Journal ArticleDOI
Whole-genome sequencing of 234 bulls facilitates mapping of monogenic and complex traits in cattle
Hans D. Daetwyler,Aurélien Capitan,Hubert Pausch,Paul Stothard,Rianne van Binsbergen,R.F. Brøndum,Xiaoping Liao,Anis Djari,Sabrina Rodriguez,Cécile Grohs,Diane Esquerre,Olivier Bouchez,Marie-Noelle Rossignol,Christophe Klopp,Dominique Rocha,Sébastien Fritz,André Eggen,Phil J. Bowman,David Coote,Amanda J. Chamberlain,Charlotte Anderson,Curt P VanTassell,Ina Hulsegge,Michael E. Goddard,Bernt Guldbrandtsen,M.S. Lund,Roel F. Veerkamp,Didier Boichard,Ruedi Fries,Ben J. Hayes +29 more
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TLDR
The 1000 bull genomes project supports the goal of accelerating the rates of genetic gain in domestic cattle while at the same time considering animal health and welfare by providing the annotated sequence variants and genotypes of key ancestor bulls.Abstract:
The 1000 bull genomes project supports the goal of accelerating the rates of genetic gain in domestic cattle while at the same time considering animal health and welfare by providing the annotated sequence variants and genotypes of key ancestor bulls. In the first phase of the 1000 bull genomes project, we sequenced the whole genomes of 234 cattle to an average of 8.3-fold coverage. This sequencing includes data for 129 individuals from the global Holstein-Friesian population, 43 individuals from the Fleckvieh breed and 15 individuals from the Jersey breed. We identified a total of 28.3 million variants, with an average of 1.44 heterozygous sites per kilobase for each individual. We demonstrate the use of this database in identifying a recessive mutation underlying embryonic death and a dominant mutation underlying lethal chrondrodysplasia. We also performed genome-wide association studies for milk production and curly coat, using imputed sequence variants, and identified variants associated with these traits in cattle.read more
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Journal ArticleDOI
Identification of bovine CpG SNPs as potential targets for epigenetic regulation via DNA methylation.
Mariângela Bueno Cordeiro Maldonado,Nelson B. de Rezende Neto,Sheila Tiemi Nagamatsu,Marcelo Falsarella Carazzolle,Jesse L. Hoff,Lynsey K. Whitacre,Robert D. Schnabel,Susanta K. Behura,Stephanie D. McKay,Jeremy F. Taylor,Flavia L. Lopes +10 more
TL;DR: The methyl SNP database (dbmeSNP) is useful for identifying potentially functional "epigenetic polymorphisms" underlying variation in bovine phenotypes.
Journal ArticleDOI
Sequence-based GWAS and post-GWAS analyses reveal a key role of SLC37A1, ANKH, and regulatory regions on bovine milk mineral content.
Marie Pierre Sanchez,Dominique Rocha,Mathieu Charles,Mekki Boussaha,Chris Hozé,Mickael Brochard,Agnès Delacroix-Buchet,Philippe Grosperrin,Didier Boichard +8 more
TL;DR: In this paper, the authors used 1 million test-day predictions of Ca, Mg, P, K, Na, and citrate content from 126,876 Montbeliarde cows, of which 19,586 had genotype data available.
Journal ArticleDOI
Sustainable Intensification of Beef Production in the Tropics: The Role of Genetically Improving Sexual Precocity of Heifers
Gerardo Alves Fernandes Júnior,Delvan Alves da Silva,Lúcio Flávio Macedo Mota,Thaise Pinto de Melo,Larissa Fernanda Simielli Fonseca,Danielly Beraldo dos Santos Silva,Roberto Carvalheiro,Lucia Galvão de Albuquerque +7 more
TL;DR: In 12 years of selection for female early precocity and improved management practices, the phenotypic means of age at first calving showed a strong decreasing trend, changing from nearly 34 to less than 28 months, with a genetic trend of almost -2 days/year.
Journal ArticleDOI
Mandibulofacial dysostosis attributed to a recessive mutation of CYP26C1 in hereford cattle
Renae L Sieck,Anna M Fuller,Patrick S. Bedwell,Jack A. Ward,S Sanders,Shi Hua Xiang,Sichong Peng,Jessica L. Petersen,David J. Steffen +8 more
TL;DR: It is postulate that this recessive missense mutation in CYP26C1 impacts the catalytic activity of the encoded enzyme, leading to excess RA resulting in the observed MD phenotype.
Journal ArticleDOI
GWAS and genomic prediction of milk urea nitrogen in Australian and New Zealand dairy cattle
I. van den Berg,P.N. Ho,Thuan Nguyen,Mekonnen Haile-Mariam,Iona M. MacLeod,Phil R. Beatson,Erin O’Connor,Jennie E. Pryce +7 more
TL;DR: In this article , the authors performed within-country GWAS and a meta-GWAS for MUN using records from up to 33,873 dairy cows and imputed whole-genome sequence data, to compare QTL detected in the GWAS for milk urea nitrogen (MUN) in AUS and New Zealand (NZL).
References
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Journal ArticleDOI
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