Journal ArticleDOI
Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review.
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TLDR
The basic characteristics of the EPR effect, particularly the factors involved, are described, as well as its modulation for improving delivery of macromolecular drugs to the tumor.About:
This article is published in Journal of Controlled Release.The article was published on 2000-03-01. It has received 5955 citations till now. The article focuses on the topics: Enhanced permeability and retention effect & Vascular permeability.read more
Citations
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Journal ArticleDOI
Drug delivery and transport to solid tumors.
TL;DR: The effectiveness of cancer therapy depends in part on adequate delivery of the therapeutic agents to tumor cells, and a better understanding of the processes and contribution of these factors governing drug delivery may lead to new cancer therapeutic strategies.
Journal ArticleDOI
Self-Cross-Linked Polymer Nanogels: A Versatile Nanoscopic Drug Delivery Platform
Ja-Hyoung Ryu,Reuben T. Chacko,Siriporn Jiwpanich,Sean Bickerton,R. Prakash Babu,Sankaran Thayumanavan +5 more
TL;DR: Highly stable polymeric nanogels are synthesized, in which the kinetics of guest molecule release can be fine-tuned by control over cross-linking density, and it is shown that the noncovalently encapsulated guest molecules can be released in response to a redox trigger, glutathione (GSH).
Journal ArticleDOI
Magnetite nanoparticles for cancer diagnosis, treatment, and treatment monitoring: recent advances.
Richard A. Revia,Miqin Zhang +1 more
TL;DR: Recent applications of magnetite NPs in diagnosis, treatment, and treatment monitoring of cancer are addressed and some views will be discussed concerning the toxicity and clinical translation of iron oxide NPs.
Journal ArticleDOI
Lipid nanocapsules: A new platform for nanomedicine
TL;DR: These new nano-cargos have the ability to encapsulate efficiently lipophilic drugs, offering a pharmaceutical solution for their intravenous administration and should reduce considerably the cost and convenience for treatment.
Journal ArticleDOI
Drug delivery by supramolecular design
Matthew J. Webber,Robert Langer +1 more
TL;DR: In the context of clinical translation, features of supramolecular design may prove additionally advantageous, specifically in enabling quantitative drug loading, molecularly discrete delivery devices, and a priori knowledge of carrier degradation and clearance mechanisms.
References
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Journal Article
A New Concept for Macromolecular Therapeutics in Cancer Chemotherapy: Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs
Yasuhiro Matsumura,Hiroshi Maeda +1 more
TL;DR: It is speculated that the tumoritropic accumulation of smancs and other proteins resulted because of the hypervasculature, an enhanced permeability to even macromolecules, and little recovery through either blood vessels or lymphatic vessels in tumors of tumor-bearing mice.
Journal ArticleDOI
Vascular endothelial growth factor is a secreted angiogenic mitogen
TL;DR: DNA sequencing suggests the existence of several molecular species of VEGF, a heparin-binding growth factor specific for vascular endothelial cells that is able to induce angiogenesis in vivo.
Journal ArticleDOI
Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid.
Donald R. Senger,Stephen J. Galli,Ann M. Dvorak,Carole A. Perruzzi,V. Susan Harvey,Harold F. Dvorak +5 more
TL;DR: Tumor ascites fluids from guinea pigs, hamsters, and mice contain activity that rapidly increases microvascular permeability, and this activity is secreted by these tumor cells and a variety of other tumor cell lines in vitro.
Journal Article
Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis.
TL;DR: T tumors have "borrowed" fundamental mechanisms that developed in multicellular organisms for purposes of tissue defense, renewal, and repair and taught us something new about angiogenesis, namely, that vascular hyperpermeability and consequent plasma protein extravasation are important, perhaps essential, elements in its generation.
Journal ArticleDOI
Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells.
TL;DR: Both short- and long-term exposure of human EC to VEGF stimulates the release of biologically active NO, suggesting that NO mediates aspects of V EGF signaling required for EC proliferation and organization in vitro.
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A New Concept for Macromolecular Therapeutics in Cancer Chemotherapy: Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs
Yasuhiro Matsumura,Hiroshi Maeda +1 more