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The Health Effects of Cannabis and Cannabinoids: The Current State of Evidence and Recommendations for Research

Eric Groce
- Vol. 104, Iss: 4, pp 32-32
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TLDR
Despite increased cannabis use and a changing state-level policy landscape, conclusive evidence regarding the shortand long-term health effects—both harms and benefits—of cannabis use remains elusive.
Abstract
Recent years have seen a rapid rise in the medical and recreational use of cannabis: a broad term that can be used to describe the various products and chemical compounds (e.g., marijuana, cannabinoids) derived from different species of the cannabis plant. Despite increased cannabis use and a changing state-level policy landscape, conclusive evidence regarding the shortand long-term health effects—both harms and benefits—of cannabis use remains elusive.

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Citations
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Journal ArticleDOI

Epidemiology of Adult DSM-5 Major Depressive Disorder and Its Specifiers in the United States.

TL;DR: Both anxious/distressed specifier and mixed-features specifier were associated with early onset, poor course and functioning, and suicidality in US adults, and much remains to be learned about the DSM-5 MDD specifiers in the general population.
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Association of Cannabis Use in Adolescence and Risk of Depression, Anxiety, and Suicidality in Young Adulthood: A Systematic Review and Meta-analysis.

TL;DR: Although individual-level risk remains moderate to low and results from this study should be confirmed in future adequately powered prospective studies, the high prevalence of adolescents consuming cannabis generates a large number of young people who could develop depression and suicidality attributable to cannabis.
Journal ArticleDOI

US Epidemiology of Cannabis Use and Associated Problems

TL;DR: An overview of the changing US epidemiology of cannabis use and associated problems suggests national increases in cannabis potency, prenatal and unintentional childhood exposure; and in adults, increased use, CUD, cannabis-related emergency room visits, and fatal vehicle crashes.
Journal ArticleDOI

Cannabis and cannabinoids for the treatment of people with chronic noncancer pain conditions: a systematic review and meta-analysis of controlled and observational studies.

TL;DR: It seems unlikely that cannabinoids are highly effective medicines for CNCP, as effects suggest that number needed to treat to benefit is high, and number neededto treat to harm is low, with limited impact on other domains.
Journal ArticleDOI

Cannabinoids for the treatment of mental disorders and symptoms of mental disorders: a systematic review and meta-analysis

TL;DR: There is scarce evidence to suggest that cannabinoids improve depressive disorders and symptoms, anxiety disorders, attention-deficit hyperactivity disorder, Tourette syndrome, post-traumatic stress disorder, or psychosis.
References
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Journal ArticleDOI

Cardiovascular and Metabolic Considerations in Prolonged Cannabinoid Administration in Man

TL;DR: Cardiovascular effects of acute Δ9‐tetrahydrocannabinol (THC) administration included increased sympathetic and reduced parasympathetic tone, although sympathetic reflex responses were impaired.
Journal ArticleDOI

Pulmonary function in cannabis users: Support for a clinical trial of the vaporizer.

TL;DR: Preliminary data reveal meaningful improvements in respiratory function, suggesting that a randomized clinical trial of the cannabis vaporizer is warranted and has potential for the administration of medical cannabis and as a harm reduction technique.
Journal ArticleDOI

Natural course of cannabis use disorders.

TL;DR: CUDs are relatively common, affecting about one out of five persons in the OADP sample prior to the age of 30 years, and eventual recovery from index CUD episodes is the norm, although about 30% of those with a CUD exhibit a generally persistent pattern of problematic use extending 7 years or longer.
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Directions of the relationship between substance use and depressive symptoms from adolescence to young adulthood

TL;DR: Results indicate a bidirectional relationship between smoking and depressive symptoms for females and for males, there was evidence supporting self-medication with marijuana and for smoking being associated with later increases in depressive symptoms.
Journal ArticleDOI

Quality of life and risk of psychiatric disorders among regular users of alcohol, nicotine, and cannabis: An analysis of the National Epidemiological Survey on Alcohol and Related Conditions (NESARC)

TL;DR: Examining current and future quality of life and risk of psychiatric disorders among past-year regular (weekly) users of alcohol, nicotine, and cannabis found that regular nicotine use predicted onset of anxiety, depressive, and bipolar disorders, and regular alcohol use predicted lower risk of these disorders.
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