Journal ArticleDOI
Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review.
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TLDR
The basic characteristics of the EPR effect, particularly the factors involved, are described, as well as its modulation for improving delivery of macromolecular drugs to the tumor.About:
This article is published in Journal of Controlled Release.The article was published on 2000-03-01. It has received 5955 citations till now. The article focuses on the topics: Enhanced permeability and retention effect & Vascular permeability.read more
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Doxorubicin–polyphosphazene conjugate hydrogels for locally controlled delivery of cancer therapeutics
TL;DR: The conjugate hydrogel after the local injection at the tumor site was shown to inhibit tumor growth more effectively with less toxicity and much longer than doxorubicin and saline as controls, indicating that tumor active DOX from the conjugates is released slowly over a longer period of time and effectively accumulated locally in the tumor sites.
Journal ArticleDOI
Liposomes targeted via two different antibodies: Assay, B-cell binding and cytotoxicity
TL;DR: It is hypothesize that liposomes targeted via antibodies against two or more receptor populations will increase the apparent receptor density on the target cells, resulting in improved therapeutic affects, and selective toxicity of anticancer drugs can be improved with the use of antibody-targetedliposomes.
Journal ArticleDOI
A theranostic prodrug delivery system based on Pt(IV) conjugated nano-graphene oxide with synergistic effect to enhance the therapeutic efficacy of Pt drug.
Jingwen Li,Zhonglin Lyv,Yanli Li,Huan Liu,Jinkui Wang,Wenjun Zhan,Hong Chen,Huabing Chen,Xinming Li +8 more
TL;DR: This nanocomposite displays a synergistic effect in improving the therapeutic efficacy of the Pt drug with complete destruction of tumors, no tumor recurrence and minimal systemic toxicity in comparison with chemotherapy or photothermal treatment alone, highlighting the advantageous effects of integrating Pt(IV) with GO for anticancer treatment.
Journal ArticleDOI
Intraoperative imaging of folate receptor alpha positive ovarian and breast cancer using the tumor specific agent EC17
Quirijn R.J.G. Tummers,Charlotte E.S. Hoogstins,Katja N. Gaarenstroom,Cor D. de Kroon,Mariëtte I.E. van Poelgeest,Jaap Vuyk,Tjalling Bosse,Vincent T.H.B.M. Smit,Cornelis J.H. van de Velde,Adam F. Cohen,Philip S. Low,Jacobus Burggraaf,Alexander L. Vahrmeijer +12 more
TL;DR: FRα is a favorable target for fluorescence-guided surgery as EC17 produced a clear fluorescent signal in ovarian and breast cancer tissue, which resulted in resection of ovarian cancer lesions that were otherwise not detected.
Journal ArticleDOI
Biodegradable intraocular therapies for retinal disorders: progress to date.
Noriyuki Kuno,Shinobu Fujii +1 more
TL;DR: The most developed biodegradable device, Ozurdex™ (dexamethasone intravitreal implant), is approved as first-line therapy for the treatment of macular oedema following branchretinal vein occlusion or central retinal vein Occlusion.
References
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Journal Article
A New Concept for Macromolecular Therapeutics in Cancer Chemotherapy: Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs
Yasuhiro Matsumura,Hiroshi Maeda +1 more
TL;DR: It is speculated that the tumoritropic accumulation of smancs and other proteins resulted because of the hypervasculature, an enhanced permeability to even macromolecules, and little recovery through either blood vessels or lymphatic vessels in tumors of tumor-bearing mice.
Journal ArticleDOI
Vascular endothelial growth factor is a secreted angiogenic mitogen
TL;DR: DNA sequencing suggests the existence of several molecular species of VEGF, a heparin-binding growth factor specific for vascular endothelial cells that is able to induce angiogenesis in vivo.
Journal ArticleDOI
Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid.
Donald R. Senger,Stephen J. Galli,Ann M. Dvorak,Carole A. Perruzzi,V. Susan Harvey,Harold F. Dvorak +5 more
TL;DR: Tumor ascites fluids from guinea pigs, hamsters, and mice contain activity that rapidly increases microvascular permeability, and this activity is secreted by these tumor cells and a variety of other tumor cell lines in vitro.
Journal Article
Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis.
TL;DR: T tumors have "borrowed" fundamental mechanisms that developed in multicellular organisms for purposes of tissue defense, renewal, and repair and taught us something new about angiogenesis, namely, that vascular hyperpermeability and consequent plasma protein extravasation are important, perhaps essential, elements in its generation.
Journal ArticleDOI
Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells.
TL;DR: Both short- and long-term exposure of human EC to VEGF stimulates the release of biologically active NO, suggesting that NO mediates aspects of V EGF signaling required for EC proliferation and organization in vitro.
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Yasuhiro Matsumura,Hiroshi Maeda +1 more