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World malaria report
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The article was published on 2005-01-01 and is currently open access. It has received 5145 citations till now. The article focuses on the topics: Malaria & Indoor residual spraying.read more
Citations
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Hemoglobinopathies: Slicing the Gordian Knot of Plasmodium falciparum Malaria Pathogenesis
TL;DR: Hemoglobinopathies slice the “Gordian knot” of host and parasite interactions to confer malaria protection, and offer a translational model to identify the most critical mechanisms of P. falciparum pathogenesis.
Genetic Investigation of Tricarboxylic Acid Metabolism during the Plasmodium falciparum Life Cycle
Hangjun Ke,Ian A. Lewis,Joanne M. Morrisey,Kyle Jarrod McLean,Heather J. Painter,Michael W. Mather,Marcelo Jacobs-Lorena,Akhil B. Vaidya,Suresh M. Ganesan,Manuel Llinás +9 more
TL;DR: In this paper, the authors describe 11 genetic knockout (KO) lines that delete six of the eight mitochondrial tricarboxylic acid (TCA) cycle enzymes, and these metabolic deficiencies halted life-cycle progression in later stages.
Journal ArticleDOI
Differential transcriptome analysis of glandular and filamentous trichomes in Artemisia annua
Sandra Soetaert,Christophe Van Neste,Mado Vandewoestyne,Steven R. Head,Alain Goossens,Filip Van Nieuwerburgh,Dieter Deforce +6 more
TL;DR: A comparison of the transcriptome from glandular and filamentous trichomes shows that MEP, MVA, most terpene and lipid biosynthesis pathways are significantly upregulated in glandular trichome, while some transcripts coding for specific sesquiterpenoids and triterpenoid enzymes were significantly up regulated in filamentoustrichomes.
Journal ArticleDOI
A phase 1 trial of MSP2-C1, a blood-stage malaria vaccine containing 2 isoforms of MSP2 formulated with Montanide® ISA 720.
James S. McCarthy,Joanne Marjason,Suzanne L. Elliott,Paul Fahey,Gilles Bang,Elissa Malkin,Eveline L. Tierney,Hayley Aked-Hurditch,Christopher G. Adda,Nadia Cross,Jack S. Richards,Freya J. I. Fowkes,Michelle J. Boyle,Carole A. Long,Pierre Druilhe,James G. Beeson,Robin F. Anders +16 more
TL;DR: Although the induced anti-MSP2 antibodies did not directly inhibit parasite growth in vitro, IgG from the majority of individuals tested caused significant antibody-dependent cellular inhibition (ADCI) of parasite growth, in view of the reactogenicity of this formulation, further clinical development of M SP2-C1 will require formulation of MSP2 in an alternative adjuvant.
Journal ArticleDOI
Epidemiology of Disappearing Plasmodium vivax Malaria: A Case Study in Rural Amazonia
Susana Barbosa,Amanda B. Gozze,Nathália F. Lima,Camilla L. Batista,Melissa S. Bastos,Vanessa C. Nicolete,Pablo S. Fontoura,Raquel Gonçalves,Susana Ariane S. Viana,Maria José Menezes,Kézia K. G. Scopel,Carlos Eugênio Cavasini,Rosely dos Santos Malafronte,Mônica da Silva-Nunes,Joseph M. Vinetz,Marcia C. Castro,Marcelo U. Ferreira +16 more
TL;DR: The relative contribution of low-density and asymptomatic parasitemias to the overall Plasmodium vivax burden over a period of declining transmission is examined and potential hurdles for malaria elimination in Remansinho and similar settings are discussed.
References
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The Analysis and Display of Real Time Surface Climate Data
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Malaria mortality rates in South Asia and in Africa: implications for malaria control.
TL;DR: This work examines malaria-related mortality under different circumstances and discusses implications for the management of malaria in these settings and emphasizes the power of rapid case treatment to save lives at risk under virtually all circumstances of malaria transmission.
Journal Article
Epidemiology of malaria in displaced Khmers on the Thai-Kampuchean border.
TL;DR: Malaria epidemiology from 1983 to 1985 in displaced Khmers living in camps on the Thai-Kampuchean border was studied and Epidemiological information has been more useful for planning than for evaluating control measures.
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