Journal ArticleDOI
The World of Dementia Beyond 2020
Henry Brodaty,Monique M.B. Breteler,Steven T. DeKosky,Pascale Dorenlot,Laura Fratiglioni,Christoph Hock,Paul‐Ariel Kenigsberg,Philip Scheltens,Bart De Strooper,Bart De Strooper +9 more
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TLDR
An overview of current achievements and potentials of basic and clinical research that might affect the development of dementia prevalence and care within the near future is provided.Abstract:
Counterpoised against dire projections of the tripling of the prevalence of dementia over the next 40 years are major developments in diagnostic biomarkers, neuroimaging, the molecular biology of Alzheimer's disease (AD), epidemiology of risk and protective factors, and drug treatments-mainly targeting the amyloid pathway, tau protein, and immunotherapy-that may have the potential to modify the progression of AD. Drug combinations and presymptomatic treatments are also being investigated. Previous trials of dementia-modifying drugs have not shown benefit, and even if current Phase III trials prove successful, these drugs will not eradicate other dementias, could (if not curative) increase dementia duration and prevalence, and are unlikely to come onto the market before 2020. In the meantime, delaying the onset of dementia by even 2 years would have significant economic and societal effects. This article provides an overview of current achievements and potentials of basic and clinical research that might affect the development of dementia prevalence and care within the near future.read more
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Journal ArticleDOI
Defeating Alzheimer's disease and other dementias: a priority for European science and society
Bengt Winblad,Bengt Winblad,Philippe Amouyel,Sandrine Andrieu,Clive Ballard,Carol Brayne,Henry Brodaty,Angel Cedazo-Minguez,Bruno Dubois,David Edvardsson,David Edvardsson,Howard Feldman,Laura Fratiglioni,Giovanni B. Frisoni,Serge Gauthier,Jean Georges,Caroline Graff,Caroline Graff,Khalid Iqbal,Frank Jessen,Frank Jessen,Gunilla Johansson,Linus Jönsson,Miia Kivipelto,Miia Kivipelto,Martin Knapp,Francesca Mangialasche,René J. F. Melis,Agneta Nordberg,Agneta Nordberg,Marcel G. M. Olde Rikkert,Chengxuan Qiu,Thomas P. Sakmar,Thomas P. Sakmar,Philip Scheltens,Lon S. Schneider,Reisa A. Sperling,Lars O. Tjernberg,Gunhild Waldemar,Anders Wimo,Henrik Zetterberg,Henrik Zetterberg +41 more
TL;DR: This poster aims to demonstrate the efforts towards in-situ applicability of EMMARM, which aims to provide real-time information about the physical and cognitive properties of Alzheimer's disease and other dementias.
Journal ArticleDOI
Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer's disease.
TL;DR: Recent advances are discussed that have illuminated the chemical nature of the toxic species and the deleterious impact they have on synapses, and have culminated in the proposal of an Aβ oligomer hypothesis for Alzheimer’s pathogenesis.
Journal ArticleDOI
The Multidisciplinary Approach to Alzheimer's Disease and Dementia. A Narrative Review of Non-Pharmacological Treatment
Chiara Zucchella,Elena Sinforiani,Stefano Tamburin,Angela Federico,Elisa Mantovani,Sara Bernini,Roberto Casale,Michelangelo Bartolo +7 more
TL;DR: Although NPT is often applied in the multidisciplinary approach to AD and dementia, supporting evidence for their use is still preliminary and well-designed randomized controlled trials with innovative designs are needed to explore the efficacy of NPT inAD and dementia.
Journal ArticleDOI
Education and Risk of Dementia: Dose-Response Meta-Analysis of Prospective Cohort Studies.
Wei Xu,Lan Tan,Lan Tan,Hui-Fu Wang,Meng-Shan Tan,Lin Tan,Jie-Qiong Li,Qing-Fei Zhao,Jin-Tai Yu,Jin-Tai Yu +9 more
TL;DR: Both low and high education showed a trend of dose-response relation with risk of dementia and AD, and the dementia risk was reduced by 7 % for per year increase in education.
Journal ArticleDOI
Alzheimer's disease, enzyme targets and drug discovery struggles: from natural products to drug prototypes.
TL;DR: The state-of-the-art of the development of recent enzymatic inhibitors and enhancers with therapeutic potential on the treatment of AD are described.
References
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Journal ArticleDOI
Global prevalence of dementia: a Delphi consensus study
Cleusa P. Ferri,Martin Prince,Carol Brayne,Henry Brodaty,Laura Fratiglioni,Mary Ganguli,Kathleen S. Hall,Kazuo Hasegawa,Hugh C. Hendrie,Yueqin Huang,Anthony F. Jorm,Colin Mathers,Paulo Rossi Menezes,Elizabeth Rimmer,Marcia Scazufca +14 more
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Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS–ADRDA criteria
Bruno Dubois,Howard Feldman,Claudia Jacova,Steven T. DeKosky,Pascale Barberger-Gateau,Jeffrey L. Cummings,André Delacourte,Douglas Galasko,Serge Gauthier,Gregory A. Jicha,Kenichi Meguro,John T. O'Brien,Florence Pasquier,Philippe Robert,Martin N. Rossor,Steven Salloway,Yaakov Stern,Pieter Jelle Visser,Philip Scheltens +18 more
TL;DR: The NINCDS-ADRDA and DSM-IV-TR criteria for Alzheimer's disease (AD) are the prevailing diagnostic standards in research; however, they have now fallen behind the unprecedented growth of scientific knowledge as discussed by the authors.
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Alzheimer's Disease Is a Synaptic Failure
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An active and socially integrated lifestyle in late life might protect against dementia.
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