Tumor evolution: Linear, branching, neutral or punctuated?☆
TLDR
Data is discussed that supports the theory that most human tumors evolve from a single cell in the normal tissue, and suggests that models may change during tumor progression or operate concurrently for different classes of mutations.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2017-04-01 and is currently open access. It has received 255 citations till now. The article focuses on the topics: Tumor progression.read more
Citations
More filters
SF-010-4 Distant metastasis occurs late during the genetic evolution of pancreatic cancer
TL;DR: A quantitative analysis of the timing of the genetic evolution of pancreatic cancer was performed, indicating at least a decade between the occurrence of the initiating mutation and the birth of the parental, non-metastatic founder cell.
Journal ArticleDOI
Epigenetic plasticity and the hallmarks of cancer
TL;DR: It is proposed that chromatin and epigenetic aberrations have the potential to confer on cells the full range of oncogenic properties represented in the classic “hallmarks” depiction of cancer, and it is suggested that genetic, environmental, and metabolic factors can make chromatin aberrantly permissive or restrictive.
Journal ArticleDOI
Eleven grand challenges in single-cell data science
David Lähnemann,David Lähnemann,Johannes Köster,Johannes Köster,Ewa Szczurek,Davis J. McCarthy,Davis J. McCarthy,Stephanie C. Hicks,Mark D. Robinson,Catalina A. Vallejos,Catalina A. Vallejos,Kieran R Campbell,Kieran R Campbell,Niko Beerenwinkel,Niko Beerenwinkel,Ahmed Mahfouz,Ahmed Mahfouz,Luca Pinello,Luca Pinello,Pavel Skums,Alexandros Stamatakis,Alexandros Stamatakis,Camille Stephan Otto Attolini,Samuel Aparicio,Samuel Aparicio,Jasmijn A. Baaijens,Marleen Balvert,Marleen Balvert,Buys de Barbanson,Antonio Cappuccio,Giacomo Corleone,Bas E. Dutilh,Bas E. Dutilh,Maria Florescu,Victor Guryev,Rens Holmer,Katharina Jahn,Katharina Jahn,Thamar Jessurun Lobo,Emma M. Keizer,Indu Khatri,Szymon M. Kielbasa,Jan O. Korbel,Alexey M. Kozlov,Tzu Hao Kuo,Boudewijn P. F. Lelieveldt,Boudewijn P. F. Lelieveldt,Ion I. Mandoiu,John C. Marioni,John C. Marioni,John C. Marioni,Tobias Marschall,Tobias Marschall,Felix Mölder,Amir Niknejad,Lukasz Raczkowski,Marcel J. T. Reinders,Marcel J. T. Reinders,Jeroen de Ridder,Antoine-Emmanuel Saliba,Antonios Somarakis,Oliver Stegle,Oliver Stegle,Fabian J. Theis,Huan Yang,Alexander Zelikovsky,Alexander Zelikovsky,Alice C. McHardy,Benjamin J. Raphael,Sohrab P. Shah,Alexander Schönhuth,Alexander Schönhuth +71 more
TL;DR: This compendium is for established researchers, newcomers, and students alike, highlighting interesting and rewarding problems for the coming years in single-cell data science.
Journal ArticleDOI
Tumour heterogeneity and metastasis at single-cell resolution.
TL;DR: Recent advances in single-cell technologies are reviewed and discussed in detail how they can be leveraged to understand tumour heterogeneity and metastasis.
Inference of Tumor Evolution during Chemotherapy by Computational Modeling and In Situ Analysis of Genetic and Phenotypic Cellular Diversity
Vanessa Almendro,Yu-Kang Cheng,Amanda Randles,Shalev Itzkovitz,Andriy Marusyk,Elisabet Ametller,Xavier Gonzalez-Farre,Hege G. Russnes,Inga H. Rye,Anne Lise Børresen-Dale,Reo Maruyama,Alexander van Oudenaarden,Mitchell Dowsett,Robin L. Jones,Jorge S. Reis-Filho,Pere Gascón,Franziska Michor,Kornelia Polyak,Montse Muñoz,Åslaug Helland,Mithat Gonen +20 more
TL;DR: The analysis of cellular heterogeneity for genetic and phenotypic features and their spatial distribution in breast tumors pre- and post-neoadjuvant chemotherapy found that intratumor genetic diversity was tumor-subtype specific, and it did not change during treatment in tumors with partial or no response.
