TORCs: transducers of regulated CREB activity.
Michael D. Conkright,Gianluca Canettieri,Robert A. Screaton,Ernesto Guzman,Loren Miraglia,John B. Hogenesch,Marc Montminy +6 more
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TLDR
A conserved family of coactivators, designated TORCs, for Transducers of Regulated CREB activity, that enhances CRE-dependent transcription via a phosphorylation-independent interaction with the bZIP DNA binding/dimerization domain of CREB is characterized.About:
This article is published in Molecular Cell.The article was published on 2003-08-01 and is currently open access. It has received 569 citations till now. The article focuses on the topics: ATF/CREB & CRTC2.read more
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Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues
Xinmin Zhang,Duncan T. Odom,Seung Hoi Koo,Michael D. Conkright,Gianluca Canettieri,Jennifer L. Best,Huaming Chen,Richard G. Jenner,Elizabeth Herbolsheimer,Elisabeth Jacobsen,Shilpa Kadam,Joseph R. Ecker,Beverly M. Emerson,John B. Hogenesch,Terry G. Unterman,Richard A. Young,Marc Montminy +16 more
TL;DR: The results indicate that CREB phosphorylation alone is not a reliable predictor of target gene activation and that additional CREB regulatory partners are required for recruitment of the transcriptional apparatus to the promoter.
Journal ArticleDOI
The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism
Seung Hoi Koo,Lawrence Flechner,Ling Qi,Xinmin Zhang,Robert A. Screaton,Shawn Jeffries,Susan Hedrick,Wu Xu,Fayçal Boussouar,Paul K. Brindle,Hiroshi Takemori,Marc Montminy +11 more
TL;DR: It is shown that hormonal and energy-sensing pathways converge on the coactivator TORC2 (transducer of regulated CREB activity 2) to modulate glucose output and compounds that enhanceTORC2 phosphorylation may offer therapeutic benefits in this setting.
Journal ArticleDOI
Notch signaling: simplicity in design, versatility in function
TL;DR: Recent studies in nematodes, Drosophila and vertebrate systems that begin to shed light on how versatility in Notch signaling output is generated, how signal strength is modulated, and how cross-talk between the Notch pathway and other intracellular signaling systems, such as the Wnt, hypoxia and BMP pathways, contributes to signaling diversity.
Journal ArticleDOI
CREB and the CRTC co-activators: sensors for hormonal and metabolic signals.
TL;DR: A dual requirement for CREB phosphorylation and CRTC dephosphorylation is likely to explain how these activator–co-activator cognates discriminate between different stimuli.
Journal ArticleDOI
A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis
Ngan Vo,Matthew E. Klein,Matthew E. Klein,Olga Varlamova,David M. Keller,Tadashi Yamamoto,Richard H. Goodman,Soren Impey +7 more
TL;DR: Evidence is provided that miR132 regulates neuronal morphogenesis by decreasing levels of the GTPase-activating protein, p250GAP, which reveals that a CREB-regulated miRNA regulates neuronal Morphogenesis by responding to extrinsic trophic cues.
References
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Journal ArticleDOI
Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133
TL;DR: Results suggest that phosphorylation of CREB may stimulate transcription by a mechanism other than by simply providing negative charge, as CREB mutants containing acidic residues in place of the Ser-133 phosphoacceptor were also transcriptionally inactive.
Journal ArticleDOI
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Robert L. Strausberg,Elise A. Feingold,Lynette H. Grouse,Jeffery G. Derge,Richard D. Klausner,Francis S. Collins,Lukas Wagner,Carolyn M. Shenmen,Gregory D. Schuler,Stephen F. Altschul,Barry R. Zeeberg,Kenneth H. Buetow,Carl F. Schaefer,Narayan K. Bhat,Ralph F. Hopkins,Heather Jordan,Troy Moore,Steve I Max,Jun Wang,Florence Hsieh,Luda Diatchenko,Kate Marusina,Andrew A Farmer,Gerald M. Rubin,Ling Hong,Mark Stapleton,M. Bento Soares,Maria de Fatima Bonaldo,Thomas L. Casavant,Todd E. Scheetz,Michael J. Brownstein,Ted B. Usdin,Shiraki Toshiyuki,Piero Carninci,Christa Prange,Sam S Raha,Naomi A Loquellano,Garrick J Peters,Rick D Abramson,Sara J Mullahy,Stephanie Bosak,Paul J. McEwan,Kevin McKernan,Joel A. Malek,Preethi H. Gunaratne,Stephen Richards,Kim C. Worley,Sarah Hale,Angela M. Garcia,Stephen W. Hulyk,Debbie K Villalon,Donna M. Muzny,Erica Sodergren,Xiuhua Lu,Richard A. Gibbs,Jessica Fahey,Erin Helton,Mark Ketteman,Anuradha Madan,Stephanie Rodrigues,Amy Sanchez,Michelle Whiting,Anup Madan,Alice C. Young,Yuriy O. Shevchenko,Gerard G. Bouffard,Robert W. Blakesley,Jeffrey W. Touchman,Eric D. Green,Mark Dickson,Alex Rodriguez,Jane Grimwood,Jeremy Schmutz,Richard M. Myers,Yaron S.N. Butterfield,Martin Krzywinski,Ursula Skalska,Duane E. Smailus,Angelique Schnerch,Jacqueline E. Schein,Steven J.M. Jones,Marco A. Marra +81 more
TL;DR: The National Institutes of Health Mammalian Gene Collection (MGC) Program is a multiinstitutional effort to identify and sequence a cDNA clone containing a complete ORF for each human and mouse gene.
Journal ArticleDOI
Phosphorylated CREB binds specifically to the nuclear protein CBP
John C. Chrivia,Roland P. S. Kwok,Ned J.C. Lamb,Masatoshi Hagiwara,Marc Montminy,Richard H. Goodman +5 more
TL;DR: It is proposed that CBP may participate in cAMP-regulated gene expression by interacting with the activated phosphorylated form of CREB, which is activated as a result of phosphorylation by protein kinase A7.
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A DNA Vector-Based RNAi Technology to Suppress Gene Expression in Mammalian Cells
TL;DR: This work reports a technology that allows synthesis of small interfering RNAs from DNA templates in vivo to efficiently inhibit endogenous gene expression and demonstrates robust inhibition of several endogenous genes of diverse functions in mammalian cells.
Journal ArticleDOI
The regulation of transcription by phosphorylation
Tony Hunter,Michael Karin +1 more
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