Journal ArticleDOI
Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review.
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TLDR
The basic characteristics of the EPR effect, particularly the factors involved, are described, as well as its modulation for improving delivery of macromolecular drugs to the tumor.About:
This article is published in Journal of Controlled Release.The article was published on 2000-03-01. It has received 5955 citations till now. The article focuses on the topics: Enhanced permeability and retention effect & Vascular permeability.read more
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Clinically-translated silica nanoparticles as dual-modality cancer-targeted probes for image-guided surgery and interventions
Michelle S. Bradbury,Evan H. Phillips,Pablo H. Montero,Sarah M. Cheal,Hilda Stambuk,Jeremy C. Durack,Constantinos T. Sofocleous,Richard J. C. Meester,Ulrich Wiesner,Snehal G. Patel +9 more
TL;DR: A clinically-translated, integrin-targeting platform for use with both PET and optical imaging that meets a number of key design criteria for improving SLN tissue localization and retention, target-to-background ratios, and clearance from the site of injection and the body is described.
Journal ArticleDOI
Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs: part 3. Therapeutic efficacy and safety studies in ovarian cancer xenograft model
Harikrishna Devalapally,Dinesh Shenoy,Dinesh Shenoy,Steven R. Little,Steven R. Little,Robert Langer,Mansoor M. Amiji +6 more
TL;DR: PEO-modified PbAE nanoparticles are a unique pH-sensitive drug delivery system that elicits enhanced efficacy and safety profile in solid tumor therapy and show improved therapeutic efficacy as compared to the paclitaxel aqueous solution.
Journal ArticleDOI
The rise and rise of stealth nanocarriers for cancer therapy: passive versus active targeting
TL;DR: The clinical trials on patients with solid tumors and the benefits of passive targeting for drug delivery to the solid tumors via the enhanced permeability and retention effect, when using stealth nanoparticles, are described and compared with the advantages of active targeting.
Journal ArticleDOI
Targeted gold nanoparticles enhance sensitization of prostate tumors to megavoltage radiation therapy in vivo
Tatiana Wolfe,Dev K. Chatterjee,Jihyoun Lee,Jonathan D. Grant,Shanta Raj Bhattarai,Ramesh C. Tailor,Glenn P. Goodrich,Patrícia Nicolucci,Sunil Krishnan +8 more
TL;DR: In this article, the authors used goserelin-conjugated gold nanorods for radiosensitization of prostate cancers in vitro and in vivo, and showed that the high concentrations of gold required, the long interval between injection of nanoparticles and radiation, and the use of megavoltage radiation to generate radiosenseitization in vivo foretell the possibility of eventual clinical translation of this approach.
References
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Journal Article
A New Concept for Macromolecular Therapeutics in Cancer Chemotherapy: Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs
Yasuhiro Matsumura,Hiroshi Maeda +1 more
TL;DR: It is speculated that the tumoritropic accumulation of smancs and other proteins resulted because of the hypervasculature, an enhanced permeability to even macromolecules, and little recovery through either blood vessels or lymphatic vessels in tumors of tumor-bearing mice.
Journal ArticleDOI
Vascular endothelial growth factor is a secreted angiogenic mitogen
TL;DR: DNA sequencing suggests the existence of several molecular species of VEGF, a heparin-binding growth factor specific for vascular endothelial cells that is able to induce angiogenesis in vivo.
Journal ArticleDOI
Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid.
Donald R. Senger,Stephen J. Galli,Ann M. Dvorak,Carole A. Perruzzi,V. Susan Harvey,Harold F. Dvorak +5 more
TL;DR: Tumor ascites fluids from guinea pigs, hamsters, and mice contain activity that rapidly increases microvascular permeability, and this activity is secreted by these tumor cells and a variety of other tumor cell lines in vitro.
Journal Article
Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis.
TL;DR: T tumors have "borrowed" fundamental mechanisms that developed in multicellular organisms for purposes of tissue defense, renewal, and repair and taught us something new about angiogenesis, namely, that vascular hyperpermeability and consequent plasma protein extravasation are important, perhaps essential, elements in its generation.
Journal ArticleDOI
Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells.
TL;DR: Both short- and long-term exposure of human EC to VEGF stimulates the release of biologically active NO, suggesting that NO mediates aspects of V EGF signaling required for EC proliferation and organization in vitro.
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