The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice
Elizabeth C. Townsend,Mark A. Murakami,Alexandra N. Christodoulou,Amanda L. Christie,Johannes Köster,Tiffany DeSouza,Elizabeth A. Morgan,Scott P. Kallgren,Huiyun Liu,Shuo-Chieh Wu,Olivia Plana,Joan Montero,Kristen E. Stevenson,Prakash Rao,Raga Vadhi,Michael Andreeff,Philippe Armand,Karen K. Ballen,Patrizia Barzaghi-Rinaudo,Sarah Cahill,Rachael A. Clark,Vesselina G. Cooke,Matthew S. Davids,Daniel J. DeAngelo,David M. Dorfman,Hilary Eaton,Benjamin L. Ebert,Julia Etchin,Brant Firestone,David C. Fisher,Arnold S. Freedman,Ilene Galinsky,Hui Gao,Jacqueline S. Garcia,Francine Garnache-Ottou,Timothy A. Graubert,Alejandro Gutierrez,Alejandro Gutierrez,Ensar Halilovic,Marian H. Harris,Zachary T. Herbert,Steven M. Horwitz,Giorgio Inghirami,Andrew M. Intlekofer,Moriko Ito,Shai Izraeli,Eric D. Jacobsen,Caron A. Jacobson,Sébastien Jeay,Irmela Jeremias,Michelle A. Kelliher,Raphael Koch,Marina Konopleva,Nadja Kopp,Steven M. Kornblau,Andrew L. Kung,Thomas S. Kupper,Nicole R. LeBoeuf,Ann S. LaCasce,Emma Lees,Loretta S. Li,A. Thomas Look,Masato Murakami,Markus Müschen,Donna Neuberg,Samuel Y. Ng,Oreofe O. Odejide,Stuart H. Orkin,Rachel R. Paquette,Andrew E. Place,Justine E. Roderick,Jeremy Ryan,Stephen E. Sallan,Brent Shoji,Lewis B. Silverman,Robert J. Soiffer,David P. Steensma,Kimberly Stegmaier,Richard Stone,Jerome Tamburini,Aaron R. Thorner,Paul Van Hummelen,Martha Wadleigh,Marion Wiesmann,Andrew P. Weng,Jens Wuerthner,David A. Williams,Bruce M. Wollison,Andrew A. Lane,Anthony Letai,Monica M. Bertagnolli,Jerome Ritz,Myles Brown,Henry W. Long,Jon C. Aster,Margaret A. Shipp,James D. Griffin,David M. Weinstock,David M. Weinstock +98 more
TLDR
It is demonstrated that large studies of acute leukemia PDXs that mimic human randomized clinical trials can characterize drug efficacy and generate transcriptional, functional, and proteomic biomarkers in both treatment-naive and relapsed/refractory disease.About:
This article is published in Cancer Cell.The article was published on 2016-04-11 and is currently open access. It has received 261 citations till now.read more
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Biomarker-guided treatment strategies for ovarian cancer identified from a heterogeneous panel of patient-derived tumor xenografts
Adam C. Palmer,Adam C. Palmer,Deborah Plana,Deborah Plana,Hui Gao,Joshua M. Korn,Guizhi Yang,John Green,Xiamei Zhang,Roberto Velazquez,Margaret E. McLaughlin,David A. Ruddy,Colleen Kowal,Julie Goldovitz,Caroline Bullock,Stacy Rivera,Daniel P. Rakiec,GiNell Elliott,Paul Fordjour,Ronald Meyer,Alice Loo,Esther Kurth,Jeffrey A. Engelman,Hans Bitter,William R. Sellers,Peter K. Sorger,Juliet Williams +26 more
TL;DR: The PDX panel aimed to mimic the heterogeneity of disease observed in patients, and exhibited a distribution of responsiveness to standard of care chemotherapy similar to human clinical data, suggesting the possibility of a new therapeutic approach to ovarian cancer and demonstrating the potential power of PDX-based trials in broadening the reach of precision cancer medicine.
Journal ArticleDOI
Supramolecular assembly of GSK3α as a cellular response to amino acid starvation.
