Journal ArticleDOI
TOX promotes the exhaustion of antitumor CD8+ T cells by preventing PD1 degradation in hepatocellular carcinoma.
Xiaochen Wang,Qifeng He,Qifeng He,Haiyuan Shen,Anliang Xia,Anliang Xia,Wenfang Tian,Weiwei Yu,Beicheng Sun,Beicheng Sun +9 more
TLDR
Downregulating TOX expression improves the antitumor function of CD8+ T cells, which shows synergetic role with anti-PD1 therapy, highlighting a promising strategy for enhancement of cancer immunotherapy.About:
This article is published in Journal of Hepatology.The article was published on 2019-10-01. It has received 175 citations till now. The article focuses on the topics: T cell & Cytotoxic T cell.read more
Citations
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Journal ArticleDOI
Defining ‘T cell exhaustion’
Christian U. Blank,W. Nicholas Haining,Werner Held,Patrick G. Hogan,Patrick G. Hogan,Axel Kallies,Enrico Lugli,Rachel C. Lynn,Mary Philip,Anjana Rao,Anjana Rao,Nicholas P. Restifo,Andrea Schietinger,Ton N. Schumacher,Pamela L. Schwartzberg,Arlene H. Sharpe,Daniel E. Speiser,E. John Wherry,Benjamin Youngblood,Dietmar Zehn +19 more
TL;DR: In this Viewpoint article, 18 experts in the field tell us what exhaustion means to them, ranging from complete lack of effector function to altered functionality to prevent immunopathology, with potential differences between cancer and chronic infection.
Journal ArticleDOI
Turning Cold into Hot: Firing up the Tumor Microenvironment.
TL;DR: How innate immune sensing machinery, genetic alterations of oncogenic signaling, cellular metabolism, and epigenetic factors are involved in modulating the TME are discussed.
Journal ArticleDOI
Immune checkpoint signaling and cancer immunotherapy.
Xing He,Chenqi Xu,Chenqi Xu +2 more
TL;DR: Regulation of immune checkpoint signaling at multiple levels is discussed to provide an overview of the current understanding of checkpoint biology and includes the regulation of surface expression levels for known immune checkpoint proteins via surface delivery, internalization, recycling, and degradation.
Journal ArticleDOI
Cancer cell-derived exosomal circUHRF1 induces natural killer cell exhaustion and may cause resistance to anti-PD1 therapy in hepatocellular carcinoma
Peng-Fei Zhang,Peng-Fei Zhang,Chao Gao,Chao Gao,Xiao-Yong Huang,Xiao-Yong Huang,Jia-Cheng Lu,Jia-Cheng Lu,Xiao-Jun Guo,Xiao-Jun Guo,Guo-Ming Shi,Guo-Ming Shi,Jia-Bin Cai,Jia-Bin Cai,Ai-Wu Ke,Ai-Wu Ke +15 more
TL;DR: The expression of circUHRF1 is higher in human HCC tissues than in matched adjacent nontumor tissues and may drive resistance to anti-PD1 immunotherapy in HCC patients, indicating poor clinical prognosis and NK cell dysfunction in patients with HCC.
Journal ArticleDOI
A purified membrane protein from Akkermansia muciniphila or the pasteurised bacterium blunts colitis associated tumourigenesis by modulation of CD8+ T cells in mice
Lijuan Wang,Lei Tang,Yiming Feng,Suying Zhao,Mei Han,Chuan Zhang,Ge-hui Yuan,Jun Zhu,Shuyuan Cao,Qian Wu,Lei Li,Zhan Zhang +11 more
TL;DR: Data indicate that pasteurised A. muciniphila or Amuc_1100 can blunt colitis and CAC through the modulation of CTLs.
References
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Journal ArticleDOI
PD-1 and its ligands in tolerance and immunity
TL;DR: Current understanding of the immunoregulatory functions of PD-1 and its ligands and their therapeutic potential are discussed and an inhibitory bidirectional interaction between PD-L1 and B7-1 is discovered, revealing new ways the B7:CD28 family regulates T cell activation and tolerance.
Journal ArticleDOI
Cancer immunotherapy using checkpoint blockade
TL;DR: New-generation combinatorial therapies may overcome resistance mechanisms to immune checkpoint therapy, and evidence points to alterations that converge on the antigen presentation and interferon-γ signaling pathways.
Journal ArticleDOI
T cell exhaustion
TL;DR: Advances in the molecular delineation of T cell exhaustion are clarifying the underlying causes of this state of differentiation and also suggest promising therapeutic opportunities.
Journal ArticleDOI
Molecular and cellular insights into T cell exhaustion
E. John Wherry,Makoto Kurachi +1 more
TL;DR: Recent advances that provide a clearer molecular understanding of T cell exhaustion are reviewed and reveal new therapeutic targets for persisting infections and cancer.
Journal ArticleDOI
Fundamental Mechanisms of Immune Checkpoint Blockade Therapy
TL;DR: The current state of understanding of T-cell costimulatory mechanisms and checkpoint blockade, primarily of CTLA4 and PD-1, is reviewed, and conceptual gaps in knowledge are highlighted.
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