Journal ArticleDOI
Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review.
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TLDR
The basic characteristics of the EPR effect, particularly the factors involved, are described, as well as its modulation for improving delivery of macromolecular drugs to the tumor.About:
This article is published in Journal of Controlled Release.The article was published on 2000-03-01. It has received 5955 citations till now. The article focuses on the topics: Enhanced permeability and retention effect & Vascular permeability.read more
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Liposomes as ‘smart’ pharmaceutical nanocarriers
TL;DR: The evolution of liposomes with emphasis on the recent advances in stimuli-sensitive liposome has been reviewed.
Journal ArticleDOI
Theoretical and Computational Investigations of Nanoparticle–Biomembrane Interactions in Cellular Delivery
TL;DR: In this review, the current status and perspective of theoretical and computational investigations is presented on the nanoparticle-biomembrane interactions in cellular delivery, and the determining parameters that govern the cellular uptake of nanoparticles are discussed.
Journal ArticleDOI
Nanoshells with Targeted Simultaneous Enhancement of Magnetic and Optical Imaging and Photothermal Therapeutic Response
Rizia Bardhan,Wenxue Chen,Carlos J. Perez-Torres,Marc Bartels,Ryan Huschka,Liang L. Zhao,Emilia Morosan,Robia G. Pautler,Amit Joshi,Naomi J. Halas +9 more
TL;DR: The ability to enhance two different imaging technologies simultaneously—fluorescence optical imaging and magnetic resonance imaging—with antibody targeting and photothermal therapeutic actuation is combined all within the same nanoshell‐based complex.
Journal ArticleDOI
Future directions of liposome- and immunoliposome-based cancer therapeutics.
TL;DR: The modular organization of immunoliposome technology enables a combinatorial approach in which a repertoire of monoclonal antibody fragments can be used in conjunction with a series of liposomal drugs to yield a new generation of molecularly targeted agents.
Journal ArticleDOI
Iron oxide-based nanostructures for MRI and magnetic hyperthermia
Ingrid Hilger,Werner A. Kaiser +1 more
TL;DR: Owing to the versatility of nanoparticles, researchers envision the combination of multiple modalities to one carrier, which has been challenging due to the necessity of the adaptation of at least partially counteracting parameters between the different modalities.
References
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Journal Article
A New Concept for Macromolecular Therapeutics in Cancer Chemotherapy: Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs
Yasuhiro Matsumura,Hiroshi Maeda +1 more
TL;DR: It is speculated that the tumoritropic accumulation of smancs and other proteins resulted because of the hypervasculature, an enhanced permeability to even macromolecules, and little recovery through either blood vessels or lymphatic vessels in tumors of tumor-bearing mice.
Journal ArticleDOI
Vascular endothelial growth factor is a secreted angiogenic mitogen
TL;DR: DNA sequencing suggests the existence of several molecular species of VEGF, a heparin-binding growth factor specific for vascular endothelial cells that is able to induce angiogenesis in vivo.
Journal ArticleDOI
Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid.
Donald R. Senger,Stephen J. Galli,Ann M. Dvorak,Carole A. Perruzzi,V. Susan Harvey,Harold F. Dvorak +5 more
TL;DR: Tumor ascites fluids from guinea pigs, hamsters, and mice contain activity that rapidly increases microvascular permeability, and this activity is secreted by these tumor cells and a variety of other tumor cell lines in vitro.
Journal Article
Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis.
TL;DR: T tumors have "borrowed" fundamental mechanisms that developed in multicellular organisms for purposes of tissue defense, renewal, and repair and taught us something new about angiogenesis, namely, that vascular hyperpermeability and consequent plasma protein extravasation are important, perhaps essential, elements in its generation.
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Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells.
TL;DR: Both short- and long-term exposure of human EC to VEGF stimulates the release of biologically active NO, suggesting that NO mediates aspects of V EGF signaling required for EC proliferation and organization in vitro.
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