Tumor evolution: Linear, branching, neutral or punctuated?☆
TLDR
Data is discussed that supports the theory that most human tumors evolve from a single cell in the normal tissue, and suggests that models may change during tumor progression or operate concurrently for different classes of mutations.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2017-04-01 and is currently open access. It has received 255 citations till now. The article focuses on the topics: Tumor progression.read more
Citations
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Minimal barriers to invasion during human colorectal tumor growth.
Marc D. Ryser,Marc D. Ryser,Diego Mallo,Allison Hall,Timothy Hardman,Lorraine M. King,Sergei Tatishchev,Inmaculada C. Sorribes,Carlo C. Maley,Jeffrey R. Marks,Jeffrey R. Marks,E. Shelley Hwang,E. Shelley Hwang,Darryl Shibata +13 more
TL;DR: In colorectal cancer, the authors show that multiclonal invasion of the muscularis mucosae is pervasive, suggesting that invasive capacity is not a significant bottleneck in the evolution of the disease.
Journal ArticleDOI
Assessing the performance of methods for copy number aberration detection from single-cell DNA sequencing data.
TL;DR: A novel simulator of single-cell genome evolution in the presence of CNAs is developed and a phylogeny-based measure is introduced for identifying potentially erroneous inferences to assess performance on empirical data where the ground truth is unknown.
Journal ArticleDOI
Genetic and Non-Genetic Mechanisms Underlying Cancer Evolution.
TL;DR: In this article, an up-to-date view of the fundamental genetic and non-genetic mechanisms underlying tumour evolution is discussed with the aim of concurring into an integrated view of evolutionary forces at play throughout the emergence and progression of the disease and into the acquisition of resistance to diverse therapeutic paradigms.
Journal ArticleDOI
Reconstructing single-cell karyotype alterations in colorectal cancer identifies punctuated and gradual diversification patterns
Yannik Bollen,Yannik Bollen,Ellen Stelloo,Petra van Leenen,Myrna van den Bos,Bas Ponsioen,Bingxin Lu,Markus J. van Roosmalen,Ana C. F. Bolhaqueiro,Christopher Kimberley,Maximilian Mossner,William Cross,Nicolle Besselink,Bastiaan van der Roest,Sander Boymans,Koen C. Oost,Sippe G. de Vries,Holger Rehmann,Edwin Cuppen,Susanne M.A. Lens,Geert J. P. L. Kops,Wigard P. Kloosterman,Leon W.M.M. Terstappen,Chris P. Barnes,Andrea Sottoriva,Trevor A. Graham,Hugo J. Snippert +26 more
TL;DR: 3D Live-Seq as mentioned in this paper is a protocol that integrates live-cell imaging of tumor organoid outgrowth and whole-genome sequencing of each imaged cell to reconstruct evolving tumor cell karyotypes across consecutive cell generations.
Journal ArticleDOI
Lineage-defined leiomyosarcoma subtypes emerge years before diagnosis and determine patient survival.
Nathaniel D. Anderson,Yael Babichev,Fabio Fuligni,Federico Comitani,Mehdi Layeghifard,Rosemarie Venier,Stefan C. Dentro,Anant Maheshwari,Sheena Guram,Claire Wunker,Claire Wunker,J. Drew Thompson,Kyoko E. Yuki,Huayun Hou,Matthew Zatzman,Nicholas Light,Marcus Q. Bernardini,Marcus Q. Bernardini,Jay S. Wunder,Jay S. Wunder,Jay S. Wunder,Irene L. Andrulis,Irene L. Andrulis,Peter C. Ferguson,Peter C. Ferguson,Peter C. Ferguson,Albiruni Ryan Abdul Razak,Carol J. Swallow,James J. Dowling,Rima Al-awar,Rima Al-awar,Richard Marcellus,Marjan Rouzbahman,Marjan Rouzbahman,Moritz Gerstung,Daniel Durocher,Daniel Durocher,Ludmil B. Alexandrov,Brendan C. Dickson,Brendan C. Dickson,Brendan C. Dickson,Rebecca A. Gladdy,Adam Shlien +42 more
TL;DR: This article analyzed 70 genomes and 130 transcriptomes of leiomyosarcomas, including multiple tumor regions and paired metastases, finding origins in distinct lineages and associations with survival, in addition to the early emergence of metastatic clones.
References
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Journal ArticleDOI
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
TL;DR: It is proposed that the metabolism of cancer cells, and indeed all proliferating cells, is adapted to facilitate the uptake and incorporation of nutrients into the biomass needed to produce a new cell.
Journal ArticleDOI
A genetic model for colorectal tumorigenesis
Eric R. Fearon,Bert Vogelstein +1 more
TL;DR: A model for the genetic basis of colorectal neoplasia that includes the following salient features is presented, which may be applicable to other common epithelial neoplasms, in which tumors of varying stage are more difficult to study.
Journal ArticleDOI
Intratumor heterogeneity and branched evolution revealed by multiregion sequencing.
Marco Gerlinger,Andrew Rowan,Stuart Horswell,James Larkin,David Endesfelder,Eva Grönroos,Pierre Martinez,Nicholas Matthews,Aengus Stewart,Patrick S. Tarpey,Ignacio Varela,Benjamin Phillimore,Sharmin Begum,Neil Q. McDonald,Adam Butler,David T. Jones,Keiran Raine,Calli Latimer,Claudio R. Santos,Mahrokh Nohadani,Aron Charles Eklund,Bradley Spencer-Dene,Graham Clark,Lisa Pickering,Gordon Stamp,Martin Gore,Zoltan Szallasi,Zoltan Szallasi,Julian Downward,P. Andrew Futreal,Charles Swanton +30 more
TL;DR: Intratumor heterogeneity can lead to underestimation of the tumor genomics landscape portrayed from single tumor-biopsy samples and may present major challenges to personalized-medicine and biomarker development.
Journal ArticleDOI
The clonal evolution of tumor cell populations
TL;DR: Each patient's cancer may require individual specific therapy, and even this may be thwarted by emergence of a genetically variant subline resistant to the treatment, which should be directed toward understanding and controlling the evolutionary process in tumors before it reaches the late stage usually seen in clinical cancer.
Journal ArticleDOI
MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling
Jeffrey A. Engelman,Kreshnik Zejnullahu,Tetsuya Mitsudomi,Youngchul Song,Courtney Hyland,Joon Oh Park,Neal I. Lindeman,Christopher-Michael Gale,Xiaojun Zhao,James J. Christensen,Takayuki Kosaka,Alison J. Holmes,Andrew M. Rogers,Federico Cappuzzo,Tony Mok,Charles Lee,Bruce E. Johnson,Lewis C. Cantley,Pasi A. Jänne +18 more
TL;DR: It is proposed that MET amplification may promote drug resistance in other ERBB-driven cancers as well after it was found that amplification of MET causes gefitinib resistance by driving ERBB3 (HER3)–dependent activation of PI3K, a pathway thought to be specific to EGFR/ERBB family receptors.
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