coated scaffolds for bone tissue engineering.
Adrian Chlanda,Przemysław Oberbek,Marcin Heljak,Ewa Kijeńska-Gawrońska,Tomasz Bolek,Michał Gloc,Łukasz John,Mateusz Janeta,M.J. Woźniak +8 more
TL;DR: The findings show that after polymer addition, architecture, topography and surface properties of the scaffolds were changed and promoted favoured behaviour of the cells.
References
More filters
Journal ArticleDOI
Mechanical properties and the hierarchical structure of bone
TL;DR: Further investigations of mechanical properties at the "materials level", in addition to the studies at the 'structural level' are needed to fill the gap in present knowledge and to achieve a complete understanding of the mechanical properties of bone.
Journal ArticleDOI
Influence of surface characteristics on bone integration of titanium implants. A histomorphometric study in miniature pigs.
Daniel Buser,Robert K. Schenk,S. G. Steinemann,Joseph P. Fiorellini,Christopher H. Fox,H. Stich +5 more
TL;DR: The extent of bone-implant interface is positively correlated with an increasing roughness of the implant surface, and hydroxylapatite (HA)-coated implants with 60-70% showed signs of resorption.
Journal ArticleDOI
Genetic regulation of osteoclast development and function
TL;DR: The past five years have witnessed important insights into osteoclast formation and function and many of these discoveries have been made through genetic experiments that involved the rare hereditary disorder osteopetrosis.
Journal ArticleDOI
Enhanced functions of osteoblasts on nanophase ceramics
TL;DR: The results of the present study provided the first evidence of enhanced long-term (on the order of days to weeks) functions of osteoblasts cultured on nanophase ceramics, and clearly represent a unique and promising class of orthopaedic/dental implant formulations with improved osseointegrative properties.
Journal ArticleDOI
Effect of titanium surface roughness on proliferation, differentiation, and protein synthesis of human osteoblast-like cells (MG63)
J. Y. Martin,Zvi Schwartz,Thomas W. Hummert,D. M. Schraub,J. Simpson,J. Lankford,David D Dean,David L. Cochran,Barbara D. Boyan +8 more
TL;DR: It is demonstrated that surface roughness alters osteoblast proliferation, differentiation, and matrix production in vitro and suggests that implant surfaceroughness may play a role in determining phenotypic expression of cells in vivo.
Related Papers (5)
Surface treatments of titanium dental implants for rapid osseointegration
Effects of titanium surface topography on bone integration: a systematic review
Ann Wennerberg,Tomas Albrektsson +1 more