The effects of combined micron-/submicron-scale surface roughness and nanoscale features on cell proliferation and differentiation
Rolando A. Gittens,Taylor McLachlan,Rene Olivares-Navarrete,Ye Cai,Simon Berner,Rina Tannenbaum,Zvi Schwartz,Kenneth H. Sandhage,Barbara D. Boyan +8 more
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TLDR
The results suggested that the introduction of such nanoscale structures in combination with micro-/submicro-scale roughness improves osteoblast differentiation and local factor production, which indicates the potential for improved implant osseointegration in vivo.About:
This article is published in Biomaterials.The article was published on 2011-05-01 and is currently open access. It has received 703 citations till now. The article focuses on the topics: Surface roughness & Nanotopography.read more
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Effect of nano-structured bioceramic surface on osteogenic differentiation of adipose derived stem cells.
Lunguo Xia,Kaili Lin,Xinquan Jiang,Bing Fang,Yuanjin Xu,Jiaqiang Liu,Deliang Zeng,Maolin Zhang,Xiuli Zhang,Jiang Chang,Zhiyuan Zhang +10 more
TL;DR: The results suggest that HAp bioceramic scaffolds with micro-nano-hybrid surface can act as cell carrier for ASCs, and consequently combine with ASCs to construct vascularized tissue-engineered bone.
Journal ArticleDOI
Osteoinductive hydroxyapatite-coated titanium implants.
TL;DR: Data in non-human primates indicate that geometrically-constructed plasma-sprayed titanium implants are per se osteogenic, the concavities providing a unique microenvironment to initiate bone differentiation by induction.
Journal ArticleDOI
Ceramics and Ceramic Coatings in Orthopaedics
TL;DR: Advanced bioceramics and coatings are expected to have increasing use in orthopaedics because of their unique combination and range of properties including strength and toughness, hardness and wear resistance, biocompatibility, bacteriostasis, and osseointegration.
Journal ArticleDOI
Cell microenvironment engineering and monitoring for tissue engineering and regenerative medicine: the recent advances.
Julien Barthes,Hayriye Özçelik,Mathilde Hindié,Albana Ndreu-Halili,Anwarul Hasan,Nihal Engin Vrana +5 more
TL;DR: In this paper, the authors focus on the different aspects of cell microenvironment such as surface micro-, nanotopography, extracellular matrix composition and distribution, controlled release of soluble factors, and mechanical stress/strain conditions and how these aspects and their interactions can be used to achieve a higher degree of control over cellular activities.
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Osseointegration: Hierarchical designing encompassing the macrometer, micrometer, and nanometer length scales
TL;DR: A proportional inconsistency in findings hitherto encountered warrants a call for appropriate multivariable study designing to ensure that adequate data collection will enable osseointegration maximization and/or optimization, which will possibly lead to the engineering of endosteal implant designs that can be immediately placed/loaded regardless of patient dependent conditions.
References
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Mechanical properties and the hierarchical structure of bone
TL;DR: Further investigations of mechanical properties at the "materials level", in addition to the studies at the 'structural level' are needed to fill the gap in present knowledge and to achieve a complete understanding of the mechanical properties of bone.
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Influence of surface characteristics on bone integration of titanium implants. A histomorphometric study in miniature pigs.
Daniel Buser,Robert K. Schenk,S. G. Steinemann,Joseph P. Fiorellini,Christopher H. Fox,H. Stich +5 more
TL;DR: The extent of bone-implant interface is positively correlated with an increasing roughness of the implant surface, and hydroxylapatite (HA)-coated implants with 60-70% showed signs of resorption.
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Genetic regulation of osteoclast development and function
TL;DR: The past five years have witnessed important insights into osteoclast formation and function and many of these discoveries have been made through genetic experiments that involved the rare hereditary disorder osteopetrosis.
Journal ArticleDOI
Enhanced functions of osteoblasts on nanophase ceramics
TL;DR: The results of the present study provided the first evidence of enhanced long-term (on the order of days to weeks) functions of osteoblasts cultured on nanophase ceramics, and clearly represent a unique and promising class of orthopaedic/dental implant formulations with improved osseointegrative properties.
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Effect of titanium surface roughness on proliferation, differentiation, and protein synthesis of human osteoblast-like cells (MG63)
J. Y. Martin,Zvi Schwartz,Thomas W. Hummert,D. M. Schraub,J. Simpson,J. Lankford,David D Dean,David L. Cochran,Barbara D. Boyan +8 more
TL;DR: It is demonstrated that surface roughness alters osteoblast proliferation, differentiation, and matrix production in vitro and suggests that implant surfaceroughness may play a role in determining phenotypic expression of cells in vivo.
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