References
More filters
Journal ArticleDOI
Spatial and temporal diversity in genomic instability processes defines lung cancer evolution
Elza C de Bruin,Nicholas McGranahan,Nicholas McGranahan,Richard Mitter,Max Salm,David C. Wedge,Lucy R. Yates,Lucy R. Yates,Mariam Jamal-Hanjani,Seema Shafi,Nirupa Murugaesu,Andrew Rowan,Eva Grönroos,Madiha A. Muhammad,Stuart Horswell,Marco Gerlinger,Ignacio Varela,David T. Jones,John Marshall,Thierry Voet,Thierry Voet,Peter Van Loo,Peter Van Loo,Doris Rassl,Robert C. Rintoul,Sam M. Janes,Siow Ming Lee,Martin Forster,Tanya Ahmad,David Lawrence,Mary Falzon,Arrigo Capitanio,Timothy T. Harkins,Clarence C. Lee,Warren Tom,Enock Teefe,Shann-Ching Chen,Sharmin Begum,Adam Rabinowitz,Benjamin Phillimore,Bradley Spencer-Dene,Gordon Stamp,Zoltan Szallasi,Zoltan Szallasi,Nik Matthews,Aengus Stewart,Peter J. Campbell,Charles Swanton,Charles Swanton +48 more
TL;DR: 25 spatially distinct regions from seven operable NSCLCs were sequenced and found evidence of branched evolution, with driver mutations arising before and after subclonal diversification, and pronounced intratumor heterogeneity in copy number alterations, translocations, and mutations associated with APOBEC cytidine deaminase activity.
Journal ArticleDOI
Clonal evolution in breast cancer revealed by single nucleus genome sequencing
Yong Wang,Jill Waters,Marco L. Leung,Anna K. Unruh,Whijae Roh,Xiuqing Shi,Ken Chen,Paul Scheet,Selina Vattathil,Han Liang,Asha S. Multani,Hong Zhang,Rui Zhao,Franziska Michor,Funda Meric-Bernstam,Nicholas Navin +15 more
TL;DR: The data show that aneuploid rearrangements occurred early in tumour evolution and remained highly stable as the tumour masses clonally expanded, which has important implications for the diagnosis, therapeutic treatment and evolution of chemoresistance in breast cancer.
Journal ArticleDOI
Biological and Therapeutic Impact of Intratumor Heterogeneity in Cancer Evolution
TL;DR: The processes shaping the cancer genome are explored, placing these within the context of tumor evolution and their impact on intratumor heterogeneity and drug development.
Journal ArticleDOI
Chromothripsis from DNA damage in micronuclei
Cheng-Zhong Zhang,Alexander Spektor,Hauke Cornils,Joshua M. Francis,Emily K. Jackson,Shiwei Liu,Matthew Meyerson,David Pellman +7 more
TL;DR: It is demonstrated that micronucleus formation can indeed generate a spectrum of genomic rearrangements, some of which recapitulate all known features of chromothripsis.
Journal ArticleDOI
A decade’s perspective on DNA sequencing technology
TL;DR: The decade since the Human Genome Project ended has witnessed a remarkable sequencing technology explosion that has permitted a multitude of questions to be asked and answered, at unprecedented speed and resolution.
Related Papers (5)
Clonal Heterogeneity and Tumor Evolution: Past, Present, and the Future.
Intratumor heterogeneity and branched evolution revealed by multiregion sequencing.
Marco Gerlinger,Andrew Rowan,Stuart Horswell,James Larkin,David Endesfelder,Eva Grönroos,Pierre Martinez,Nicholas Matthews,Aengus Stewart,Patrick S. Tarpey,Ignacio Varela,Benjamin Phillimore,Sharmin Begum,Neil Q. McDonald,Adam Butler,David T. Jones,Keiran Raine,Calli Latimer,Claudio R. Santos,Mahrokh Nohadani,Aron Charles Eklund,Bradley Spencer-Dene,Graham Clark,Lisa Pickering,Gordon Stamp,Martin Gore,Zoltan Szallasi,Zoltan Szallasi,Julian Downward,P. Andrew Futreal,Charles Swanton +30 more