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Open AccessJournal ArticleDOI

The Health Effects of Cannabis and Cannabinoids: The Current State of Evidence and Recommendations for Research

Eric Groce
- Vol. 104, Iss: 4, pp 32-32
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TLDR
Despite increased cannabis use and a changing state-level policy landscape, conclusive evidence regarding the shortand long-term health effects—both harms and benefits—of cannabis use remains elusive.
Abstract
Recent years have seen a rapid rise in the medical and recreational use of cannabis: a broad term that can be used to describe the various products and chemical compounds (e.g., marijuana, cannabinoids) derived from different species of the cannabis plant. Despite increased cannabis use and a changing state-level policy landscape, conclusive evidence regarding the shortand long-term health effects—both harms and benefits—of cannabis use remains elusive.

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Citations
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Journal ArticleDOI

Epidemiology of Adult DSM-5 Major Depressive Disorder and Its Specifiers in the United States.

TL;DR: Both anxious/distressed specifier and mixed-features specifier were associated with early onset, poor course and functioning, and suicidality in US adults, and much remains to be learned about the DSM-5 MDD specifiers in the general population.
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Association of Cannabis Use in Adolescence and Risk of Depression, Anxiety, and Suicidality in Young Adulthood: A Systematic Review and Meta-analysis.

TL;DR: Although individual-level risk remains moderate to low and results from this study should be confirmed in future adequately powered prospective studies, the high prevalence of adolescents consuming cannabis generates a large number of young people who could develop depression and suicidality attributable to cannabis.
Journal ArticleDOI

US Epidemiology of Cannabis Use and Associated Problems

TL;DR: An overview of the changing US epidemiology of cannabis use and associated problems suggests national increases in cannabis potency, prenatal and unintentional childhood exposure; and in adults, increased use, CUD, cannabis-related emergency room visits, and fatal vehicle crashes.
Journal ArticleDOI

Cannabis and cannabinoids for the treatment of people with chronic noncancer pain conditions: a systematic review and meta-analysis of controlled and observational studies.

TL;DR: It seems unlikely that cannabinoids are highly effective medicines for CNCP, as effects suggest that number needed to treat to benefit is high, and number neededto treat to harm is low, with limited impact on other domains.
Journal ArticleDOI

Cannabinoids for the treatment of mental disorders and symptoms of mental disorders: a systematic review and meta-analysis

TL;DR: There is scarce evidence to suggest that cannabinoids improve depressive disorders and symptoms, anxiety disorders, attention-deficit hyperactivity disorder, Tourette syndrome, post-traumatic stress disorder, or psychosis.
References
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Journal ArticleDOI

A community based investigation of the association between cannabis use, injuries and accidents.

TL;DR: Cannabis use was associated with both minor injuries and accidents, particularly among those with high levels of other associated risk factors, and with a significant detrimental impact on safety.
Journal ArticleDOI

Comorbid trajectories of substance use as predictors of Antisocial Personality Disorder, Major Depressive Episode, and Generalized Anxiety Disorder.

TL;DR: In a large, community-based sample, long-term concurrent use of more than one substance was associated with both externalizing and internalizing psychiatric disorders in adulthood.
Journal ArticleDOI

Drug Use, Workplace Accidents and Employee Turnover:

TL;DR: Using data from a large, representative sample of the U.S. population, a detailed analysis of the relationships among drug use, work- related accidents, and employee turnover indicates that various measures of drug use are not associated with work-related accidents.
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Combined immunomodulating properties of 3,4-methylenedioxymethamphetamine (MDMA) and cannabis in humans.

TL;DR: It is confirmed that long-term alterations in immunological homeostasis may result in general health status impairment and subsequent increased susceptibility to infection and immune-related disorders.
Journal ArticleDOI

Does Change in Cannabis Use in Established Psychosis Affect Clinical Outcome

TL;DR: Evidence of an association between cannabis dose and psychotic symptoms was not found, although greater cannabis dose was associated with worse psychosocial functioning, albeit with small effect size.
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