Journal ArticleDOI
Transferrin-conjugated magnetic silica PLGA nanoparticles loaded with doxorubicin and paclitaxel for brain glioma treatment.
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TLDR
MNP-MSN-PLGA-Tf NPs are promising carriers for the delivery of dual drugs for effective treatment of brain glioma and could be enhanced by the presence of magnetic field and the usage of Tf as targeting ligand.About:
This article is published in Biomaterials.The article was published on 2013-11-01. It has received 309 citations till now.read more
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The Synthesis and Properties of a New Carrier for Paclitaxel and Doxorubicin Based on the Amphiphilic Copolymer of N‐vinyl‐2‐pyrrolidone and Acrylic Acid
Anna M. Nechaeva,A. A. Artyukhov,Anna L. Luss,Mikhail I. Shtilman,Alina Y. Svistunova,Mikhail V. Motyakin,Irina I. Levina,E. G. Krivoborodov,Ilya Yu. Toropygin,E. M. Chistyakov,Aristidis Tsatsakis,Leonid Gurevich,Ya. O. Mezhuev +12 more
TL;DR: In this paper , the authors developed polymeric nanocarriers based on amphiphilic copolymers of N-vinyl-2-pyrrolidone and acrylic acid of various molecular weights.
Journal ArticleDOI
Nose-to-brain delivery of paliperidone palmitate poloxamer-guar gum nanogel: Formulation, optimization and pharmacological studies in rats.
TL;DR: In this article , the authors formulated, designed, optimized, and investigated the therapeutic potency of PPD-loaded intranasal in-situ gel (PPGISG) in the treatment of schizophrenia.
Journal ArticleDOI
Targeted nano-delivery of chemotherapy via intranasal route suppresses in vivo glioblastoma growth and prolongs survival in the intracranial mouse model
Puja Sandbhor,Jayant Sastri Goda,Bhabani Mohanty,Poonam Gera,Sandhya Yadav,Godanjali Chekuri,Pradip Chaudhari,Shilpee Dutt,Rinti Banerjee +8 more
TL;DR: The present study demonstrates the anti-glioma effect of the dual drug combination of PTX and proapoptotic HePc lipid-based transferrin receptor (TfR) targeted alternative delivery of the nanoparticulate system and indicates that the nasal delivery of targeted synergistic nanocarrier holds great promise as a non-invasive adjuvant chemotherapy therapy of GBM.
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Poly(2-oxazoline)-magnetite NanoFerrogels: Magnetic field responsive theranostic platform for cancer drug delivery and imaging
TL;DR: NanoFerrogels have been used as drug loading compartment for cancer diagnosis and treatment in this paper , where the authors developed six formulations with magnetic nanoparticle content of 0.3-12% with the z-average sizes of 85-130 nm and ξ-potential of 2.7-28.3 mV.
References
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Journal ArticleDOI
Mesoporous Silica Nanoparticles for Intracellular Controlled Drug Delivery
TL;DR: The latest research on the pathways of entry into live mammalian and plant cells together with intracellular trafficking are described, and the current research progress on the biocompatibility of this material in vitro and in vivo is discussed.
Journal ArticleDOI
Mesoporous Silica-Coated Gold Nanorods as a Light-Mediated Multifunctional Theranostic Platform for Cancer Treatment
Zhenjiang Zhang,Liming Wang,Jing Wang,Xiumei Jiang,Xiaohui Li,Zhijian Hu,Yinglu Ji,Xiaochun Wu,Chunying Chen +8 more
TL;DR: With doxorubicin hydrochloride loaded, Au@SiO(2)-DOX show two light-mediated therapeutic modes: low power density laser-triggered drug release for chemotherapy, and high powerdensity laser-induced hyperthermia, which suggest the potential for in-vivo applications.
Journal ArticleDOI
Superparamagnetic Iron Oxide Nanoparticle Probes for Molecular Imaging
TL;DR: The broad utility of superparamagnetic iron oxide nanoparticles in molecular imaging is illustrated, including some of the recent developments, such as the transformation of SPIO into an activatable probe termed the magnetic relaxation switch.
Journal ArticleDOI
Vascular Targeting Agents as Cancer Therapeutics
TL;DR: VTAs can kill indirectly the tumor cells that are resistant to conventional antiproliferative cancer therapies, i.e., cells in areas distant from blood vessels where drug penetration is poor, and hypoxia can lead to radiation and drug resistance.
Journal ArticleDOI
Aptamer-functionalized PEG–PLGA nanoparticles for enhanced anti-glioma drug delivery
Jianwei Guo,Xiaoling Gao,Lina Su,Lina Su,Huimin Xia,Guangzhi Gu,Zhiqing Pang,Xinguo Jiang,Lei Yao,Jun Chen,Hong-Zhuan Chen +10 more
TL;DR: The potential utility of AS1411-functionalized nanoparticles for a therapeutic application in the treatment of gliomas was demonstrated and significantly enhanced cellular association of nanoparticles in C6 glioma cells, and increased the cytotoxicity of its payload.
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