Zika Virus Infection during Pregnancy in Mice Causes Placental Damage and Fetal Demise.
Jonathan J. Miner,Bin Cao,Jennifer Govero,Amber M. Smith,Estefania Fernandez,Omar H. Cabrera,Charise Garber,Michelle Noll,Robyn S. Klein,Kevin K. Noguchi,Indira U. Mysorekar,Michael S. Diamond +11 more
TLDR
These models will facilitate the study of ZIKV pathogenesis, in utero transmission, and testing of therapies and vaccines to prevent congenital malformations and to identify ZikV within trophoblasts of the maternal and fetal placenta, consistent with a trans-placental infection route.About:
This article is published in Cell.The article was published on 2016-05-19 and is currently open access. It has received 713 citations till now. The article focuses on the topics: Fetal disease & Fetus.read more
Citations
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Dengue virus sero-cross-reactivity drives antibody-dependent enhancement of infection with zika virus
Wanwisa Dejnirattisai,Piyada Supasa,Piyada Supasa,Wiyada Wongwiwat,Alexander Rouvinski,Giovanna Barba-Spaeth,Giovanna Barba-Spaeth,Thaneeya Duangchinda,Anavaj Sakuntabhai,Anavaj Sakuntabhai,Van-Mai Cao-Lormeau,Prida Malasit,Prida Malasit,Félix A. Rey,Félix A. Rey,Juthathip Mongkolsapaya,Juthathip Mongkolsapaya,Gavin R. Screaton +17 more
TL;DR: Plasma immune to DENV showed substantial cross-reaction to ZIKV and was able to drive antibody-dependent enhancement (ADE) of ZikaV infection, indicating that immunity toDENV might drive greater ZikV replication and have clear implications for disease pathogenesis and future vaccine programs.
Journal ArticleDOI
Shared and Distinct Functions of Type I and Type III Interferons.
TL;DR: A model wherein type III IFNs serve as a front-line defense that controls infection at epithelial barriers while minimizing damaging inflammatory responses, reserving the more potent type I IFN response for when local responses are insufficient is discussed.
Journal ArticleDOI
Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen
Miao Xu,Emily M. Lee,Zhexing Wen,Yichen Cheng,Wei Kai Huang,Xuyu Qian,Julia Tcw,Jennifer Kouznetsova,Sarah C. Ogden,Christy Hammack,Fadi Jacob,Ha Nam Nguyen,Misha Itkin,Catherine Hanna,Paul Shinn,Chase Allen,Samuel G. Michael,Anton Simeonov,Wenwei Huang,Kimberly M. Christian,Alison Goate,Kristen J. Brennand,Ruili Huang,Menghang Xia,Guo Li Ming,Wei Zheng,Hongjun Song,Hengli Tang +27 more
TL;DR: A pan-caspase inhibitor, emricasan, inhibited ZIKV-induced increases in caspase-3 activity and protected human cortical neural progenitors in both monolayer and three-dimensional organoid cultures, and combination treatments using one compound from each category (neuroprotective and antiviral) further increased protection of human neural progensitors and astrocytes from ZIKv-induced cell death.
Journal ArticleDOI
Vaccine protection against Zika virus from Brazil
Rafael A. Larocca,Peter Abbink,Jean Pierre Schatzmann Peron,Paolo Marinho de Andrade Zanotto,M. Justin Iampietro,Alexander Badamchi-Zadeh,Michael R. Boyd,David Ng’ang’a,Marinela Kirilova,Ramya Nityanandam,Noe B. Mercado,Zhenfeng Li,Edward T. Moseley,Christine A. Bricault,Erica N. Borducchi,Patricia B. Giglio,David Jetton,George H. Neubauer,Joseph P. Nkolola,Lori F. Maxfield,Rafael De La Barrera,Richard G. Jarman,Kenneth H. Eckels,Nelson L. Michael,Stephen J. Thomas,Dan H. Barouch,Dan H. Barouch +26 more
TL;DR: It is demonstrated that protection against ZIKV challenge can be achieved by single-shot subunit and inactivated virus vaccines in mice and that Env-specific antibody titers represent key immunologic correlates of protection.
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An update on Zika virus infection
TL;DR: This Review focuses on important updates and gaps in the knowledge of Zika virus as of early 2017, which have been reported in continental USA, Africa, and southeast Asia.
References
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From the Centers for Disease Control and Prevention
TL;DR: This report summarizes the clinical features of these cases and the epidemiologic investigations by the Texas Department of Health and the New Jersey State Department of health and Senior Services, which indicated that a bat-associated variant of the rabies virus was responsible for infection in both cases.
Journal ArticleDOI
Zika Virus Associated with Microcephaly
Jernej Mlakar,Miša Korva,Mateja Poljšak-Prijatelj,Jerica Mraz,Marko Kolenc,Katarina Resman Rus,Tina Vesnaver Vipotnik,Vesna Fabjan,Alenka Vizjak,Miroslav Petrovec +9 more
TL;DR: The case of an expectant mother who had a febrile illness with rash at the end of the first trimester of pregnancy while she was living in Brazil and revealed microcephaly with calcifications in the fetal brain and placenta is described.
Journal ArticleDOI
Genetic and Serologic Properties of Zika Virus Associated with an Epidemic, Yap State, Micronesia, 2007
Robert S. Lanciotti,Olga Kosoy,Janeen Laven,Jason O. Velez,Amy J. Lambert,Alison J. Johnson,Stephanie M. Stanfield,Mark R. Duffy +7 more
TL;DR: The full coding region nucleic acid sequence and serologic properties of the virus were identified and the virus was identified as Crimean-Congo-Wales coronavirus.
Journal ArticleDOI
Zika Virus Infection in Pregnant Women in Rio de Janeiro - Preliminary Report.
Abstr Act,Patrícia Brasil,Jose Paulo Pereira,Claudia Raja Gabaglia,Luana Damasceno,Mayumi Duarte Wakimoto,Rita Maria Ribeiro Nogueira,Patricia Carvalho de Sequeira,André M. Siqueira,Liege Maria Abreu de Carvalho,Denise Cotrim da Cunha,Guilherme Amaral Calvet,Elizabeth de Souza Neves,Maria Elisabeth Lopes Moreira,Ana Elisa Rodrigues Baião,Paulo Roberto Nassar de Carvalho,Carla Janzen,Stephanie G. Valderramos,James D. Cherry,Ana Maria Bispo de Filippis,Karin Nielsen-Saines +20 more
TL;DR: Despite mild clinical symptoms in the mother, ZIKV infection during pregnancy is deleterious to the fetus and is associated with fetal death, fetal growth restriction, and a spectrum of central nervous system abnormalities.
Journal ArticleDOI
Zika Virus and Birth Defects — Reviewing the Evidence for Causality
TL;DR: It is concluded that a causal relationship exists between prenatal Zika virus infection and microcephaly and other serious brain anomalies and needs to intensify efforts toward the prevention of adverse outcomes caused by congenital Zika virus infections.
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