Tumor evolution: Linear, branching, neutral or punctuated?☆
TLDR
Data is discussed that supports the theory that most human tumors evolve from a single cell in the normal tissue, and suggests that models may change during tumor progression or operate concurrently for different classes of mutations.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2017-04-01 and is currently open access. It has received 255 citations till now. The article focuses on the topics: Tumor progression.read more
Citations
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Deciphering the chronology of copy number alterations in Multiple Myeloma
Anil Aktas Samur,Stephane Minvielle,Masood A. Shammas,Masood A. Shammas,Mariateresa Fulciniti,Florence Magrangeas,Paul G. Richardson,Philippe Moreau,Michel Attal,Kenneth C. Anderson,Giovanni Parmigiani,Hervé Avet-Loiseau,Nikhil C. Munshi,Nikhil C. Munshi,Mehmet Kemal Samur +14 more
TL;DR: The order of occurrence of these complex genomic events underlying MM development is comprehensively characterized using 500 MGUS, and MM samples and a timeline for copy number alteration is proposed.
Journal ArticleDOI
Computational approaches for inferring tumor evolution from single-cell genomic data
TL;DR: An overview of the state-of-the-art single-cell DNA sequencing methods, technical errors that are inherent in the resulting large-scale datasets, and computational methods to overcome these errors are presented.
Journal ArticleDOI
An enhanced genetic model of colorectal cancer progression history
Lixing Yang,Su Wang,June Koo Lee,Semin Lee,Semin Lee,Eunjung Lee,Eunjung Lee,Eve Shinbrot,David A. Wheeler,Raju Kucherlapati,Raju Kucherlapati,Peter J. Park,Peter J. Park +12 more
TL;DR: A refined tumor progression model is presented which significantly expands the understanding of the tumorigenic process of human colorectal cancer and reveals that selection is often present on subclones and that multiple evolutionary models can operate in a single tumor at different stages.
Journal ArticleDOI
Single-Cell Proteomic Profiling Identifies Combined AXL and JAK1 Inhibition as a Novel Therapeutic Strategy for Lung Cancer
Josephine A. Taverna,Chia Nung Hung,Chia Nung Hung,Daniel T. DeArmond,Meizhen Chen,Chun-Lin Lin,Pawel A. Osmulski,Maria Gaczynska,Chiou Miin Wang,Nicholas D. Lucio,Chih-Wei Chou,Chun Liang Chen,Alia Nazarullah,Shellye R. Lampkin,Lianqun Qiu,David J. Bearss,Steven L. Warner,Clifford J. Whatcott,Lars Mouritsen,Mark Wade,Steven D. Weitman,Ruben A. Mesa,Nameer B. Kirma,Wei-Ting Chao,Tim H M Huang +24 more
TL;DR: This study shows that single-cell proteomic profiling of treatment-naïve lung tumors, coupled with ex vivo testing of PDOs, identifies continuous AXL, TGFβ, and JAK1–STAT3 signal activation in select tumors that may be targeted by combined AXL–JAK1 inhibition.
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Understanding genomics and the immune environment of penile cancer to improve therapy
Ahmet M. Aydin,Jad Chahoud,Jacob J. Adashek,Mounsif Azizi,Anthony M. Magliocco,Jeffrey S. Ross,Jeffrey S. Ross,Andrea Necchi,Philippe E. Spiess +8 more
TL;DR: Penile squamous cell carcinoma (PSCC) displays a wide range of therapeutically targetable somatic alterations, and patients with treatment-resistant advanced PSCC might benefit from combined and sequential targeted therapies.
References
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TL;DR: It is proposed that the metabolism of cancer cells, and indeed all proliferating cells, is adapted to facilitate the uptake and incorporation of nutrients into the biomass needed to produce a new cell.
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