Journal ArticleDOI
Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review.
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TLDR
The basic characteristics of the EPR effect, particularly the factors involved, are described, as well as its modulation for improving delivery of macromolecular drugs to the tumor.About:
This article is published in Journal of Controlled Release.The article was published on 2000-03-01. It has received 5955 citations till now. The article focuses on the topics: Enhanced permeability and retention effect & Vascular permeability.read more
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An overview of clinical and commercial impact of drug delivery systems
TL;DR: These examples provide strong evidence of the clinical and commercial impact of drug delivery systems, which have impacted treatment of many prevalent diseases including diabetes, cancer and cardiovascular diseases, among others.
Journal ArticleDOI
Recent advances in polymeric micelles for anti-cancer drug delivery
TL;DR: Block co-polymeric micelles receive increased attention due to their ability to load therapeutics, deliver the cargo to the site of action, improve the pharmacokinetic of the loaded drug and reduce off-target cytotoxicity.
Journal ArticleDOI
Nanotheranostics and image-guided drug delivery: current concepts and future directions.
TL;DR: Nanotheranostic systems are considered to be highly suitable systems for (pre-) clinical implementation, not only because they might assist in better understanding various important aspects of the drug delivery process, and in developing better drug delivery systems, but also because they Might contribute to realizing the potential of "personalized medicine", and to developing more effective and less toxic treatment regimens for individual patients.
Journal ArticleDOI
Far-Red and Near-IR AIE-Active Fluorescent Organic Nanoprobes with Enhanced Tumor-Targeting Efficacy: Shape-Specific Effects.
Andong Shao,Yongshu Xie,Shaojia Zhu,Zhiqian Guo,Shiqin Zhu,Jin Guo,Ping Shi,Tony D. James,He Tian,Weihong Zhu +9 more
TL;DR: A unique molecular design strategy is presented that involves tailoring aggregation-induced emission (AIE)-active organic molecules to realize preferable far-red and NIR fluorescence, well-controlled morphology (from rod-like to spherical), and also tumor-targeted bioimaging.
Journal ArticleDOI
Reversible Cell‐Specific Drug Delivery with Aptamer‐Functionalized Liposomes
TL;DR: A controlled formulation of aptamerconjugated, cisplatin-encapsulating multifunctional liposomes is reported, which shows for the first time that a complementary DNA (cDNA) and liposome-based system based on EPR still has undesirable systemic side effects and suboptimal antitumor efficacy.
References
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Journal Article
A New Concept for Macromolecular Therapeutics in Cancer Chemotherapy: Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs
Yasuhiro Matsumura,Hiroshi Maeda +1 more
TL;DR: It is speculated that the tumoritropic accumulation of smancs and other proteins resulted because of the hypervasculature, an enhanced permeability to even macromolecules, and little recovery through either blood vessels or lymphatic vessels in tumors of tumor-bearing mice.
Journal ArticleDOI
Vascular endothelial growth factor is a secreted angiogenic mitogen
TL;DR: DNA sequencing suggests the existence of several molecular species of VEGF, a heparin-binding growth factor specific for vascular endothelial cells that is able to induce angiogenesis in vivo.
Journal ArticleDOI
Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid.
Donald R. Senger,Stephen J. Galli,Ann M. Dvorak,Carole A. Perruzzi,V. Susan Harvey,Harold F. Dvorak +5 more
TL;DR: Tumor ascites fluids from guinea pigs, hamsters, and mice contain activity that rapidly increases microvascular permeability, and this activity is secreted by these tumor cells and a variety of other tumor cell lines in vitro.
Journal Article
Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis.
TL;DR: T tumors have "borrowed" fundamental mechanisms that developed in multicellular organisms for purposes of tissue defense, renewal, and repair and taught us something new about angiogenesis, namely, that vascular hyperpermeability and consequent plasma protein extravasation are important, perhaps essential, elements in its generation.
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Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells.
TL;DR: Both short- and long-term exposure of human EC to VEGF stimulates the release of biologically active NO, suggesting that NO mediates aspects of V EGF signaling required for EC proliferation and organization in vitro.
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A New Concept for Macromolecular Therapeutics in Cancer Chemotherapy: Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs
Yasuhiro Matsumura,Hiroshi Maeda +1 more