The effects of combined micron-/submicron-scale surface roughness and nanoscale features on cell proliferation and differentiation
Rolando A. Gittens,Taylor McLachlan,Rene Olivares-Navarrete,Ye Cai,Simon Berner,Rina Tannenbaum,Zvi Schwartz,Kenneth H. Sandhage,Barbara D. Boyan +8 more
Reads0
Chats0
TLDR
The results suggested that the introduction of such nanoscale structures in combination with micro-/submicro-scale roughness improves osteoblast differentiation and local factor production, which indicates the potential for improved implant osseointegration in vivo.About:
This article is published in Biomaterials.The article was published on 2011-05-01 and is currently open access. It has received 703 citations till now. The article focuses on the topics: Surface roughness & Nanotopography.read more
Citations
More filters
Molecular mechanism mediating proliferation, defferentiation interralationships during progressie development of the osteoblast phenotype
G S Stein,J B Lian +1 more
TL;DR: This work states that for many years, bone was defined anatomically and examined largely in a descriptive manner by ultrastructural analysis and by biochemical and histochemical methods, but now, complemented by an increased knowledge of molecular mechanisms that are associated with and regulate expression of genes encoding phenotypic compone...
Journal ArticleDOI
Review on titanium and titanium based alloys as biomaterials for orthopaedic applications.
Manmeet Kaur,Kulvir Singh +1 more
TL;DR: Various attempts to improve upon these properties like different processing routes, surface modifications have been inculcated in the paper to provide an insight into the extent of research and effort that has been put into developing a highly superior titanium orthopaedic implant.
Journal ArticleDOI
Significance of calcium phosphate coatings for the enhancement of new bone osteogenesis – A review ☆
TL;DR: A systematic analysis of results available from in vitro, in vivo and clinical trials on the effects of biocompatible calcium phosphate (CaP) coatings is presented and the future research and use of these devices is discussed.
Journal ArticleDOI
A review on the wettability of dental implant surfaces II: Biological and clinical aspects
Rolando A. Gittens,Lutz Scheideler,Frank Rupp,Sharon L. Hyzy,Juergen Geis-Gerstorfer,Zvi Schwartz,Barbara D. Boyan +6 more
TL;DR: This review provides a general overview of the available information about the contact angle values of experimental and of marketed implant surfaces, some of the techniques used to modify surface wettability of implants, and results from in vitro and clinical studies.
Journal ArticleDOI
Additively manufactured metallic porous biomaterials based on minimal surfaces: A unique combination of topological, mechanical, and mass transport properties
F. S. L. Bobbert,Karel Lietaert,Ali Eftekhari,Behdad Pouran,S.M. Ahmadi,Harrie Weinans,Amir A. Zadpoor +6 more
TL;DR: Rationally designed and additively manufactured porous metallic biomaterials based on four different types of triply periodic minimal surfaces that mimic the properties of bone to an unprecedented level of multi-physics detail exhibit an interesting combination of topological, mechanical, and mass transport properties.
References
More filters
Journal ArticleDOI
Osteoblast-mediated mineral deposition in culture is dependent on surface microtopography.
Barbara D. Boyan,Lynda F. Bonewald,Eleftherios P. Paschalis,C. H. Lohmann,C. H. Lohmann,Jennifer Rosser,David L. Cochran,David D Dean,Zvi Schwartz,Adele L. Boskey,Adele L. Boskey +10 more
TL;DR: The hypothesis that mineralized bone nodule formation in response to osteotropic agents such as bone morphogenetic protein-2 (BMP-2) and dexamethasone is also influenced by surface microtopography is tested and interactions between growth factor or hormone and surfaceMicrotopography can modulate bone cell differentiation and mineralization is demonstrated.
Journal ArticleDOI
Osteoblast-like cells are sensitive to submicron-scale surface structure.
TL;DR: Results show that micron-scale topography modulates cell number, cell morphology and prostaglandin E2 (PGE2) in the presence of the appropriate microtopography, and submicron- scale rugosity modulates differentiation and transforming growth factor-beta1 (TGF- beta1) levels.
Journal ArticleDOI
The effects of implant surface nanoscale features on osteoblast-specific gene expression.
Gustavo Mendonça,Gustavo Mendonça,Daniela Baccelli Silveira Mendonça,Daniela Baccelli Silveira Mendonça,L. G. P. Simoes,André Luiz Araújo,Edson R. Leite,Wagner R. Duarte,Francisco J. L. Aragão,Lyndon F. Cooper +9 more
TL;DR: N nanostructured surfaces produced using aluminum oxide significantly enhanced the hMSC gene expression representative of osteoblast differentiation, suggesting nanoscale features on Ti implant substrates may improve the osseointegration response by altering adherent cell response.
Journal ArticleDOI
The effect of hydrofluoric acid treatment of TiO2 grit blasted titanium implants on adherent osteoblast gene expression in vitro and in vivo.
TL;DR: The increased levels of RUNX-2 in cells adherent to theTiO2/HF surfaces suggest that the additional HF treatment of the TiO2 grit blasted surface results in surface properties that support adherent cell osteoinduction.
Journal ArticleDOI
The effect of discrete calcium phosphate nanocrystals on bone-bonding to titanium surfaces.
TL;DR: It is concluded that titanium implant surfaces can be rendered bone-bonding by an increase in the complexity of the surface topography.
Related Papers (5)
Surface treatments of titanium dental implants for rapid osseointegration
Effects of titanium surface topography on bone integration: a systematic review
Ann Wennerberg,Tomas Albrektsson +1 more