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The Health Effects of Cannabis and Cannabinoids: The Current State of Evidence and Recommendations for Research

Eric Groce
- Vol. 104, Iss: 4, pp 32-32
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TLDR
Despite increased cannabis use and a changing state-level policy landscape, conclusive evidence regarding the shortand long-term health effects—both harms and benefits—of cannabis use remains elusive.
Abstract
Recent years have seen a rapid rise in the medical and recreational use of cannabis: a broad term that can be used to describe the various products and chemical compounds (e.g., marijuana, cannabinoids) derived from different species of the cannabis plant. Despite increased cannabis use and a changing state-level policy landscape, conclusive evidence regarding the shortand long-term health effects—both harms and benefits—of cannabis use remains elusive.

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Citations
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Journal ArticleDOI

Epidemiology of Adult DSM-5 Major Depressive Disorder and Its Specifiers in the United States.

TL;DR: Both anxious/distressed specifier and mixed-features specifier were associated with early onset, poor course and functioning, and suicidality in US adults, and much remains to be learned about the DSM-5 MDD specifiers in the general population.
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Association of Cannabis Use in Adolescence and Risk of Depression, Anxiety, and Suicidality in Young Adulthood: A Systematic Review and Meta-analysis.

TL;DR: Although individual-level risk remains moderate to low and results from this study should be confirmed in future adequately powered prospective studies, the high prevalence of adolescents consuming cannabis generates a large number of young people who could develop depression and suicidality attributable to cannabis.
Journal ArticleDOI

US Epidemiology of Cannabis Use and Associated Problems

TL;DR: An overview of the changing US epidemiology of cannabis use and associated problems suggests national increases in cannabis potency, prenatal and unintentional childhood exposure; and in adults, increased use, CUD, cannabis-related emergency room visits, and fatal vehicle crashes.
Journal ArticleDOI

Cannabis and cannabinoids for the treatment of people with chronic noncancer pain conditions: a systematic review and meta-analysis of controlled and observational studies.

TL;DR: It seems unlikely that cannabinoids are highly effective medicines for CNCP, as effects suggest that number needed to treat to benefit is high, and number neededto treat to harm is low, with limited impact on other domains.
Journal ArticleDOI

Cannabinoids for the treatment of mental disorders and symptoms of mental disorders: a systematic review and meta-analysis

TL;DR: There is scarce evidence to suggest that cannabinoids improve depressive disorders and symptoms, anxiety disorders, attention-deficit hyperactivity disorder, Tourette syndrome, post-traumatic stress disorder, or psychosis.
References
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Journal ArticleDOI

Notes from the Field: Death Following Ingestion of an Edible Marijuana Product--Colorado, March 2014.

TL;DR: The autopsy, performed 29 hours after time of death, found marijuana intoxication as a chief contributing factor and this was the first reported death in Colorado linked to marijuana consumption without evidence of polysubstance use since the state approved recreational use of marijuana in 2012.
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Chronic inflammation and the role for cofactors (hepatitis C, drug abuse, antiretroviral drug toxicity, aging) in HAND persistence.

TL;DR: Effectively managing co-morbid conditions in individuals with and without HAND is critical for improving neurocognitive outcomes and decreasing HIV-associated morbidity.
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Prolonged Coma in a Child Due to Hashish Ingestion with Quantitation of THC Metabolites in Urine

TL;DR: Significant ingestion of cannabinoid-containing substances is capable of causing prolonged symptoms (including coma) in children, including coma, in children.
Journal ArticleDOI

Determination of the relative percentage distribution of THCA and Δ9-THC in herbal cannabis seized in Austria – Impact of different storage temperatures on stability

TL;DR: It was shown successfully that high storage temperatures led to a more rapid and complete decomposition of THCA to Δ(9)-THC while at low temperatures only slight or no changes of the percentage distribution were determined.
Journal ArticleDOI

Effect of Blood Collection Time on Measured Δ9-Tetrahydrocannabinol Concentrations: Implications for Driving Interpretation and Drug Policy

TL;DR: Forensic blood THC concentrations may be lower than common per se cutoffs despite greatly exceeding them while driving, and residual THC (from previous self-administration) was present, which rapidly decreased to preinhalation baselines and fluctuated around them.
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