Journal ArticleDOI
Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review.
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TLDR
The basic characteristics of the EPR effect, particularly the factors involved, are described, as well as its modulation for improving delivery of macromolecular drugs to the tumor.About:
This article is published in Journal of Controlled Release.The article was published on 2000-03-01. It has received 5955 citations till now. The article focuses on the topics: Enhanced permeability and retention effect & Vascular permeability.read more
Citations
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Tumor-penetrating peptide enhances transcytosis of silicasome-based chemotherapy for pancreatic cancer
Xiangsheng Liu,Paulina Lin,Ian Perrett,Joshua Lin,Yu-Pei Liao,Chong Hyun Chang,Jinhong Jiang,Nanping Wu,Timothy R. Donahue,Zev A. Wainberg,Andre E. Nel,Huan Meng +11 more
TL;DR: It is demonstrated that iRGD enhances the efficacy of irinotecan-loaded silicasome–based therapy and may be a suitable adjuvant in nanoparticle-based treatments for PDAC.
Journal ArticleDOI
Nanotechnology Applications in Surgical Oncology
TL;DR: Recent advances in nanotechnology and optical instrumentation are discussed, and how these advances can be integrated for applications in surgical oncology.
Journal ArticleDOI
Biodistribution and bioimaging studies of hybrid paclitaxel nanocrystals: lessons learned of the EPR effect and image-guided drug delivery.
Christin P. Hollis,Heidi L. Weiss,Markos Leggas,B. Mark Evers,Richard A. Gemeinhart,Tonglei Li +5 more
TL;DR: The divergent results suggest possible ways to improve the design of hybrid nanocrystals for cancer therapy and diagnosis and raises questions of the general role of the enhanced permeability and retention (EPR) effect in tumor targeting and the effectiveness of bioimaging, specifically for theranostics, in tracking drug distribution and pharmacokinetics.
Journal ArticleDOI
Applications and Limitations of Dendrimers in Biomedicine.
Adriana Aurelia Chis,Carmen Maximiliana Dobrea,Claudiu Morgovan,Anca Maria Arseniu,Luca Liviu Rus,Anca Butuca,Anca Maria Juncan,Maria Totan,Andreea Loredana Vonica-Tincu,Gabriela Cormos,Andrei Catalin Muntean,Maria Lucia Muresan,Felicia Gabriela Gligor,Adina Frum +13 more
TL;DR: Biomedicine represents one of the main study areas for dendrimers, which have proven to be valuable both in diagnostics and therapy, due to their capacity for improving solubility, absorption, bioavailability and targeted distribution.
Journal ArticleDOI
Synergistic cancer therapeutic effects of locally delivered drug and heat using multifunctional nanoparticles.
TL;DR: Near-infrared light of 650 ∼ 900 nm is applicable for in vivo imaging and therapy due to minimal optical absorption by intrinsic chromophores, such as hemoglobin and water, resulting in maximal penetration of light into biological tissues.
References
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Journal Article
A New Concept for Macromolecular Therapeutics in Cancer Chemotherapy: Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs
Yasuhiro Matsumura,Hiroshi Maeda +1 more
TL;DR: It is speculated that the tumoritropic accumulation of smancs and other proteins resulted because of the hypervasculature, an enhanced permeability to even macromolecules, and little recovery through either blood vessels or lymphatic vessels in tumors of tumor-bearing mice.
Journal ArticleDOI
Vascular endothelial growth factor is a secreted angiogenic mitogen
TL;DR: DNA sequencing suggests the existence of several molecular species of VEGF, a heparin-binding growth factor specific for vascular endothelial cells that is able to induce angiogenesis in vivo.
Journal ArticleDOI
Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid.
Donald R. Senger,Stephen J. Galli,Ann M. Dvorak,Carole A. Perruzzi,V. Susan Harvey,Harold F. Dvorak +5 more
TL;DR: Tumor ascites fluids from guinea pigs, hamsters, and mice contain activity that rapidly increases microvascular permeability, and this activity is secreted by these tumor cells and a variety of other tumor cell lines in vitro.
Journal Article
Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis.
TL;DR: T tumors have "borrowed" fundamental mechanisms that developed in multicellular organisms for purposes of tissue defense, renewal, and repair and taught us something new about angiogenesis, namely, that vascular hyperpermeability and consequent plasma protein extravasation are important, perhaps essential, elements in its generation.
Journal ArticleDOI
Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells.
TL;DR: Both short- and long-term exposure of human EC to VEGF stimulates the release of biologically active NO, suggesting that NO mediates aspects of V EGF signaling required for EC proliferation and organization in vitro.
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