The Prevalence of Symptoms in 24,410 Adults Infected by the Novel Coronavirus (SARS-CoV-2;COVID-19): A Systematic Review and Meta-Analysis of 148 Studies from 9 Countries
Michael C. Grant,Luke Geoghegan,Marc Arbyn,Zakaria Mohammed,Zakaria Mohammed,Luke A McGuinness,Emily L. Clarke,Ryckie G. Wade,Ryckie G. Wade +8 more
Reads0
Chats0
TLDR
It is confirmed that fever and cough are the most prevalent symptoms of adults infected by SARS-CoV-2, however, there is a large proportion of infected adults which symptoms-alone do not identify.Abstract:
Background To limit the spread of SARS-CoV-2, an evidence-based understanding of the symptoms is critical to inform guidelines for quarantining and testing. The most common features are purported to be fever and a new persistent cough, although the global prevalence of these symptoms remains unclear. The aim of this systematic review is to determine the prevalence of symptoms associated with COVID-19 worldwide. Methods We searched PubMed, Embase, CINAHL, AMED, medRxiv and bioRxiv on 5th April 2020 for studies of adults (>16 years) with laboratory test confirmed COVID-19. No language or publication status restrictions were applied. Data were independently extracted by two review authors into standardised forms. All datapoints were independently checked by three other review authors. A random-effects model for pooling of binomial data was applied to estimate the prevalence of symptoms, subgrouping estimates by country. I2 was used to assess inter-study heterogeneity. Results Of 851 unique citations, 148 articles were included which comprised 24,410 adults with confirmed COVID-19 from 9 countries. The most prevalent symptoms were fever (78% [95% CI 75%-81%]; 138 studies, 21,701 patients; I2 94%), a cough (57% [95% CI 54%-60%]; 138 studies, 21,682 patients; I2 94%) and fatigue (31% [95% CI 27%-35%]; 78 studies, 13,385 patients; I2 95%). Overall, 19% of hospitalised patients required non-invasive ventilation (44 studies, 6,513 patients), 17% required intensive care (33 studies, 7504 patients), 9% required invasive ventilation (45 studies, 6933 patients) and 2% required extra-corporeal membrane oxygenation (12 studies, 1,486 patients). The mortality rate was 7% (73 studies, 10,402 patients). Conclusions We confirm that fever and cough are the most prevalent symptoms of adults infected by SARS-CoV-2. However, there is a large proportion of infected adults which symptoms-alone do not identify.read more
Citations
More filters
Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
TL;DR: Prolonged viral shedding provides the rationale for a strategy of isolation of infected patients and optimal antiviral interventions in the future.
Posted Content
COVID-19 Generated Changes to Planning and Development Controls in South Australia (preprint)
TL;DR: Nearly 50% COVID-19 patients could not reach obvious clinical and radiological remission within 10 days after hospitalization, and the patients with male sex, anorexia and no fever on admission predicted poor efficacy.
Journal ArticleDOI
International consensus statement on allergy and rhinology: rhinosinusitis 2021
Richard R. Orlandi,Todd T. Kingdom,Timothy L. Smith,Benjamin S. Bleier,Adam S. DeConde,Amber U Luong,David M. Poetker,Zachary M. Soler,Kevin C. Welch,Sarah K. Wise,Nithin D. Adappa,Jeremiah A. Alt,Wilma Terezinha Anselmo-Lima,Claus Bachert,Claus Bachert,Claus Bachert,Fuad M. Baroody,Pete S. Batra,Manuel Bernal-Sprekelsen,Daniel M. Beswick,Neil Bhattacharyya,Rakesh K. Chandra,Eugene H. Chang,Alexander G. Chiu,Naweed I. Chowdhury,Martin J. Citardi,Noam A. Cohen,David B. Conley,John M. DelGaudio,Martin Desrosiers,Richard G. Douglas,Jean Anderson Eloy,Wytske Fokkens,Stacey T. Gray,David A. Gudis,Daniel L. Hamilos,Joseph K. Han,Richard J. Harvey,Peter Hellings,Eric H. Holbrook,Claire Hopkins,Peter H. Hwang,Amin R. Javer,Rong San Jiang,David N. Kennedy,Robert C. Kern,Tanya M. Laidlaw,Devyani Lal,Andrew P. Lane,Heung Man Lee,Jivianne T. Lee,Joshua M. Levy,Sandra Y. Lin,Valerie J. Lund,Kevin C. McMains,Ralph Metson,Joaquim Mullol,Robert M. Naclerio,Gretchen M. Oakley,Nobuyoshi Otori,James N. Palmer,Sanjay R. Parikh,Desiderio Passali,Zara M. Patel,Anju T. Peters,Carl Philpott,Alkis J. Psaltis,Vijay R. Ramakrishnan,Murugappan Ramanathan,Hwan Jung Roh,Luke Rudmik,Raymond Sacks,Rodney J. Schlosser,Ahmad R. Sedaghat,Brent A. Senior,Raj Sindwani,Kristine A. Smith,Kornkiat Snidvongs,Michael G. Stewart,Jeffrey D. Suh,Bruce K. Tan,Justin H. Turner,Cornelis M. van Drunen,Richard Louis Voegels,De Yun Wang,Bradford A. Woodworth,Peter-John Wormald,Erin D. Wright,Carol H. Yan,Luo Zhang,Bing Zhou +90 more
TL;DR: The 5 years since the publication of the first International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed foundational progress in the understanding and treatment of rhinologic disease.
