There's more to death than life: Noncatalytic functions in kinase and pseudokinase signaling.
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TLDR
A review of the non-catalytic functions of protein kinases can be found in this paper, where the authors consider pseudokinases, proteins that are devoid of enzymatic activity altogether and demonstrate that, beyond conventional notions of kinase function, catalytic activity can be dispensable for biological function.About:
This article is published in Journal of Biological Chemistry.The article was published on 2021-01-01 and is currently open access. It has received 40 citations till now. The article focuses on the topics: Kinase activity & Protein kinase A.read more
Citations
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Journal ArticleDOI
Targeting the Non-Catalytic Functions: a New Paradigm for Kinase Drug Discovery?
TL;DR: The characterized noncatalytic functions of kinases are summarized, and the recent progress on developing small-molecule modulators of the noncatalyst functions of Kinase catalytic functions are highlighted.
Journal ArticleDOI
Blocking Non-enzymatic Functions by PROTAC-Mediated Targeted Protein Degradation.
TL;DR: In this paper , the authors summarize and analyze recent progress in blocking non-enzymatic functions of target proteins by PROTAC-mediated degradation, highlighting representative case studies and discussing the pharmacological features originating from inhibition of the non enzymatic function.
Journal ArticleDOI
Chemical Probes for Understudied Kinases: Challenges and Opportunities.
Ricardo A. M. Serafim,Jonathan M. Elkins,William J. Zuercher,Stefan Laufer,Matthias Gehringer +4 more
TL;DR: In this paper, the authors highlight recent case studies illustrating the development of high-quality chemical probes for less-studied kinases and their application in target validation and discuss the associated challenges and opportunities.
Journal ArticleDOI
Looking lively: emerging principles of pseudokinase signaling.
Joshua B. Sheetz,Mark A. Lemmon +1 more
TL;DR: In this paper , the authors discuss recent structural data on conformational transitions and nucleotide binding by pseudokinases and discuss how biasing this conformational toggle may provide opportunities to target pseudokinase pharmacologically in disease.
Journal ArticleDOI
Structure vs. Function of TRIB1—Myeloid Neoplasms and Beyond
TL;DR: The TRIB1 family of proteins as discussed by the authors plays important roles in differentiation, development, and oncogenesis, and is known to be accessible to small-molecule inhibitors in spite of its inability to bind ATP.
References
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Journal ArticleDOI
Protein AMPylation by an Evolutionarily Conserved Pseudokinase.
Anju Sreelatha,Samantha S. Yee,Victor Lopez,Brenden C. Park,Lisa N. Kinch,Sylwia Pilch,Kelly A. Servage,Junmei Zhang,Jenny Jiou,Monika Karasiewicz-Urbańska,Małgorzata Łobocka,Nick V. Grishin,Kim Orth,Roza Kucharczyk,Krzysztof Pawłowski,Diana R. Tomchick,Vincent S. Tagliabracci +16 more
TL;DR: It is shown that the highly conserved pseudokinase selenoprotein-O (SelO) transfers AMP from ATP to Ser, Thr, and Tyr residues on protein substrates (AMPylation), uncovering a previously unrecognized activity for a member of the protein kinase superfamily.
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Eukaryotic-like protein kinases in the prokaryotes and the myxobacterial kinome
TL;DR: This analysis of 626 prokaryotic genomes reveals that eukaryotic-like protein kinases (ELKs) are found in nearly two-thirds of the sequenced strains, an observation that suggests that this group exploits sophisticated and novel signal transduction systems.
Journal ArticleDOI
Dimeric Structure of Pseudokinase RNase L Bound to 2-5A Reveals a Basis for Interferon-Induced Antiviral Activity
Hao Huang,Elton Zeqiraj,Beihua Dong,Babal K. Jha,Nicole M. Duffy,Stephen Orlicky,Neroshan Thevakumaran,Neroshan Thevakumaran,Manisha Talukdar,Manisha Talukdar,Monica C. Pillon,Derek F. Ceccarelli,Leo C. K. Wan,Leo C. K. Wan,Yu-Chi Juang,Daniel Y.L. Mao,Christina Gaughan,Margo A. Brinton,Andrey A. Perelygin,Igor Kourinov,Alba Guarné,Robert H. Silverman,Frank Sicheri,Frank Sicheri +23 more
TL;DR: These studies reveal how recognition of 2-5A through interactions with the ankyrin repeat domain and the pseudokinase domain, together with nucleotide binding, imposes a rigid intertwined dimer configuration that is essential for RNase catalytic and antiviral functions.
Journal ArticleDOI
Strong anion exchange-mediated phosphoproteomics reveals extensive human non-canonical phosphorylation
Gemma Hardman,Simon Perkins,Philip Brownridge,Christopher J Clarke,Dominic P. Byrne,Alan Campbell,Anton Kalyuzhnyy,Ashleigh C. Myall,Patrick A. Eyers,Andrew R. Jones,Claire E. Eyers +10 more
TL;DR: An unbiased phosphopeptide enrichment strategy based on strong anion exchange (SAX) chromatography (UPAX), which permits identification of histidine (His), arginine (Arg), lysine (Lys), aspartate (Asp), glutamate (Glu) and cysteine (Cys) phosphorylation sites on human proteins by mass spectrometry‐based phosphoproteomics is reported.
Journal ArticleDOI
A spatially resolved brain region- and cell type-specific isoform atlas of the postnatal mouse brain
Anoushka Joglekar,Andrey D. Prjibelski,Ahmed Mahfouz,Ahmed Mahfouz,Paul Collier,Susan Lin,Anna Katharina Schlusche,Jordan Marrocco,Stephen R. Williams,Bettina Haase,Ashley Hayes,Jennifer Chew,Neil I. Weisenfeld,Man Ying Wong,Alexander N. Stein,Simon A. Hardwick,Simon A. Hardwick,Toby Hunt,Qi Wang,Christoph Dieterich,Zachary Bent,Olivier Fedrigo,Steven A. Sloan,Davide Risso,Erich D. Jarvis,Erich D. Jarvis,Paul Flicek,Wenjie Luo,Geoffrey S. Pitt,Adam Frankish,August B. Smit,M. Elizabeth Ross,Hagen Tilgner +32 more
TL;DR: In this article, a single-cell investigation of differential isoform expression (DIE) between brain regions using singlecell long-read sequencing in mouse hippocampus and prefrontal cortex in 45 cell types at postnatal day 7 is presented.
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