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Ajit Varki
Researcher at University of California, San Diego
Publications - 557
Citations - 63836
Ajit Varki is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Sialic acid & SIGLEC. The author has an hindex of 124, co-authored 542 publications receiving 58772 citations. Previous affiliations of Ajit Varki include Emory University & National Institute of Advanced Industrial Science and Technology.
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Journal ArticleDOI
Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin.
Emma Byres,Adrienne W. Paton,James C. Paton,Jonas Lofling,David F. Smith,Matthew C.J. Wilce,Ursula M. Talbot,Damien C. Chong,Hai Yu,Shengshu Huang,Xi Chen,Nissi Varki,Ajit Varki,Jamie Rossjohn,Travis Clarke Beddoe +14 more
TL;DR: It is shown that SubB has a strong preference for glycans terminating in the sialic acid N-glycolylneuraminic acid (Neu5Gc), a monosaccharide not synthesized in humans, which confers susceptibility to the gastrointestinal and systemic toxicities of SubAB.
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The selectin GMP-140 binds to sialylated, fucosylated lactosaminoglycans on both myeloid and nonmyeloid cells.
TL;DR: The sialyl Lewis x tetrasaccharide may require additional structural modifications or specific presentations in order for leukocytes in flowing blood to interact rapidly and with high affinity to GMP-140 on activated platelets or endothelium.
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Acidic pH increases airway surface liquid viscosity in cystic fibrosis
Xiao Xiao Tang,Lynda S. Ostedgaard,Mark J. Hoegger,Thomas O. Moninger,Philip H. Karp,James D. McMenimen,Biswa Choudhury,Ajit Varki,David A. Stoltz,Michael J. Welsh +9 more
TL;DR: Airway surface liquid collected from newborn piglets and ASL on cultured airway epithelia revealed that the viscosity of CF ASL was increased relative to that of non-CF ASL, suggesting that acidic pH influences mucin electrostatic interactions.
Journal ArticleDOI
The Sialome—Far More Than the Sum of Its Parts
Miriam Cohen,Ajit Varki +1 more
TL;DR: Five levels of complexity are reviewed and the experimental approaches used for analysis at each level are discussed for a subclass of the glycome: the sialome, which is far more than the sum of its parts.
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Calcium-dependent heparin-like ligands for L-selectin in nonlymphoid endothelial cells
TL;DR: Staining of cultured endothelial cells with an L-selectin chimera (LS-Rg) showed an internal pool of ligands, which could be physiological ligands mediating leucocyte trafficking.