Journal ArticleDOI
Post-COVID-19 syndrome among symptomatic COVID-19 patients: A prospective cohort study in a tertiary care center of Bangladesh.
Reaz Mahmud,Mujibur Rahman,Mohammad Aftab Rassel,Farhana Binte Monayem,S. K. Jakaria Been Sayeed,Shahidul Islam,Mohammed Monirul Islam +6 more
TL;DR: In this paper, the authors conducted a prospective cohort study to determine the incidence, association, and risk factors associated with development of the post-coronavirus disease (COVID-19) syndrome.
Journal ArticleDOI
Anosmia in COVID-19: Underlying Mechanisms and Assessment of an Olfactory Route to Brain Infection.
TL;DR: Current evidence is critically examined whether and how the SARS-CoV-2 virus can follow a route from the olfactory epithelium in the nose to the brain to achieve brain infection and the prospects for using the smell and taste dysfunctions seen in COVID-19 as an early and rapid diagnostic screening tool are discussed.
References
More filters
Journal ArticleDOI
The different clinical characteristics of corona virus disease cases between children and their families in China - the character of children with COVID-19.
Liang Su,Xiang Ma,Huafeng Yu,Zhaohua Zhang,Pengfei Bian,Yuling Han,Jing Sun,Yanqin Liu,Chun Yang,Jin Geng,Zhongfa Zhang,Zhongtao Gai +11 more
TL;DR: COVID-19 in children is mainly caused by family transmission, and their symptoms are mild and prognosis is better than adult, however, their PCR result in stool showed longer time than their families, which is difficult to recognize early for pediatrician and public health staff.
Journal ArticleDOI
Maternal and Neonatal Outcomes of Pregnant Women With Coronavirus Disease 2019 (COVID-19) Pneumonia: A Case-Control Study.
Na Li,Lefei Han,Min Peng,Yuxia Lv,Yin Ouyang,Kui Liu,Linli Yue,Qiannan Li,Guoqiang Sun,Lin Chen,Lin Yang +10 more
TL;DR: Severe maternal and neonatal complications were not observed in pregnant women with COVID-19 pneumonia who had vaginal delivery or caesarean section and the need of effective screening on admission is highlighted.
Journal ArticleDOI
Analysis of Epidemiological and Clinical Features in Older Patients With Coronavirus Disease 2019 (COVID-19) Outside Wuhan.
Jiangshan Lian,Xi Jin,Shaorui Hao,Huan Cai,Shanyan Zhang,Lin Zheng,Hongyu Jia,Jianhua Hu,Jianguo Gao,Yimin Zhang,Xiaoli Zhang,Guodong Yu,Xiaoyan Wang,Jueqing Gu,Chanyuan Ye,Ciliang Jin,Yingfeng Lu,Xia Yu,Xiaopeng Yu,Yue Ren,Yunqing Qiu,Lanjuan Li,Jifang Sheng,Yida Yang +23 more
TL;DR: The specific epidemiological and clinical features of older COVID-19 patients included significantly higher female gender, body temperature, co-existing of basic diseases and rate of severe and critical type.
Journal ArticleDOI
Eleven faces of coronavirus disease 2019.
Xiang Dong,Yi yuan Cao,Xiao xia Lu,Jin jin Zhang,Hui Du,You qin Yan,Cezmi A. Akdis,Ya dong Gao +7 more
TL;DR: The various clinical presentations of this disease are described by examining eleven cases of SARS‐CoV‐2 infection by examiningEleven cases of coronavirus disease 2019 are examined.
Journal ArticleDOI
Don't Overlook Digestive Symptoms in Patients With 2019 Novel Coronavirus Disease (COVID-19).
TL;DR: This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record.
Related Papers (5)
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
Clinical Characteristics of Coronavirus Disease 2019 in China.
Wei-jie Guan,Zhengyi Ni,Yu Hu,Wenhua Liang,Chun-Quan Ou,Jianxing He,Lei Liu,Hong Shan,Chunliang Lei,David S.C. Hui,Bin Du,Lanjuan Li,Guang Zeng,Kowk-Yung Yuen,Ruchong Chen,Chun-Li Tang,Tao Wang,Ping-Yan Chen,Jie Xiang,Shiyue Li,Jinlin Wang,Zi-jing Liang,Yi-xiang Peng,Li Wei,Yong Liu,Ya-hua Hu,Peng Peng,Jian-ming Wang,Ji-yang Liu,Zhong Chen,Gang Li,Zhi-jian Zheng,Shao-qin Qiu,Jie Luo,Chang-jiang Ye,Shao-yong Zhu,Nanshan Zhong +36 more
Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention
Zunyou Wu,Jennifer M. McGoogan +1 more