Tumor evolution: Linear, branching, neutral or punctuated?☆
TLDR
Data is discussed that supports the theory that most human tumors evolve from a single cell in the normal tissue, and suggests that models may change during tumor progression or operate concurrently for different classes of mutations.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2017-04-01 and is currently open access. It has received 255 citations till now. The article focuses on the topics: Tumor progression.read more
Citations
More filters
Journal ArticleDOI
Rapid progressive lung cancers harbouring multiple clonal driver mutations with big bang evolution model.
Kei Kunimasa,Yosuke Hirotsu,Harumi Nakamura,Motohiro Tamiya,Yuki Iijima,Hiroto Ishida,Yuichiro Hamamoto,Tomohiro Maniwa,Toru Kimura,Kazumi Nishino,Taichiro Goto,Kenji Amemiya,Hitoshi Mochizuki,Toshio Oyama,Shin-ichi Nakatsuka,Toru Kumagai,Jiro Okami,Masahiko Higashiyama,Fumio Imamura,Masao Omata +19 more
TL;DR: The authors' data suggested two lung cancers progressed with punctuated and big bang evolutional model, and should pay attention to clinical course of lung cancer patients harboring multiple clonal driver mutations in their primary lesions.
Journal ArticleDOI
The Genetics of Uveal Melanoma: Overview and Clinical Relevance.
TL;DR: In this article, it has been shown that uveal melanoma differs fundamentally from non-uveal melanomas and is an independent genetic subtype and has a low mutational burden compared to other tumours.
Journal ArticleDOI
The Genetic Evolution of Metastasis
TL;DR: In this paper , the authors discuss how these insights could inform clinical decision-making and uncover rational antimetastasis treatment strategies and discuss how they could be used to improve clinical decision making.
Journal ArticleDOI
Life Entrapped in a Network of Atavistic Attractors: How to Find a Rescue
TL;DR: A potentially universal model of cancer transformation and development supported by a proposed new model of cellular functionality evolution is presented and the methods of fighting cancer resulting from unified cell bioenergetics and the two presented models are considered.
Journal ArticleDOI
Single-cell RNA sequencing and bioinformatics as tools to decipher cancer heterogenicity and mechanisms of drug resistance.
TL;DR: In this paper, the role of single-cell RNA sequencing technologies in addressing cancer heterogeneity and cell lineage-dependent drug resistance is discussed, as well as their role in addressing carcinogenesis and drug resistance.
References
More filters
Journal ArticleDOI
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
TL;DR: It is proposed that the metabolism of cancer cells, and indeed all proliferating cells, is adapted to facilitate the uptake and incorporation of nutrients into the biomass needed to produce a new cell.
Journal ArticleDOI
A genetic model for colorectal tumorigenesis
Eric R. Fearon,Bert Vogelstein +1 more
TL;DR: A model for the genetic basis of colorectal neoplasia that includes the following salient features is presented, which may be applicable to other common epithelial neoplasms, in which tumors of varying stage are more difficult to study.
Journal ArticleDOI
Intratumor heterogeneity and branched evolution revealed by multiregion sequencing.
Marco Gerlinger,Andrew Rowan,Stuart Horswell,James Larkin,David Endesfelder,Eva Grönroos,Pierre Martinez,Nicholas Matthews,Aengus Stewart,Patrick S. Tarpey,Ignacio Varela,Benjamin Phillimore,Sharmin Begum,Neil Q. McDonald,Adam Butler,David T. Jones,Keiran Raine,Calli Latimer,Claudio R. Santos,Mahrokh Nohadani,Aron Charles Eklund,Bradley Spencer-Dene,Graham Clark,Lisa Pickering,Gordon Stamp,Martin Gore,Zoltan Szallasi,Zoltan Szallasi,Julian Downward,P. Andrew Futreal,Charles Swanton +30 more
TL;DR: Intratumor heterogeneity can lead to underestimation of the tumor genomics landscape portrayed from single tumor-biopsy samples and may present major challenges to personalized-medicine and biomarker development.
Journal ArticleDOI
The clonal evolution of tumor cell populations
TL;DR: Each patient's cancer may require individual specific therapy, and even this may be thwarted by emergence of a genetically variant subline resistant to the treatment, which should be directed toward understanding and controlling the evolutionary process in tumors before it reaches the late stage usually seen in clinical cancer.
Journal ArticleDOI
MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling
Jeffrey A. Engelman,Kreshnik Zejnullahu,Tetsuya Mitsudomi,Youngchul Song,Courtney Hyland,Joon Oh Park,Neal I. Lindeman,Christopher-Michael Gale,Xiaojun Zhao,James J. Christensen,Takayuki Kosaka,Alison J. Holmes,Andrew M. Rogers,Federico Cappuzzo,Tony Mok,Charles Lee,Bruce E. Johnson,Lewis C. Cantley,Pasi A. Jänne +18 more
TL;DR: It is proposed that MET amplification may promote drug resistance in other ERBB-driven cancers as well after it was found that amplification of MET causes gefitinib resistance by driving ERBB3 (HER3)–dependent activation of PI3K, a pathway thought to be specific to EGFR/ERBB family receptors.
Related Papers (5)
Clonal Heterogeneity and Tumor Evolution: Past, Present, and the Future.
Intratumor heterogeneity and branched evolution revealed by multiregion sequencing.
Marco Gerlinger,Andrew Rowan,Stuart Horswell,James Larkin,David Endesfelder,Eva Grönroos,Pierre Martinez,Nicholas Matthews,Aengus Stewart,Patrick S. Tarpey,Ignacio Varela,Benjamin Phillimore,Sharmin Begum,Neil Q. McDonald,Adam Butler,David T. Jones,Keiran Raine,Calli Latimer,Claudio R. Santos,Mahrokh Nohadani,Aron Charles Eklund,Bradley Spencer-Dene,Graham Clark,Lisa Pickering,Gordon Stamp,Martin Gore,Zoltan Szallasi,Zoltan Szallasi,Julian Downward,P. Andrew Futreal,Charles Swanton +30 more