A
Ajit Varki
Researcher at University of California, San Diego
Publications - 557
Citations - 63836
Ajit Varki is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Sialic acid & SIGLEC. The author has an hindex of 124, co-authored 542 publications receiving 58772 citations. Previous affiliations of Ajit Varki include Emory University & National Institute of Advanced Industrial Science and Technology.
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Journal ArticleDOI
Group B streptococcal capsular sialic acids interact with siglecs (immunoglobulin-like lectins) on human leukocytes.
TL;DR: Production of Sia-capped bacterial polysaccharide capsules that mimic human cell surface glycans in order to engage CD33rSiglecs may be an example of a previously unrecognized bacterial mechanism of leukocyte manipulation.
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Involvement of a non-human sialic acid in human cancer
TL;DR: Experimental evidence in a human-like Neu5Gc-deficient Cmah−/−mouse model shows that inflammation due to “xenosialitis” caused by this antigen–antibody interaction can promote tumor progression, suggesting a likely mechanism for the well-known epidemiological link between red meat consumption and carcinoma risk.
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New Aspects of Siglec Binding Specificities, Including the Significance of Fucosylation and of the Sialyl-Tn Epitope
TL;DR: Several new aspects of specificities of the first six reported siglecs are explored, using sialylated glycans presented in multivalent form, on synthetic polyacrylamide backbones, or on mucin polypeptides.
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Alu-mediated inactivation of the human CMP- N-acetylneuraminic acid hydroxylase gene.
TL;DR: It is suggested that Alu elements have played potentially important roles in genotypic and phenotypic evolution in the hominid lineage.
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DNA aptamers block L-selectin function in vivo. Inhibition of human lymphocyte trafficking in SCID mice.
Brian Hicke,S R Watson,Andrea Koenig,C K Lynott,R F Bargatze,Y F Chang,S Ringquist,L Moon-McDermott,Susan Jennings,Tim Fitzwater,H L Han,Nissi Varki,I Albinana,M C Willis,Ajit Varki,David Parma +15 more
TL;DR: Using SELEX (Systematic Evolution of Ligands by EXponential Enrichment) technology, aptamers specific for L-selectin are generated that require divalent cations for binding and have low nanomolar affinity, indicating their potential utility as therapeutics.