A
Ajit Varki
Researcher at University of California, San Diego
Publications - 557
Citations - 63836
Ajit Varki is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Sialic acid & SIGLEC. The author has an hindex of 124, co-authored 542 publications receiving 58772 citations. Previous affiliations of Ajit Varki include Emory University & National Institute of Advanced Industrial Science and Technology.
Papers
More filters
Journal ArticleDOI
Uptake and incorporation of an epitope-tagged sialic acid donor into intact rat liver Golgi compartments. Functional localization of sialyltransferase overlaps with beta-galactosyltransferase but not with sialic acid O-acetyltransferase.
Roger Chammas,J M McCaffery,Andre Klein,Y Ito,Lucian Saucan,G E Palade,Marilyn G. Farquhar,Ajit Varki +7 more
TL;DR: 9-O-acetylation occurs after the last point of Sia addition in the trans-Golgi network, and is shown to be preferentially segregated into a subset of vesicular carriers that concentrate membrane-bound, but not secretory, proteins.
Patent
Heparin Compositions and Selectin Inhibition
Ajit Varki,Jennifer L. Stevenson +1 more
TL;DR: In this article, in vitro and in vivo methods for identifying Heparins and Heparinoids that modulate the activity of selectins are presented. But the authors do not discuss how to identify and isolate these heparin formulations.
Journal ArticleDOI
Structural, immunological, and biosynthetic studies of a sialic acid-specific O-acetylesterase from rat liver.
C. Butor,H H Higa,Ajit Varki +2 more
TL;DR: Pulse-chase studies indicate that the two LSE subunits arise from a single precursor of approximately 65 kDa which yields a core polypeptide of apparent molecular mass approximately 53 kDa upon deglycosylation with peptide: N-glycosidase F, indicating N-linked oligosaccharide processing during passage through the Golgi.
Journal ArticleDOI
Chemo-enzymatic synthesis of the carbohydrate antigen N-glycolylneuraminic acid from glucose.
Oliver M. T. Pearce,Ajit Varki +1 more
TL;DR: The synthesis allows access to gram-scale quantities quickly and economically and produces Neu5Gc in superior quality to commercial sources and can be incorporated into the cell glycocalyx of human cells, which do not naturally synthesize this sugar.
Journal ArticleDOI
Unusual Anionic N-Linked Oligosaccharides from Bovine Lung
Karin E. Norgard-Sumnicht,Linda Roux,Derek Toomre,Adriana E. Manzi,Hudson H. Freeze,Ajit Varki +5 more
TL;DR: This library of N-linked oligosaccharides from an intact mammalian organ (lung) contains a high proportion of novel anionic sugar chains whose structures are different from conventional complex-type sialylated chains and only partially related to those from CPAE cells.