Journal ArticleDOI
Wild mice: an ever-increasing contribution to a popular mammalian model.
TLDR
This article provides examples with the aim of promoting the use of new strains belonging to different species of Mus established from wild progenitors, helpful for making genome annotations because they permit highly refined genotype-phenotype correlations.About:
This article is published in Trends in Genetics.The article was published on 2003-01-01. It has received 315 citations till now.read more
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Subspecific origin and haplotype diversity in the laboratory mouse
Hyuna Yang,Jeremy Wang,John P. Didion,Ryan J. Buus,Timothy A. Bell,Catherine E. Welsh,Franãois Bonhomme,Alex Hon Tsen Yu,Michael W. Nachman,Jaroslav Piálek,Priscilla K. Tucker,Pierre Boursot,Leonard McMillan,Gary A. Churchill,Fernando Pardo-Manuel de Villena +14 more
TL;DR: A genome-wide, high-resolution map of the phylogenetic origin of the genome of most extant laboratory mouse inbred strains is provided, based on the genotypes of wild-caught mice from three subspecies of Mus musculus.
Journal ArticleDOI
Mx GTPases: dynamin-like antiviral machines of innate immunity
TL;DR: New structural and functional insights are focused on and recent data revealing that human MxA (MX1) provides a safeguard against introduction of avian influenza A viruses into the human population is discussed.
Journal ArticleDOI
Molecular Organization of Vomeronasal Chemoreception
Yoh Isogai,Sheng Si,Lorena Pont-Lezica,Lorena Pont-Lezica,Taralyn Tan,Vikrant Kapoor,Venkatesh N. Murthy,Catherine Dulac,Catherine Dulac +8 more
TL;DR: It is demonstrated that the two classes (V1R and V2R) of vomeronasal receptors use fundamentally different strategies to encode chemosensory information, and that distinct receptor subfamilies have evolved towards the specific recognition of certain animal groups or chemical structures.
Journal ArticleDOI
Physiological insights into all-trans-retinoic acid biosynthesis
TL;DR: Cumulative data support a model of interactions among these enzymes with retinoid binding-proteins, with feedback regulation and/or control by atRA via modulating gene expression of multiple participants, which indicates that physiological atRA biosynthesis occurs via a regulated process.
Journal ArticleDOI
The human model: a genetic dissection of immunity to infection in natural conditions.
TL;DR: The human model is an indispensable complement to animal models, as it allows an observational genetic dissection of immunity to infection.
References
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Journal Article
Construction of a genetic linkage map in man using restriction fragment length polymorphisms.
TL;DR: A new basis for the construction of a genetic linkage map of the human genome is described, to develop, by recombinant DNA techniques, random single-copy DNA probes capable of detecting DNA sequence polymorphisms, when hybridized to restriction digests of an individual's DNA.
Book
Genetic variants and strains of the laboratory mouse
Mary F. Lyon,Antony G. Searle +1 more
TL;DR: Rules and guidelines for gene nomenclature, Mary F.Lyon catalogue of mutant genes and polymorphic loci, Margaret C. Green retroviral and cancer-related genes, Christine A.Reiner DNA polymorphisms, Rosemary W.Elliott highly repeated DNA families in the genome of "mus-musculus".
Journal ArticleDOI
Intra- and interspecific variation in primate gene expression patterns
Wolfgang Enard,Philipp Khaitovich,Joachim Klose,Sebastian Zöllner,Florian Heissig,Patrick Giavalisco,Kay Nieselt-Struwe,Elaine A. Muchmore,Elaine A. Muchmore,Ajit Varki,Rivka Ravid,Gaby G. M. Doxiadis,Ronald E. Bontrop,Svante Pääbo +13 more
TL;DR: Three mouse species that are approximately as related to each other as are humans, chimpanzees, and orangutans are studied, and species-specific gene expression patterns indicating that changes in protein and gene expression have been particularly pronounced in the human brain are identified.
Journal ArticleDOI
Genealogies of mouse inbred strains.
Jon A. Beck,S E Lloyd,Majid Hafezparast,Moyha Lennon-Pierce,Janan T. Eppig,Michael F. W. Festing,Elizabeth M. C. Fisher +6 more
TL;DR: It is proposed that all genealogical and genetic data on inbred strains be submitted to a common electronic database to ensure this valuable information resource is preserved and used efficiently.
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