The Pathogenesis of Extraintestinal Manifestations: Implications for IBD Research, Diagnosis, and Therapy.
Charlotte Hedin,Stephan R. Vavricka,Andrew J. Stagg,Alain M. Schoepfer,Tim Raine,Lluís Puig,U Pleyer,Alexander A. Navarini,A E van der Meulen-de Jong,Jochen Maul,K.H. Katsanos,A Kagramanova,Thomas Greuter,Thomas Greuter,Yago Gonzalez-Lama,F. A. van Gaalen,Pierre Ellul,Johan Burisch,Dominik Bettenworth,M D Becker,Giorgos Bamias,Florian Rieder +21 more
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This article reports on the sixth scientific workshop of the European Crohn's and Colitis Organisation [ECCO] on the pathogenesis of extraintestinal manifestations [EIMs] in inflammatory bowel disease [IBD].Abstract:
This article reports on the sixth scientific workshop of the European Crohn's and Colitis Organisation [ECCO] on the pathogenesis of extraintestinal manifestations [EIMs] in inflammatory bowel disease [IBD]. This paper has been drafted by 15 ECCO members and 6 external experts [in rheumatology, dermatology, ophthalmology, and immunology] from 10 European countries and the USA. Within the workshop, contributors formed subgroups to address specific areas. Following a comprehensive literature search, the supporting text was finalized under the leadership of the heads of the working groups before being integrated by the group consensus leaders.read more
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A Review of Neutrophil Extracellular Traps (NETs) in Disease: Potential Anti-NETs Therapeutics.
TL;DR: NETosis is described in different diseases focusing on the detrimental effect of NETs and possible therapeutics that can be used to mitigate netosis are outlined, thereby decreasing damage to patients.
Interleukin-23 mediates the intestinal response to microbial β-1,3-glucan and the development of spondyloarthritis pathology in SKG mice
Helen Benham,Linda Rehaume,Sumaira Z. Hasnain,Jared Velasco,Athan Baillet,Merja Ruutu,Kristine Kay Kikly,Ran Wang,Hsu-Wen Tseng,Gethin P. Thomas,Matthew A. Brown,Geoffrey Strutton,Michael A. McGuckin,Ranjeny Thomas +13 more
TL;DR: In this article, the location of IL-23 production and its role in spondyloarthritides (SpA) pathogenesis in BALB/c ZAP-70W163C-mutant (SKG) mice injected intraperitoneally with β-1,3-glucan (curdlan) was determined.
Journal ArticleDOI
Extraintestinal Manifestations of Inflammatory Bowel Disease: Current Concepts, Treatment, and Implications for Disease Management
TL;DR: A comprehensive overview of epidemiology, pathophysiology, clinical presentation, and treatment of extraintestinal manifestations (EIMs) in inflammatory bowel diseases can be found in this paper.
Journal ArticleDOI
Extraintestinal manifestations in inflammatory bowel disease - epidemiology, genetics, and pathogenesis.
TL;DR: It still remains unclear whether EIM is a direct result of the inflammatory process in the gut or rather a consequence of a shared genetic background leading to dysfunctional immune responses to environmental stimuli, and pathogenesis is at best partially understood.
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Intestinal Tolerance Requires Gut Homing and Expansion of FoxP3 + Regulatory T Cells in the Lamina P
Usriansyah Hadis,Benjamin Wahl,Olga Schulz,Matthias Hardtke-Wolenski,Angela Schippers,Norbert Wagner,Werner Müller,Tim Sparwasser,Reinhold Förster,Oliver Pabst +9 more
TL;DR: In this article, the authors use several mouse models to show that Treg cells, after their generation in lymph nodes, need to home to the gut to undergo local expansion to install oral tolerance.
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