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Ajit Varki
Researcher at University of California, San Diego
Publications - 557
Citations - 63836
Ajit Varki is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Sialic acid & SIGLEC. The author has an hindex of 124, co-authored 542 publications receiving 58772 citations. Previous affiliations of Ajit Varki include Emory University & National Institute of Advanced Industrial Science and Technology.
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Journal ArticleDOI
How to make an ape brain.
TL;DR: Emergence of the ape brain was apparently facilitated by a retrotransposed gene duplicate that acquired brain-specific expression and functions affecting the neurotransmitter glutamate.
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9-O-Acetylation of Exogenously Added Ganglioside GD3 THE GD3 MOLECULE INDUCES ITS OWN O-ACETYLATION MACHINERY
TL;DR: To the authors' knowledge, this is the first example wherein a newly expressed or exogenously introduced ganglioside induces de novo synthesis of an enzymatic machinery to modify itself, and the first evidence for a mechanism of induction of sialic acid O-acetylation.
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Biosynthesis of oligosaccharides in intact Golgi preparations from rat liver. Analysis of N-linked glycans labeled by UDP-[6-3H]N-acetylglucosamine.
TL;DR: In this paper, structural characterization of the radiolabeled N-linked oligosaccharides shows a variety of distinct neutral and anionic species, including bi-, tri-, and tetra-antennary molecules with terminal beta-[3H] GlcNAc residues.
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Expression of Siglec-11 by human and chimpanzee ovarian stromal cells, with uniquely human ligands: implications for human ovarian physiology and pathology.
Xiaoxia Wang,Renee Chow,Liwen Deng,Daniel C. Anderson,Noel Weidner,Andrew K. Godwin,Chandra Bewtra,Albert Zlotnik,Jack D. Bui,Ajit Varki,Nissi Varki +10 more
TL;DR: Interestingly, there was a trend of increased Siglec-11 expression in post- menopausal ovaries compared with pre-menopausal ones, indicating potential roles for SigleC-11 in ovarian physiology and human evolution.
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Siglec-14 Enhances NLRP3-Inflammasome Activation in Macrophages.
Chih-Ming Tsai,Angelica M. Riestra,Syed Raza Ali,Jerry J. Fong,Janet Z. Liu,Gillian Hughes,Ajit Varki,Victor Nizet +7 more
TL;DR: The results identify a new immunoregulatory role of Siglec-14 as a positive regulator of NLRP3 inflammasome activation and increased IL-1β expression in primary macrophages from SIGLEC14+/+ individuals compared to those with the SIGleC14–/+ and SIGlec14–/– genotypes.