The multifactorial role of the 3Rs in shifting the harm-benefit analysis in animal models of disease.
Reads0
Chats0
TLDR
Increased investment and activity in the 3Rs is delivering new research models, tools and approaches with reduced reliance on animal use, improved animal welfare, and improved scientific and predictive value.About:
This article is published in European Journal of Pharmacology.The article was published on 2015-07-15 and is currently open access. It has received 125 citations till now.read more
Citations
More filters
Journal ArticleDOI
Galleria mellonella (greater wax moth) larvae as a model for antibiotic susceptibility testing and acute toxicity trials
TL;DR: It is found that G. mellonella larvae can be used in infectivity trials and toxicity testing, and that these assays represent an inexpensive and readily executable alternative to testing in rodents.
Journal ArticleDOI
Reduced Frizzled Receptor 4 Expression Prevents WNT/β-Catenin-driven Alveolar Lung Repair in Chronic Obstructive Pulmonary Disease
Wioletta Skronska-Wasek,Kathrin Mutze,Hoeke A. Baarsma,Ken R. Bracke,Hani N. Alsafadi,Mareike Lehmann,Rita Costa,Mariano Stornaiuolo,Ettore Novellino,Guy Brusselle,Darcy E. Wagner,Ali Önder Yildirim,Melanie Königshoff +12 more
TL;DR: Reduced FZD4 expression in COPD contributes to impaired alveolar repair capacity and led to induction of WNT/&bgr;‐catenin signaling and expression of elastogenic components in three‐dimensional lung tissue cultures ex vivo.
Journal ArticleDOI
Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells
Jon S. Odorico,James F. Markmann,Douglas A. Melton,Julia L. Greenstein,Albert Hwa,Cristina Nostro,Alireza Rezania,Jose Oberholzer,Daniel Pipeleers,Luhan Yang,Chad A. Cowan,Danwei Huangfu,Dieter Egli,Uri Ben-David,Ludovic Vallier,Shane T. Grey,Qizhi Tang,Bart O. Roep,C Ricordi,Ali Naji,Giuseppe Orlando,Daniel G. Anderson,Mark C. Poznansky,Barbara Ludwig,Alice A. Tomei,Dale L. Greiner,Melanie L. Graham,Melissa K. Carpenter,Giovanni Migliaccio,Kevin A. D'Amour,Bernhard J. Hering,Lorenzo Piemonti,Thierry Berney,Michael R. Rickels,Thomas W.H. Kay,Ann Jensen Adams +35 more
TL;DR: Current technology, recent significant breakthroughs, unmet needs and roadblocks to stem cell-derived beta cell therapies, with the aim of spurring future preclinical collaborative investigations and progress toward the clinical application of stem cell -derived beta cells are highlighted.
Journal ArticleDOI
Developing a collaborative agenda for humanities and social scientific research on laboratory animal science and welfare
Gail Davies,Beth Greenhough,Pru Hobson-West,Robert G. W. Kirk,Ken Applebee,Laura Bellingan,Manuel Berdoy,Henry Buller,Helen J. Cassaday,Keith Davies,Daniela Diefenbacher,Tone Druglitrø,Maria Paula Escobar,Carrie Friese,Kathrin Herrmann,Amy Hinterberger,Wendy J. Jarrett,Kimberley Jayne,Adam M. Johnson,Elizabeth R. Johnson,Timm Konold,Matthew C. Leach,Sabina Leonelli,David I. Lewis,Elliot Lilley,Emma R. Longridge,Carmen McLeod,Mara Miele,Nicole C. Nelson,Elisabeth H. Ormandy,Helen Pallett,Lonneke Poort,Pandora Pound,Edmund Ramsden,Emma Roe,Helen Scalway,Astrid Schrader,Chris J. Scotton,Cheryl L. Scudamore,Jane A. Smith,Lucy Whitfield,Sarah Wolfensohn +41 more
TL;DR: The process outlined below underlines the value of interdisciplinary exchange for improving communication across different research cultures and identifies ways of enhancing the effectiveness of future research at the interface between the humanities, social sciences, science and science policy.
Journal ArticleDOI
The welfare and ethics of research involving wild animals: A primer
Carl D. Soulsbury,Helen Gray,Lauren M. Smith,Victoria A. Braithwaite,Sheena C. Cotter,Robert W. Elwood,Anna V. Wilkinson,Lisa M. Collins +7 more
TL;DR: In this article, the authors discuss issues associated with the capture, handling, housing and experimental approaches for species occupying varied habitats, in both vertebrates and invertebrates (principally insects, crustaceans and molluscs).
References
More filters
Journal ArticleDOI
Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research
TL;DR: Most of the papers surveyed did not report using randomisation or blinding to reduce bias in animal selection and outcome assessment, consistent with reviews of many research areas, including clinical studies, published in recent years.
Book
The principles of humane experimental technique
W. M. S. Russell,R. L. Burch +1 more
TL;DR: The Principles of Humane Experimental Technique as mentioned in this paper, by W. M. S. Russell and R. L. Burch, 1959, London: Methuen & Co. Limited.
Journal ArticleDOI
Can the pharmaceutical industry reduce attrition rates
Ismail Kola,John Landis +1 more
TL;DR: The pharmaceutical industry faces considerable challenges, both politically and fiscally, and the fiscal pressures that face the industry from the perspective of R&D are dealt with.
Journal ArticleDOI
Drug development: Raise standards for preclinical cancer research
C. Glenn Begley,Lee M. Ellis +1 more
TL;DR: C. Glenn Begley and Lee M. Ellis propose how methods, publications and incentives must change if patients are to benefit.