Journal ArticleDOI
Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review.
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TLDR
The basic characteristics of the EPR effect, particularly the factors involved, are described, as well as its modulation for improving delivery of macromolecular drugs to the tumor.About:
This article is published in Journal of Controlled Release.The article was published on 2000-03-01. It has received 5955 citations till now. The article focuses on the topics: Enhanced permeability and retention effect & Vascular permeability.read more
Citations
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Synthesis and biological response of size-specific, monodisperse drug-silica nanoconjugates
TL;DR: 20 nm NCs are superior to their 50 and 200 nm NC analogues by 2-5- and 10-20-fold, respectively, with regard to tumor accumulation and penetration and cellular internalization, which underscores the importance and necessity of further miniaturizing nanomedicine size for optimized drug delivery applications.
Journal ArticleDOI
Extravasation of polymeric nanomedicines across tumor vasculature
TL;DR: This review highlights the current knowledge on the distinct tumor microenvironment generated barriers which limit extravasation of drugs and focuses on modalities for overcoming these barriers using multi-functional polymeric carriers.
Journal ArticleDOI
On the near-wall accumulation of injectable particles in the microcirculation: smaller is not better
Tae-Rin Lee,Myunghwan Choi,Adrian M. Kopacz,Seok Hyun Yun,Wing Kam Liu,Wing Kam Liu,Wing Kam Liu,Paolo Decuzzi +7 more
TL;DR: The vascular distribution of spherical particles, from 10 to 1,000 nm in diameter, is studied using intravital microscopy and computational modeling, suggesting that sub-micron particles could deposit within diseased vascular districts more efficiently than conventional nanoparticles.
Journal ArticleDOI
Magnetic and fluorescent nanoparticles for multimodality imaging
Willem J. M. Mulder,Arjan W. Griffioen,Gustav J. Strijkers,David P. Cormode,Klaas Nicolay,Zahi A. Fayad +5 more
TL;DR: This review gives a survey of the different types of fluorescent and magnetic nanoparticles that have been employed for both magnetic resonance and optical imaging studies.
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Nanostructured materials functionalized with metal complexes: In search of alternatives for administering anticancer metallodrugs
TL;DR: The state-of-art of nanostructured materials functionalized with metallodrugs as anticancer agents is described in this review, and the functionalization of several classes of metal complexes including platinum and non-platinum compounds is also addressed.
References
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Journal Article
A New Concept for Macromolecular Therapeutics in Cancer Chemotherapy: Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs
Yasuhiro Matsumura,Hiroshi Maeda +1 more
TL;DR: It is speculated that the tumoritropic accumulation of smancs and other proteins resulted because of the hypervasculature, an enhanced permeability to even macromolecules, and little recovery through either blood vessels or lymphatic vessels in tumors of tumor-bearing mice.
Journal ArticleDOI
Vascular endothelial growth factor is a secreted angiogenic mitogen
TL;DR: DNA sequencing suggests the existence of several molecular species of VEGF, a heparin-binding growth factor specific for vascular endothelial cells that is able to induce angiogenesis in vivo.
Journal ArticleDOI
Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid.
Donald R. Senger,Stephen J. Galli,Ann M. Dvorak,Carole A. Perruzzi,V. Susan Harvey,Harold F. Dvorak +5 more
TL;DR: Tumor ascites fluids from guinea pigs, hamsters, and mice contain activity that rapidly increases microvascular permeability, and this activity is secreted by these tumor cells and a variety of other tumor cell lines in vitro.
Journal Article
Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis.
TL;DR: T tumors have "borrowed" fundamental mechanisms that developed in multicellular organisms for purposes of tissue defense, renewal, and repair and taught us something new about angiogenesis, namely, that vascular hyperpermeability and consequent plasma protein extravasation are important, perhaps essential, elements in its generation.
Journal ArticleDOI
Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells.
TL;DR: Both short- and long-term exposure of human EC to VEGF stimulates the release of biologically active NO, suggesting that NO mediates aspects of V EGF signaling required for EC proliferation and organization in vitro.
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