Journal ArticleDOI
Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review.
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TLDR
The basic characteristics of the EPR effect, particularly the factors involved, are described, as well as its modulation for improving delivery of macromolecular drugs to the tumor.About:
This article is published in Journal of Controlled Release.The article was published on 2000-03-01. It has received 5955 citations till now. The article focuses on the topics: Enhanced permeability and retention effect & Vascular permeability.read more
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Principles of nanoparticle design for overcoming biological barriers to drug delivery
TL;DR: By successively addressing each of the biological barriers that a particle encounters upon intravenous administration, innovative design features can be rationally incorporated that will create a new generation of nanotherapeutics, realizing a paradigmatic shift in nanoparticle-based drug delivery.
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Drug Delivery Systems: Entering the Mainstream
TL;DR: There is considerable interest in exploiting the advantages of DDS for in vivo delivery of new drugs derived from proteomics or genomics research and for their use in ligand-targeted therapeutics.
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Nanoparticles in cancer therapy and diagnosis
TL;DR: The in vivo fate of these systems, after intravascular or tumoral administration, is discussed, as well as the mechanism involved in tumor regression, and the application of nanoparticles in imaging for cancer diagnosis is focused on.
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Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives
TL;DR: PEG is the most used polymer and also the gold standard for stealth polymers in the emerging field of polymer-based drug delivery and alternative polymers will be evaluated.
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The golden age: gold nanoparticles for biomedicine
TL;DR: It is argued that gold nanotechnology-enabled biomedicine is not simply an act of 'gilding the (nanomedicinal) lily', but that a new 'Golden Age' of biomedical nanotechnology is truly upon us.
References
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Journal ArticleDOI
Induction of haem oxygenase-1 by nitric oxide and ischaemia in experimental solid tumours and implications for tumour growth
Koichi Doi,Takaaki Akaike,Shigemoto Fujii,S Tanaka,Norisato Ikebe,Toru Beppu,Shigeki Shibahara,Michio Ogawa,Hiroshi Maeda +8 more
TL;DR: HO-1 expression in the solid tumour may confer resistance of tumour cells to hypoxic stress as well as to NO-mediated cytotoxicity, and it is of great importance that an HO inhibitor, zinc protoporphyrin IX injected intra-arterially to the solid tumor suppressed the tumour growth to a great extent.
Journal ArticleDOI
Generation of an angiostatin-like fragment from plasminogen by stromelysin-1 (MMP-3).
TL;DR: Proteolytic cleavage of plasminogen by MMP-3 generates angiostatin-like fragments and is mediated via the miniplAsminogen moiety (kringle 5 plus the proteinase domain) and via the catalytic domain of M MP-3.
Journal ArticleDOI
An essential arginyl residue at the nucleotide binding site of creatine kinase.
C. L. Borders,James F. Riordan +1 more
TL;DR: The data suggest that an arginyl residue plays an essential role in the enzymatic mechanism of creatine kinase, probably as a recognition site for the negatively charged oligophosphate moiety of the nucleotide.
Journal ArticleDOI
Activation of hageman factor and prekallikrein and generation of kinin by various microbial proteinases.
TL;DR: The enhancement of vascular permeability in guinea pig skin and its sensitivity to inhibitors of activated Hageman factor, plasma kallikrein, or a kininase were examined and the results from the in vivo experiments were consistent with those in vitro.
Journal ArticleDOI
Excessive production of nitric oxide in rat solid tumor and its implication in rapid tumor growth
Koichi Doi,Takaaki Akaike,Hidechika Horie,Youichiro Noguchi,Shigemoto Fujii,Toru Beppu,Michio Ogawa,Hiroshi Maeda +7 more
TL;DR: The role of NO in solid tumor pathology was further investigated in animal tumor and a possible connection between nitric oxide (NO) and enhanced vascular permeability in solid tumors was reported.
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Yasuhiro Matsumura,Hiroshi Maeda +1 more