Laura Hinze,Sabine Schreek,Andre Zeug,N. K. Ibrahim,Beate Fehlhaber,L. Loxha,Buesra Cinar,Evgeni Ponimaskin,James Degar,Connor McGuckin,Gabriela Chiosis,Cornelia Eckert,Gunnar Cario,Beat Bornhauser,Jean-Pierre Bourquin,Martin Stanulla,Alejandro Landero Gutiérrez +16 more
TL;DR: The authors showed that resistance to asparagine starvation is uniquely dependent on an N-terminal low-complexity domain of GSK3α, which its paralog GSKβ lacks.
Journal ArticleDOI
A reliable method to determine which candidate chemotherapeutic drugs effectively inhibit tumor growth in patient-derived xenografts (PDX) in single mouse trials.
Derek Gordon,David E. Axelrod +1 more
TL;DR: A statistical method that can group anti-cancer drugs into those that are inhibitory and those that is non-inhibitory in single mouse trials and provide probabilities that the grouping is correct is reported on.
Journal ArticleDOI
Bone Marrow Microenvironment-Induced Chemoprotection in KMT2A Rearranged Pediatric AML Is Overcome by Azacitidine–Panobinostat Combination
TL;DR: In this article , the effect of epigenetic therapy on pediatric acute myeloid leukemia (AML) cells in multicell coculture and in murine models was tested and it was shown that epigenetic drug combination followed by chemotherapy was effective in overcoming chemoprotection.
Posted ContentDOI
Functional precision oncology for follicular lymphoma with patient-derived xenograft in avian embryos
Manon Zala,Boris Lipinski,Clélia Costechareyre,Loraine Jarrosson,Romain Teinturier,Edith Julia,Marjorie Lacourrège,Aurélie Verney,Jérôme Guitton,Alexandra Traverse-Glehen,Emmanuel Bachy,Gilles Salles,Sarah Huet,Laurent Genestier,Valérie Castellani,Céline Delloye-Bourgeois,Pierre Sujobert +16 more
TL;DR: The FL-AVI-PDX model is a platform for functional precision oncology in primary Follicular lymphoma (FL) cells that captures both inter-and intra-patient heterogeneity of clinical response to a complex therapeutic regimen as discussed by the authors .
References
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limma powers differential expression analyses for RNA-sequencing and microarray studies
Matthew E. Ritchie,Belinda Phipson,Di Wu,Yifang Hu,Charity W. Law,Wei Shi,Gordon K. Smyth,Gordon K. Smyth +7 more
TL;DR: The philosophy and design of the limma package is reviewed, summarizing both new and historical features, with an emphasis on recent enhancements and features that have not been previously described.
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The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
Jordi Barretina,Giordano Caponigro,Nicolas Stransky,Kavitha Venkatesan,Adam A. Margolin,Adam A. Margolin,Sungjoon Kim,Christine D. Wilson,Joseph Lehar,Gregory V. Kryukov,Dmitriy Sonkin,Anupama Reddy,Manway Liu,Lauren Murray,Michael F. Berger,Michael F. Berger,John Monahan,Paula Morais,Jodi Meltzer,Adam Korejwa,Judit Jané-Valbuena,Judit Jané-Valbuena,Felipa A. Mapa,Joseph Thibault,Eva Bric-Furlong,Pichai Raman,Aaron Shipway,Ingo H. Engels,Jill Cheng,Guoying K. Yu,Jianjun Yu,Peter Aspesi,Melanie de Silva,Kalpana Jagtap,Michael D. Jones,Li Wang,Charlie Hatton,Emanuele Palescandolo,Supriya Gupta,Scott Mahan,Carrie Sougnez,Robert C. Onofrio,Ted Liefeld,Laura E. MacConaill,Wendy Winckler,Michael R. Reich,Nanxin Li,Jill P. Mesirov,Stacey Gabriel,Gad Getz,Kristin G. Ardlie,Vivien W. Chan,Vic E. Myer,Barbara L. Weber,Jeffrey A. Porter,Markus Warmuth,Peter Finan,Jennifer L. Harris,Matthew Meyerson,Matthew Meyerson,Todd R. Golub,Michael Morrissey,William R. Sellers,Robert Schlegel,Levi A. Garraway,Levi A. Garraway +65 more
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Can the pharmaceutical industry reduce attrition rates
Ismail Kola,John Landis +1 more
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Snakemake--a scalable bioinformatics workflow engine.
Johannes Köster,Sven Rahmann +1 more
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Transcriptional control of human p53-regulated genes
TL;DR: The most comprehensive list so far of human p53-regulated genes and their experimentally validated, functional binding sites that confer p53 regulation is presented.
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