The Promise of Targeting Macrophages in Cancer Therapy
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TLDR
The data clearly support the validity of clinical testing of combining targeting TAMs with conventional therapy and the many preclinical studies that have shown that the response of tumors to irradiation and anticancer drugs can be improved, sometimes markedly so, by depleting TAMs from tumors or by suppressing their polarization from an M1 to an M2 phenotype.Abstract:
Cancer therapy has developed around the concept of killing, or stopping the growth of, the cancer cells. Molecularly targeted therapy is the modern expression of this paradigm. Increasingly, however, the realization that the cancer has co-opted the normal cells of the stroma for its own survival has led to the concept that the tumor microenvironment (TME) could be targeted for effective therapy. In this Review we outline the importance of tumor associated macrophages (TAMs), a major component of the TME, in the response of tumors to cancer therapy. We discuss the normal role of macrophages in wound healing, the major phenotypes of TAMs and their role in blunting the efficacy to cancer treatment by radiation and anticancer drugs both by promoting tumor angiogenesis and by suppressing antitumor immunity. Finally we review the many preclinical studies that have shown that the response of tumors to irradiation and anticancer drugs can be improved, sometimes markedly so, by depleting TAMs from tumors or by suppressing their polarization from an M1 to an M2 phenotype. The data clearly support the validity of clinical testing of combining targeting TAMs with conventional therapy.read more
Citations
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Polarization of tumor-associated macrophage phenotype via porous hollow iron nanoparticles for tumor immunotherapy in vivo.
Ke Li,Lu Lu,Chencheng Xue,Ju Liu,Ye He,Jun Zhou,Zengzilu Xia,Liangliang Dai,Zhong Luo,Yulan Mao,Kaiyong Cai +10 more
TL;DR: The study provides an intracellular switch of the TAM phenotype for targeted TAM therapy and synergistically switched TAMs to pro-inflammatory M1-type macrophages.
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Distant Relations: Macrophage Functions in the Metastatic Niche
TL;DR: Macrophage functions in establishing distant metastases including formation of the premetastatic niche, extravasation of circulating cancer cells, and colonization of secondary metastases are discussed.
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Tumour-associated macrophages are associated with poor prognosis and programmed death ligand 1 expression in oesophageal cancer.
Taisuke Yagi,Yoshifumi Baba,Kazuo Okadome,Yuki Kiyozumi,Yukiharu Hiyoshi,Takatsugu Ishimoto,Masaaki Iwatsuki,Yuji Miyamoto,Naoya Yoshida,Masayuki Watanabe,Yoshihiro Komohara,Hideo Baba +11 more
TL;DR: High TAM density in oesophageal cancer tissues was associated with shorter survival, suggesting a prognostic biomarker role for TAMs, and the current findings should have considerable clinical implications.
Journal ArticleDOI
CD47 blockade augmentation of trastuzumab antitumor efficacy dependent on antibody-dependent cellular phagocytosis
Li-Chung Tsao,Erika J. Crosby,Timothy N. Trotter,Pankaj K. Agarwal,Bin-Jin Hwang,Chaitanya R. Acharya,Casey W. Shuptrine,Tao Wang,Junping Wei,Xiao Yang,Gangjun Lei,Cong-Xiao Liu,Christopher A. Rabiola,Lewis A. Chodosh,William J. Muller,Herbert Kim Lyerly,Zachary C. Hartman +16 more
TL;DR: Trastuzumab-mediated ADCP is identified as a significant antitumor MOA that may be clinically enabled by CD47 blockade to augment therapeutic efficacy and emergence of a unique hyper-phagocytic macrophage population.
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RACK1 promotes cancer progression by increasing the M2/M1 macrophage ratio via the NF-κB pathway in oral squamous cell carcinoma.
Hongxia Dan,Sai Liu,Sai Liu,Jiajia Liu,Dongjuan Liu,Dongjuan Liu,Fengying Yin,Zihao Wei,Jiongke Wang,Yu Zhou,Lu Jiang,Ning Ji,Xin Zeng,Jing Li,Qianming Chen +14 more
TL;DR: Results indicate that RACK1 and the M2/M1 ratio are predictors of a poor prognosis in OSCC and could be used as a potential therapeutic target for antitumor immunity.
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