Variants of β-casofensin, a bioactive milk peptide, differently modulate the intestinal barrier: In vivo and ex vivo studies in rats.
Jérémie Bruno,Aurélie Nicolas,Sandra Pesenti,Jessica Schwarz,Jean-Luc Simon,Joëlle Léonil,Pascale Plaisancié +6 more
TLDR
The substitution of a single amino acid alters the effect of β-CN sequence f94 to 123 on goblet cells and on intestinal permeability and a genetic polymorphism ofβ-CN can affect the biological activity of peptides derived from this protein.About:
This article is published in Journal of Dairy Science.The article was published on 2017-05-01 and is currently open access. It has received 12 citations till now. The article focuses on the topics: Ussing chamber & Mucin 2.read more
Citations
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Application of in silico approaches for the generation of milk protein-derived bioactive peptides
Richard J. FitzGerald,Maria Cermeño,Mohammadreza Khalesi,Thanyaporn Kleekayai,Miryam Amigo-Benavent +4 more
TL;DR: The generation of potent and effective health enhancing hydrolysates/peptides can benefit from a range of in silico techniques including the application of structure bioactivity relationship modelling, molecular docking and design of experiments (DOE) approaches to optimise BAP production and identification.
Journal ArticleDOI
Characterization of Mucus-Related Properties of Streptococcus thermophilus: From Adhesion to Induction
Neïké Fernandez,Laura Wrzosek,Joanna M. Radziwill-Bienkowska,Belinda Ringot-Destrez,Belinda Ringot-Destrez,Marie-Pierre Duviau,Marie-Louise Noordine,Valérie Laroute,Véronique Robert,Claire Cherbuy,Marie-Line Daveran-Mingot,Muriel Cocaign-Bousquet,Renaud Léonard,Renaud Léonard,Catherine Robbe-Masselot,Catherine Robbe-Masselot,Françoise Rul,Eric Ogier-Denis,Eric Ogier-Denis,Eric Ogier-Denis,Muriel Thomas,Muriel Mercier-Bonin +21 more
TL;DR: It is shown that although S. thermophilus is a poor mucus-adhesive bacterium, it can promote mucus pathway at least in part by producing lactate in the digestive tract.
Journal ArticleDOI
Genetic potential of Sindhi cattle for A2 milk production
Gustavo Pimenta Schettini,Sabrina Mota Lambert,Bárbara Maria Paraná da Silva Souza,Raphael Bermal Costa,Gregório Miguel Ferreira de Camargo +4 more
TL;DR: The high frequency of the A2A2 genotype in Sindhi cattle indicates a genetic potential of the breed for A2 milk production and easy, assisted selection (if that is the intention).
Journal ArticleDOI
Effect of caseinate glycation with oligochitosan and transglutaminase on the intestinal barrier function of the tryptic caseinate digest in IEC-6 cells.
Jia Shi,Xin-Huai Zhao +1 more
TL;DR: It is highlighted that the used TGase-type glycation endowed the oligochitosan-glycated caseinate with a potential functional food ingredient to strengthen the epithelial barrier function, which might be a helpful event to intestinal health.
Journal ArticleDOI
Review: The effect of casein genetic variants, glycosylation and phosphorylation on bovine milk protein structure, technological properties, nutrition and product manufacture
TL;DR: In this paper , the influence of casein genetic variants, phosphorylation and glycosylation modifications on the compositional and functional properties of milk is not yet fully elucidated, and the properties of certain casein variants associate with human nutrition and the physicochemical and sensory characteristics of dairy products.
References
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VMD: Visual molecular dynamics
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Electrostatics of nanosystems: Application to microtubules and the ribosome
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PDB2PQR: an automated pipeline for the setup of Poisson–Boltzmann electrostatics calculations
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PDB2PQR: expanding and upgrading automated preparation of biomolecular structures for molecular simulations
Todd J. Dolinsky,Paul Czodrowski,Hui Li,Jens Erik Nielsen,Jan H. Jensen,Gerhard Klebe,Nathan A. Baker +6 more
TL;DR: The significantly expanded PDB2PQR is reported that includes robust standalone command line support, improved pKa estimation via the PROPKA framework, ligand parameterization via PEOE_PB charge methodology, expanded set of force fields and easily incorporated user-defined parameters via XML input files, and improvement of atom addition and optimization code.
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Nomenclature of the Proteins of Cows’ Milk—Sixth Revision
Harold M. Farrell,Rafael Jiménez-Flores,Gregory T. Bleck,E. M. Brown,J. E. Butler,Lawrence K. Creamer,C.L. Hicks,C.M. Hollar,K.F. Ng-Kwai-Hang,Harold E. Swaisgood +9 more
TL;DR: Significant findings related to nomenclature and protein methodology are elucidation of several new genetic variants of the major milk proteins, establishment by sequencing techniques and sequence alignment of the bovine caseins and whey proteins as the reference point for the nomenClature of all homologous milk proteins.
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Paracellular transport of a proteolytically labile pentapeptide across the colonic and other intestinal segments of the albino rabbit: implications for peptide drug design
Yen Wan-Ching,Vincent H.L. Lee +1 more