Tumor evolution: Linear, branching, neutral or punctuated?☆
TLDR
Data is discussed that supports the theory that most human tumors evolve from a single cell in the normal tissue, and suggests that models may change during tumor progression or operate concurrently for different classes of mutations.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2017-04-01 and is currently open access. It has received 255 citations till now. The article focuses on the topics: Tumor progression.read more
Citations
More filters
Journal ArticleDOI
The potential of liquid biopsies for the early detection of cancer.
TL;DR: Biology, technical complexities and clinical significance for early cancer detection and their impact on precision oncology are discussed.
Journal ArticleDOI
Tumor evolution and chemoresistance in ovarian cancer.
TL;DR: The recent advances in understanding ovarian cancer biology through the use of next generation sequencing (NGS) are discussed and areas of recent progress to improve precision medicine in ovarian cancer are highlighted.
Journal ArticleDOI
Breast tumours maintain a reservoir of subclonal diversity during expansion
Darlan Conterno Minussi,Michael D. Nicholson,Hanghui Ye,Alexander Davis,Kaile Wang,Toby Baker,Maxime Tarabichi,Emi Sei,Haowei Du,Mashiat Rabbani,Cheng Peng,Min Hu,Shanshan Bai,Yu-wei Lin,Aislyn Schalck,Asha S. Multani,Jin Ma,Tom O. McDonald,Anna Casasent,Angelica M. Gutierrez Barrera,Hui Chen,Bora Lim,Banu Arun,Funda Meric-Bernstam,Peter Van Loo,Franziska Michor,Nicholas Navin +26 more
TL;DR: In this article, a single-cell, single-molecule DNA-sequencing method was used to investigate copy number evolution during the expansion of primary breast tumours and showed that triple-negative breast cancers continue to evolve chromosome aberrations and maintain a reservoir of subclonal diversity during primary tumour growth.
Journal ArticleDOI
Comprehensive, integrated, and phased whole-genome analysis of the primary ENCODE cell line K562.
Bo Zhou,Steve S. Ho,Stephanie U. Greer,Xiaowei Zhu,John Bell,Joseph G. Arthur,Noah Spies,Xianglong Zhang,Seunggyu Byeon,Reenal Pattni,Noa Ben-Efraim,Michael S. Haney,Rajini R Haraksingh,Giltae Song,Hanlee P. Ji,Dimitri Perrin,Wing H. Wong,Alexej Abyzov,Alexander E. Urban +18 more
TL;DR: This comprehensive whole-genome analysis of K562 serves as a resource for future studies that utilize K562 as well as a framework for the analysis of other cancer genomes.
Journal ArticleDOI
Cancer evolution: Darwin and beyond
TL;DR: The role of macroevolutionary events in cancer initiation and progression is discussed in this paper, where the authors highlight clinical opportunities which can be grasped through targeting cancer vulnerabilities arising from non-Darwinian patterns of evolution.
References
More filters
Journal ArticleDOI
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
TL;DR: It is proposed that the metabolism of cancer cells, and indeed all proliferating cells, is adapted to facilitate the uptake and incorporation of nutrients into the biomass needed to produce a new cell.
Journal ArticleDOI
A genetic model for colorectal tumorigenesis
Eric R. Fearon,Bert Vogelstein +1 more
TL;DR: A model for the genetic basis of colorectal neoplasia that includes the following salient features is presented, which may be applicable to other common epithelial neoplasms, in which tumors of varying stage are more difficult to study.
Journal ArticleDOI
Intratumor heterogeneity and branched evolution revealed by multiregion sequencing.
Marco Gerlinger,Andrew Rowan,Stuart Horswell,James Larkin,David Endesfelder,Eva Grönroos,Pierre Martinez,Nicholas Matthews,Aengus Stewart,Patrick S. Tarpey,Ignacio Varela,Benjamin Phillimore,Sharmin Begum,Neil Q. McDonald,Adam Butler,David T. Jones,Keiran Raine,Calli Latimer,Claudio R. Santos,Mahrokh Nohadani,Aron Charles Eklund,Bradley Spencer-Dene,Graham Clark,Lisa Pickering,Gordon Stamp,Martin Gore,Zoltan Szallasi,Zoltan Szallasi,Julian Downward,P. Andrew Futreal,Charles Swanton +30 more
TL;DR: Intratumor heterogeneity can lead to underestimation of the tumor genomics landscape portrayed from single tumor-biopsy samples and may present major challenges to personalized-medicine and biomarker development.
Journal ArticleDOI
The clonal evolution of tumor cell populations
TL;DR: Each patient's cancer may require individual specific therapy, and even this may be thwarted by emergence of a genetically variant subline resistant to the treatment, which should be directed toward understanding and controlling the evolutionary process in tumors before it reaches the late stage usually seen in clinical cancer.
Journal ArticleDOI
MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling
Jeffrey A. Engelman,Kreshnik Zejnullahu,Tetsuya Mitsudomi,Youngchul Song,Courtney Hyland,Joon Oh Park,Neal I. Lindeman,Christopher-Michael Gale,Xiaojun Zhao,James J. Christensen,Takayuki Kosaka,Alison J. Holmes,Andrew M. Rogers,Federico Cappuzzo,Tony Mok,Charles Lee,Bruce E. Johnson,Lewis C. Cantley,Pasi A. Jänne +18 more
TL;DR: It is proposed that MET amplification may promote drug resistance in other ERBB-driven cancers as well after it was found that amplification of MET causes gefitinib resistance by driving ERBB3 (HER3)–dependent activation of PI3K, a pathway thought to be specific to EGFR/ERBB family receptors.
Related Papers (5)
Clonal Heterogeneity and Tumor Evolution: Past, Present, and the Future.
Intratumor heterogeneity and branched evolution revealed by multiregion sequencing.
Marco Gerlinger,Andrew Rowan,Stuart Horswell,James Larkin,David Endesfelder,Eva Grönroos,Pierre Martinez,Nicholas Matthews,Aengus Stewart,Patrick S. Tarpey,Ignacio Varela,Benjamin Phillimore,Sharmin Begum,Neil Q. McDonald,Adam Butler,David T. Jones,Keiran Raine,Calli Latimer,Claudio R. Santos,Mahrokh Nohadani,Aron Charles Eklund,Bradley Spencer-Dene,Graham Clark,Lisa Pickering,Gordon Stamp,Martin Gore,Zoltan Szallasi,Zoltan Szallasi,Julian Downward,P. Andrew Futreal,Charles Swanton +30 more