Tumor evolution: Linear, branching, neutral or punctuated?☆
TLDR
Data is discussed that supports the theory that most human tumors evolve from a single cell in the normal tissue, and suggests that models may change during tumor progression or operate concurrently for different classes of mutations.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2017-04-01 and is currently open access. It has received 255 citations till now. The article focuses on the topics: Tumor progression.read more
Citations
More filters
Journal ArticleDOI
Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution
Dian Yang,Matthew G. Jones,Santiago Naranjo,William M. Rideout,Kyung Hoi Min,Raymond Ho,Wei Wu,Joseph M. Replogle,Jennifer L. Page,Jeffrey J. Quinn,Felix Horns,Xiaojie Qiu,Michael Z. Chen,William A. Freed-Pastor,Christopher S. McGinnis,David M. Patterson,Zev J. Gartner,Eric D. Chow,Trever G. Bivona,Michelle Chan,Nir Yosef,Tyler Jacks,Jonathan S. Weissman +22 more
TL;DR: In this article , an evolving lineage-tracing system with a single-cell RNA-seq readout was introduced into a mouse model of Kras;Trp53(KP)-driven lung adenocarcinoma and tracked tumor evolution from single-transformed cells to metastatic tumors at unprecedented resolution.
Posted ContentDOI
Spatial structure governs the mode of tumour evolution
Robert Noble,Robert Noble,Burri D,Jakob Nikolas Kather,Jakob Nikolas Kather,Niko Beerenwinkel +5 more
TL;DR: Oncoevotypes are shown to be driven by differences in cell dispersal and cell-cell interactions, which it is shown are essential for accurately characterizing, forecasting and controlling tumour evolution.
Journal ArticleDOI
Cutaneous Papillomaviruses and Non-melanoma Skin Cancer: Causal Agents or Innocent Bystanders?
TL;DR: This overview summarizes not only recent arguments that favor the acceptance of a viral etiology in NMSC development but also reflects aspects of causality in medicine, the use of empirically meaningful model systems and strategies for prevention.
Journal ArticleDOI
Genomic evidence supports a clonal diaspora model for metastases of esophageal adenocarcinoma
Ayesha Noorani,Xiaodun Li,Martin Goddard,Jason Crawte,Ludmil B. Alexandrov,Maria Secrier,Matthew D. Eldridge,Lawrence Bower,Jamie M J Weaver,Pierre Lao-Sirieix,Inigo Martincorena,Irene Debiram-Beecham,Nicola Grehan,Shona MacRae,Shalini Malhotra,Ahmad Miremadi,Tabitha Thomas,Sarah Galbraith,Lorraine Petersen,Stephen D. Preston,David Gilligan,Andrew Hindmarsh,Richard H. Hardwick,Michael R. Stratton,David C. Wedge,Rebecca C. Fitzgerald +25 more
TL;DR: Whole-genome sequencing and phylogenetic analysis of nearly 400 esophageal adenocarcinoma samples suggest a model of rapid subclone spreading from the primary tumor to multiple metastatic sites, which the authors term ‘clonal diaspora’.
Journal ArticleDOI
Multiclonal tumor origin: Evidence and implications.
TL;DR: This review describes relevant studies of X chromosome inactivation, analyses of tumor heterogeneity using other markers, single cell sequencing, and lineage tracing studies in aggregation chimeras and engineered rodent models, and contests the commonly held assumption of monoclonal tumor origin.
References
More filters
Journal ArticleDOI
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
TL;DR: It is proposed that the metabolism of cancer cells, and indeed all proliferating cells, is adapted to facilitate the uptake and incorporation of nutrients into the biomass needed to produce a new cell.
Journal ArticleDOI
A genetic model for colorectal tumorigenesis
Eric R. Fearon,Bert Vogelstein +1 more
TL;DR: A model for the genetic basis of colorectal neoplasia that includes the following salient features is presented, which may be applicable to other common epithelial neoplasms, in which tumors of varying stage are more difficult to study.
Journal ArticleDOI
Intratumor heterogeneity and branched evolution revealed by multiregion sequencing.
Marco Gerlinger,Andrew Rowan,Stuart Horswell,James Larkin,David Endesfelder,Eva Grönroos,Pierre Martinez,Nicholas Matthews,Aengus Stewart,Patrick S. Tarpey,Ignacio Varela,Benjamin Phillimore,Sharmin Begum,Neil Q. McDonald,Adam Butler,David T. Jones,Keiran Raine,Calli Latimer,Claudio R. Santos,Mahrokh Nohadani,Aron Charles Eklund,Bradley Spencer-Dene,Graham Clark,Lisa Pickering,Gordon Stamp,Martin Gore,Zoltan Szallasi,Zoltan Szallasi,Julian Downward,P. Andrew Futreal,Charles Swanton +30 more
TL;DR: Intratumor heterogeneity can lead to underestimation of the tumor genomics landscape portrayed from single tumor-biopsy samples and may present major challenges to personalized-medicine and biomarker development.
Journal ArticleDOI
The clonal evolution of tumor cell populations
TL;DR: Each patient's cancer may require individual specific therapy, and even this may be thwarted by emergence of a genetically variant subline resistant to the treatment, which should be directed toward understanding and controlling the evolutionary process in tumors before it reaches the late stage usually seen in clinical cancer.
Journal ArticleDOI
MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling
Jeffrey A. Engelman,Kreshnik Zejnullahu,Tetsuya Mitsudomi,Youngchul Song,Courtney Hyland,Joon Oh Park,Neal I. Lindeman,Christopher-Michael Gale,Xiaojun Zhao,James J. Christensen,Takayuki Kosaka,Alison J. Holmes,Andrew M. Rogers,Federico Cappuzzo,Tony Mok,Charles Lee,Bruce E. Johnson,Lewis C. Cantley,Pasi A. Jänne +18 more
TL;DR: It is proposed that MET amplification may promote drug resistance in other ERBB-driven cancers as well after it was found that amplification of MET causes gefitinib resistance by driving ERBB3 (HER3)–dependent activation of PI3K, a pathway thought to be specific to EGFR/ERBB family receptors.
Related Papers (5)
Clonal Heterogeneity and Tumor Evolution: Past, Present, and the Future.
Intratumor heterogeneity and branched evolution revealed by multiregion sequencing.
Marco Gerlinger,Andrew Rowan,Stuart Horswell,James Larkin,David Endesfelder,Eva Grönroos,Pierre Martinez,Nicholas Matthews,Aengus Stewart,Patrick S. Tarpey,Ignacio Varela,Benjamin Phillimore,Sharmin Begum,Neil Q. McDonald,Adam Butler,David T. Jones,Keiran Raine,Calli Latimer,Claudio R. Santos,Mahrokh Nohadani,Aron Charles Eklund,Bradley Spencer-Dene,Graham Clark,Lisa Pickering,Gordon Stamp,Martin Gore,Zoltan Szallasi,Zoltan Szallasi,Julian Downward,P. Andrew Futreal,Charles Swanton +30 more