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Open AccessJournal ArticleDOI

The Reciprocal Interactions between Polyphenols and Gut Microbiota and Effects on Bioaccessibility

TLDR
This review focuses on the biotransformation of polyphenols by gut microbiota, modulation of gut microbiota bypolyphenols, and the effects of these two-way mutual interactions on polyphenol bioavailability, and ultimately, human health.
Abstract
As of late, polyphenols have increasingly interested the scientific community due to their proposed health benefits. Much of this attention has focused on their bioavailability. Polyphenol–gut microbiota interactions should be considered to understand their biological functions. The dichotomy between the biotransformation of polyphenols into their metabolites by gut microbiota and the modulation of gut microbiota composition by polyphenols contributes to positive health outcomes. Although there are many studies on the in vivo bioavailability of polyphenols, the mutual relationship between polyphenols and gut microbiota is not fully understood. This review focuses on the biotransformation of polyphenols by gut microbiota, modulation of gut microbiota by polyphenols, and the effects of these two-way mutual interactions on polyphenol bioavailability, and ultimately, human health.

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Journal ArticleDOI

Role of the gut microbiota in nutrition and health

TL;DR: Ana M Valdes and colleagues discuss strategies for modulating the gut microbiota through diet and probiotics and suggest that a Mediterranean diet supplemented with probiotics can be a viable alternative to a probiotic regime.
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Macronutrient metabolism by the human gut microbiome: major fermentation by-products and their impact on host health

TL;DR: Current knowledge of how macronutrient metabolism by the gut microbiome influences human health is summarized and knowledge gaps that could contribute to the understanding of overall human wellness will be identified.
Journal ArticleDOI

The microbiota-gut-brain axis in obesity.

TL;DR: The gut microbiota is becoming a target for new anti-obesity therapies and the potential of gut-microbiota-targeted strategies, such as dietary interventions and faecal microbiota transplantation, as promising metabolic therapies that help patients to maintain a healthy weight throughout life are investigated.
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Natural polyphenols: An overview

TL;DR: In this paper, a plant-derived functional foods are gaining considerable attention due to their safety and therapeutic potentials, however, research on plant-based functional foods presents several challenges ranges from hy...
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The Effects of Vegetarian and Vegan Diets on Gut Microbiota.

TL;DR: The available literature suggests that a vegetarian/vegan diet is effective in promoting a diverse ecosystem of beneficial bacteria to support both human gut microbiome and overall health.
References
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Journal ArticleDOI

Polyphenols: food sources and bioavailability

TL;DR: The nature and contents of the various polyphenols present in food sources and the influence of agricultural practices and industrial processes are reviewed, and bioavailability appears to differ greatly between the variousPolyphenols, and the most abundantpolyphenols in the authors' diet are not necessarily those that have the best bioavailability profile.
Journal ArticleDOI

Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies

TL;DR: Gallic acid and isoflavones are the most well-absorbed polyphenols, followed by catechins, flavanones, and quercetin glucosides, but with different kinetics, and the least well- absorption polyphenol are the proanthocyanidins, the galloylated tea catech ins, andThe anthocyanins.
Journal ArticleDOI

Functional interactions between the gut microbiota and host metabolism

TL;DR: Through increased knowledge of the mechanisms involved in the interactions between the microbiota and its host, the world will be in a better position to develop treatments for metabolic disease.
Journal ArticleDOI

Dietary Intake and Bioavailability of Polyphenols

TL;DR: Both chemical and biochemical factors that affect the absorption and metabolism of polyphenols are reviewed, with particular emphasis on flavonoid glycosides.
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