Journal ArticleDOI
Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review.
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TLDR
The basic characteristics of the EPR effect, particularly the factors involved, are described, as well as its modulation for improving delivery of macromolecular drugs to the tumor.About:
This article is published in Journal of Controlled Release.The article was published on 2000-03-01. It has received 5955 citations till now. The article focuses on the topics: Enhanced permeability and retention effect & Vascular permeability.read more
Citations
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In vivo small animal micro-CT using nanoparticle contrast agents.
TL;DR: This review focuses on new developments for in vivo small animal micro-CT using novel nanoparticle probes applied in preclinical research by adding spectral capabilities to separate multiple co-injected nanoparticles in vivo.
Journal ArticleDOI
β-Lapachone Micellar Nanotherapeutics for Non–Small Cell Lung Cancer Therapy
Elvin Blanco,Erik A. Bey,Chalermchai Khemtong,Su-Geun Yang,Jagadeesh Setti-Guthi,Huabing Chen,Chase W. Kessinger,Kevin A. Carnevale,William G. Bornmann,David A. Boothman,Jinming Gao +10 more
TL;DR: A clinically viable beta-lap nanomedicine platform with enhanced safety, pharmacokinetics, and antitumor efficacy for the specific treatment of NSCLC tumors is established.
Journal ArticleDOI
Ligand-clustered "patchy" nanoparticles for modulated cellular uptake and in vivo tumor targeting.
Zhiyong Poon,Shujun Chen,Amanda C. Engler,Hyung-il Lee,Hyung-il Lee,Evrim Atas,Geoffrey von Maltzahn,Sangeeta N. Bhatia,Paula T. Hammond +8 more
TL;DR: The findings presented here suggest that the nature of ligand presentation on a nanoparticle surface may play an important role in drug targeting; the results suggest potential impact for other targeting moieties and provide a framework for further refinement of future multivalent targeting strategies.
Journal ArticleDOI
In Situ Cross-Linkable High Molecular Weight Hyaluronan−Bisphosphonate Conjugate for Localized Delivery and Cell-Specific Targeting: A Hydrogel Linked Prodrug Approach
TL;DR: The first in vitro results showing that even though HA can target CD44 positive cancer cells, receptor mediated endocytosis could only occur by cleavage of high molecular weight HA with an ubiquitous enzyme, hyaluronidase (Hase) are presented.
Journal ArticleDOI
Image-guided and passively tumour-targeted polymeric nanomedicines for radiochemotherapy.
Twan Lammers,Twan Lammers,Vladimir Subr,Peter Peschke,Rainer Kühnlein,Wim E. Hennink,Karel Ulbrich,Fabian Kiessling,Melanie Heilmann,Jürgen Debus,Peter E. Huber,Gert Storm +11 more
TL;DR: Carrier-based radiochemotherapy is proposed as a novel concept for treating advanced solid malignancies using N-(2-hydroxypropyl)methacrylamide andHPMA copolymers as model drugs and shown to interact synergistically with radiotherapy.
References
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Journal Article
A New Concept for Macromolecular Therapeutics in Cancer Chemotherapy: Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs
Yasuhiro Matsumura,Hiroshi Maeda +1 more
TL;DR: It is speculated that the tumoritropic accumulation of smancs and other proteins resulted because of the hypervasculature, an enhanced permeability to even macromolecules, and little recovery through either blood vessels or lymphatic vessels in tumors of tumor-bearing mice.
Journal ArticleDOI
Vascular endothelial growth factor is a secreted angiogenic mitogen
TL;DR: DNA sequencing suggests the existence of several molecular species of VEGF, a heparin-binding growth factor specific for vascular endothelial cells that is able to induce angiogenesis in vivo.
Journal ArticleDOI
Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid.
Donald R. Senger,Stephen J. Galli,Ann M. Dvorak,Carole A. Perruzzi,V. Susan Harvey,Harold F. Dvorak +5 more
TL;DR: Tumor ascites fluids from guinea pigs, hamsters, and mice contain activity that rapidly increases microvascular permeability, and this activity is secreted by these tumor cells and a variety of other tumor cell lines in vitro.
Journal Article
Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis.
TL;DR: T tumors have "borrowed" fundamental mechanisms that developed in multicellular organisms for purposes of tissue defense, renewal, and repair and taught us something new about angiogenesis, namely, that vascular hyperpermeability and consequent plasma protein extravasation are important, perhaps essential, elements in its generation.
Journal ArticleDOI
Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells.
TL;DR: Both short- and long-term exposure of human EC to VEGF stimulates the release of biologically active NO, suggesting that NO mediates aspects of V EGF signaling required for EC proliferation and organization in vitro.
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Yasuhiro Matsumura,Hiroshi Maeda +1 more