The effects of combined micron-/submicron-scale surface roughness and nanoscale features on cell proliferation and differentiation
Rolando A. Gittens,Taylor McLachlan,Rene Olivares-Navarrete,Ye Cai,Simon Berner,Rina Tannenbaum,Zvi Schwartz,Kenneth H. Sandhage,Barbara D. Boyan +8 more
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TLDR
The results suggested that the introduction of such nanoscale structures in combination with micro-/submicro-scale roughness improves osteoblast differentiation and local factor production, which indicates the potential for improved implant osseointegration in vivo.About:
This article is published in Biomaterials.The article was published on 2011-05-01 and is currently open access. It has received 703 citations till now. The article focuses on the topics: Surface roughness & Nanotopography.read more
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A Literature Review on Nano-Modified Implant Surfaces
TL;DR: The nano-modified surface has little cytotoxicity, stimulates osteoblast proliferation and differentiation, and decreases soft tissue intervention by interrupting the proliferation of fibroblast, however, the actual effect in vivo is limited, due to the distance of effect as discussed by the authors.
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Surface Modification of Titanium by Micro-Arc Oxidation in Promoting Schwann Cell Proliferation and Secretion of Neurotrophic Factors
TL;DR: In this article , the effect of micro-arc oxidation modified titanium surface on Schwann cells has not been studied, which is of great significance for nerve regeneration around implants and improvement of osseoperception.
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Dependence of Morphology, Structure, Composition and Biocompatibility of Ca- and P-Doped TiO2 Coatings on PEO Process Parameters
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Surface treatment by plasma carbonitriding of Ti-6Al-4V alloy for dental implants
Jailson de Jesus,Enori Gemelli,Fabio Nery,Luís César Fontana,Nelson Heriberto Almeida Camargo +4 more
TL;DR: In this article, the influence of carbonitriding on the surface roughness and contact angle of Ti6Al4V treated in a Ar / N2 / CH4 plasma for 3 h and 6 h at 600 °C was investigated.
References
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Influence of surface characteristics on bone integration of titanium implants. A histomorphometric study in miniature pigs.
Daniel Buser,Robert K. Schenk,S. G. Steinemann,Joseph P. Fiorellini,Christopher H. Fox,H. Stich +5 more
TL;DR: The extent of bone-implant interface is positively correlated with an increasing roughness of the implant surface, and hydroxylapatite (HA)-coated implants with 60-70% showed signs of resorption.
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Genetic regulation of osteoclast development and function
TL;DR: The past five years have witnessed important insights into osteoclast formation and function and many of these discoveries have been made through genetic experiments that involved the rare hereditary disorder osteopetrosis.
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Enhanced functions of osteoblasts on nanophase ceramics
TL;DR: The results of the present study provided the first evidence of enhanced long-term (on the order of days to weeks) functions of osteoblasts cultured on nanophase ceramics, and clearly represent a unique and promising class of orthopaedic/dental implant formulations with improved osseointegrative properties.
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Effect of titanium surface roughness on proliferation, differentiation, and protein synthesis of human osteoblast-like cells (MG63)
J. Y. Martin,Zvi Schwartz,Thomas W. Hummert,D. M. Schraub,J. Simpson,J. Lankford,David D Dean,David L. Cochran,Barbara D. Boyan +8 more
TL;DR: It is demonstrated that surface roughness alters osteoblast proliferation, differentiation, and matrix production in vitro and suggests that implant surfaceroughness may play a role in determining phenotypic expression of cells in vivo.
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